5XK7
Crystal structure of Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 in complex with DMAPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002094 | molecular_function | polyprenyltransferase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009409 | biological_process | response to cold |
| A | 0009668 | biological_process | plastid membrane organization |
| A | 0016094 | biological_process | polyprenol biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0033850 | molecular_function | Z-farnesyl diphosphate synthase activity |
| A | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0002094 | molecular_function | polyprenyltransferase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009409 | biological_process | response to cold |
| B | 0009668 | biological_process | plastid membrane organization |
| B | 0016094 | biological_process | polyprenol biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0033850 | molecular_function | Z-farnesyl diphosphate synthase activity |
| B | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0002094 | molecular_function | polyprenyltransferase activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009409 | biological_process | response to cold |
| C | 0009668 | biological_process | plastid membrane organization |
| C | 0016094 | biological_process | polyprenol biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0033850 | molecular_function | Z-farnesyl diphosphate synthase activity |
| C | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0002094 | molecular_function | polyprenyltransferase activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0009409 | biological_process | response to cold |
| D | 0009668 | biological_process | plastid membrane organization |
| D | 0016094 | biological_process | polyprenol biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| D | 0033850 | molecular_function | Z-farnesyl diphosphate synthase activity |
| D | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | ASP9 |
| A | POP302 |
| A | POP303 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue POP A 302 |
| Chain | Residue |
| A | ARG60 |
| A | MG301 |
| A | POP303 |
| A | HOH512 |
| A | ASP9 |
| A | GLY10 |
| A | MET11 |
| A | ARG12 |
| A | ARG13 |
| A | TYR26 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue POP A 303 |
| Chain | Residue |
| A | ASP9 |
| A | SER54 |
| A | ASN57 |
| A | ARG60 |
| A | ARG163 |
| A | ARG169 |
| A | SER171 |
| A | PHE173 |
| A | MG301 |
| A | POP302 |
| A | HOH404 |
| A | HOH405 |
| A | HOH413 |
| A | HOH448 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue MES A 304 |
| Chain | Residue |
| A | TYR184 |
| A | PHE185 |
| A | ASP204 |
| A | ARG208 |
| A | HOH436 |
| A | HOH484 |
| A | HOH530 |
| B | VAL168 |
| B | HOH458 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | ARG211 |
| A | HOH406 |
| A | HOH491 |
| B | ARG13 |
| B | HIS167 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 301 |
| Chain | Residue |
| B | ASP9 |
| B | POP302 |
| B | DMA303 |
| B | HOH411 |
| B | HOH489 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | binding site for residue POP B 302 |
| Chain | Residue |
| A | TYR215 |
| B | ASP9 |
| B | GLY10 |
| B | MET11 |
| B | ARG12 |
| B | ARG13 |
| B | TYR26 |
| B | ARG60 |
| B | MG301 |
| B | DMA303 |
| B | HOH411 |
| B | HOH429 |
| B | HOH489 |
| site_id | AC8 |
| Number of Residues | 23 |
| Details | binding site for residue DMA B 303 |
| Chain | Residue |
| A | PHE180 |
| A | ARG211 |
| A | TYR212 |
| A | GLY213 |
| B | LEU7 |
| B | PRO8 |
| B | ASP9 |
| B | THR51 |
| B | VAL52 |
| B | ASN57 |
| B | ARG60 |
| B | ARG163 |
| B | ARG169 |
| B | SER171 |
| B | PHE173 |
| B | MG301 |
| B | POP302 |
| B | HOH411 |
| B | HOH427 |
| B | HOH429 |
| B | HOH445 |
| B | HOH454 |
| B | HOH489 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue MES B 304 |
| Chain | Residue |
| A | VAL168 |
| B | TYR184 |
| B | PHE185 |
| B | CYS186 |
| B | PRO187 |
| B | ARG208 |
| B | HOH458 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 301 |
| Chain | Residue |
| C | ASP9 |
| C | POP302 |
| C | DMA303 |
| C | HOH513 |
| C | HOH528 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue POP C 302 |
| Chain | Residue |
| C | TYR26 |
| C | ARG60 |
| C | MG301 |
| C | DMA303 |
| C | HOH470 |
| C | HOH513 |
| C | HOH528 |
| C | ASP9 |
| C | GLY10 |
| C | MET11 |
| C | ARG12 |
| C | ARG13 |
| site_id | AD3 |
| Number of Residues | 14 |
| Details | binding site for residue DMA C 303 |
| Chain | Residue |
| C | LEU7 |
| C | PRO8 |
| C | THR51 |
| C | VAL52 |
| C | ASN57 |
| C | ARG163 |
| C | ARG169 |
| C | SER171 |
| C | PHE173 |
| C | MG301 |
| C | POP302 |
| C | HOH407 |
| C | HOH459 |
| C | HOH528 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue MES C 304 |
| Chain | Residue |
| C | TYR184 |
| C | PHE185 |
| C | CYS186 |
| C | ARG208 |
| D | HOH536 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 C 305 |
| Chain | Residue |
| C | ARG211 |
| C | HOH403 |
| C | HOH411 |
| C | HOH523 |
| D | ARG13 |
| D | HIS167 |
| D | HOH490 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 301 |
| Chain | Residue |
| D | ASP9 |
| D | POP302 |
| D | DMA303 |
| D | HOH405 |
| D | HOH432 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for residue POP D 302 |
| Chain | Residue |
| C | ARG211 |
| C | TYR215 |
| D | ASP9 |
| D | GLY10 |
| D | MET11 |
| D | ARG12 |
| D | ARG13 |
| D | TYR26 |
| D | ARG60 |
| D | MG301 |
| D | DMA303 |
| D | HOH405 |
| D | HOH432 |
| D | HOH471 |
| site_id | AD8 |
| Number of Residues | 23 |
| Details | binding site for residue DMA D 303 |
| Chain | Residue |
| C | PHE180 |
| C | ARG211 |
| C | TYR212 |
| C | GLY213 |
| C | HOH442 |
| D | LEU7 |
| D | PRO8 |
| D | ASP9 |
| D | THR51 |
| D | VAL52 |
| D | ASN57 |
| D | ARG60 |
| D | ARG163 |
| D | ARG169 |
| D | SER171 |
| D | PHE173 |
| D | MG301 |
| D | POP302 |
| D | HOH405 |
| D | HOH422 |
| D | HOH423 |
| D | HOH432 |
| D | HOH471 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue MES D 304 |
| Chain | Residue |
| C | VAL168 |
| D | TYR184 |
| D | PHE185 |
| D | PRO187 |
| D | ARG208 |
| D | HOH446 |
| D | HOH536 |
