5XK8

Crystal structure of Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 in complex with GPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002094	molecular_function	polyprenyltransferase activity
A	0005886	cellular_component	plasma membrane
A	0009409	biological_process	response to cold
A	0009668	biological_process	plastid membrane organization
A	0016094	biological_process	polyprenol biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
A	0045547	molecular_function	dehydrodolichyl diphosphate synthase activity
A	0046872	molecular_function	metal ion binding
B	0002094	molecular_function	polyprenyltransferase activity
B	0005886	cellular_component	plasma membrane
B	0009409	biological_process	response to cold
B	0009668	biological_process	plastid membrane organization
B	0016094	biological_process	polyprenol biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
B	0045547	molecular_function	dehydrodolichyl diphosphate synthase activity
B	0046872	molecular_function	metal ion binding
C	0002094	molecular_function	polyprenyltransferase activity
C	0005886	cellular_component	plasma membrane
C	0009409	biological_process	response to cold
C	0009668	biological_process	plastid membrane organization
C	0016094	biological_process	polyprenol biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
C	0045547	molecular_function	dehydrodolichyl diphosphate synthase activity
C	0046872	molecular_function	metal ion binding
D	0002094	molecular_function	polyprenyltransferase activity
D	0005886	cellular_component	plasma membrane
D	0009409	biological_process	response to cold
D	0009668	biological_process	plastid membrane organization
D	0016094	biological_process	polyprenol biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
D	0045547	molecular_function	dehydrodolichyl diphosphate synthase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue GPP A 501

Chain	Residue
A	PRO8
A	TYR58
A	ARG60
A	ALA68
A	HOH602
A	HOH619
A	HOH676
A	ASP9
A	GLY10
A	MET11
A	ARG12
A	ARG13
A	TYR26
A	VAL52
A	ASN57

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG B 500

Chain	Residue
B	ASP9
B	GPP501
B	HOH601
B	HOH696

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site_id	AC3
Number of Residues	14
Details	binding site for residue GPP B 501

Chain	Residue
A	TYR215
B	PRO8
B	ASP9
B	GLY10
B	MET11
B	ARG12
B	ARG13
B	TYR26
B	VAL52
B	ASN57
B	ARG60
B	ALA68
B	MG500
B	HOH601

---

site_id	AC4
Number of Residues	12
Details	binding site for residue GPP C 501

Chain	Residue
C	PRO8
C	ASP9
C	GLY10
C	MET11
C	ARG12
C	ARG13
C	TYR26
C	ASN57
C	ARG60
C	ALA68
C	HOH601
C	HOH610

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site_id	AC5
Number of Residues	9
Details	binding site for residue GPP D 501

Chain	Residue
D	PRO8
D	ASP9
D	GLY10
D	MET11
D	ARG12
D	ARG13
D	TYR26
D	ARG60
D	ALA68

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