5XIX
The canonical domain of human asparaginyl-tRNA synthetase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004816 | molecular_function | asparagine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006421 | biological_process | asparaginyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004816 | molecular_function | asparagine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006421 | biological_process | asparaginyl-tRNA aminoacylation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004816 | molecular_function | asparagine-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006421 | biological_process | asparaginyl-tRNA aminoacylation |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004816 | molecular_function | asparagine-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006421 | biological_process | asparaginyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 601 |
| Chain | Residue |
| A | GOL605 |
| A | HOH837 |
| A | HOH895 |
| D | ASN169 |
| D | LEU172 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | ASP258 |
| A | SER368 |
| A | HOH756 |
| A | HOH870 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | GLN319 |
| A | GLU334 |
| A | TYR335 |
| A | THR336 |
| A | GLU521 |
| A | CYS537 |
| A | LEU538 |
| A | HOH710 |
| A | HOH715 |
| A | HOH772 |
| D | THR269 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | PHE344 |
| A | THR346 |
| D | PHE131 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | TYR168 |
| A | ASN169 |
| A | LEU172 |
| A | GOL601 |
| A | HOH726 |
| D | HOH875 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 606 |
| Chain | Residue |
| A | PHE261 |
| A | TYR265 |
| A | TYR266 |
| A | HOH869 |
| D | ARG254 |
| D | HOH784 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 607 |
| Chain | Residue |
| A | GLN301 |
| A | HIS337 |
| A | GLU339 |
| A | TYR516 |
| A | GLY517 |
| A | HOH713 |
| A | HOH805 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | binding site for residue GOL B 601 |
| Chain | Residue |
| B | ARG249 |
| B | GLN319 |
| B | GLU334 |
| B | TYR335 |
| B | THR336 |
| B | GLU521 |
| B | CYS537 |
| B | LEU538 |
| B | HOH717 |
| B | HOH722 |
| B | HOH753 |
| C | THR269 |
| C | HOH721 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 602 |
| Chain | Residue |
| B | MET251 |
| B | ASP258 |
| B | SER368 |
| B | HOH819 |
| B | HOH822 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| B | TYR168 |
| B | ASN169 |
| B | LEU172 |
| C | GOL601 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | ASP288 |
| B | PHE290 |
| C | LEU284 |
| C | PHE285 |
| C | LYS286 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | PHE261 |
| B | TYR265 |
| B | TYR266 |
| B | HOH831 |
| C | ARG254 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 606 |
| Chain | Residue |
| B | ASP455 |
| B | SER456 |
| B | ARG457 |
| B | HOH845 |
| D | HIS403 |
| D | VAL405 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 607 |
| Chain | Residue |
| B | HIS337 |
| B | GLU339 |
| B | GLY517 |
| B | LEU518 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 601 |
| Chain | Residue |
| B | GOL603 |
| C | ASN169 |
| site_id | AD7 |
| Number of Residues | 12 |
| Details | binding site for residue GOL C 602 |
| Chain | Residue |
| B | THR269 |
| C | ARG249 |
| C | GLN319 |
| C | TYR335 |
| C | THR336 |
| C | GLU521 |
| C | CYS537 |
| C | LEU538 |
| C | TYR539 |
| C | HOH728 |
| C | HOH757 |
| C | HOH843 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 603 |
| Chain | Residue |
| B | ALA211 |
| B | PRO212 |
| B | ALA213 |
| C | LEU172 |
| C | ALA211 |
| C | ALA213 |
| B | LEU172 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 604 |
| Chain | Residue |
| C | GLU454 |
| C | ASP455 |
| C | SER456 |
| C | ARG457 |
| C | HOH711 |
| D | PHE415 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 605 |
| Chain | Residue |
| B | TYR266 |
| C | MET251 |
| C | PRO369 |
| C | ALA370 |
| C | ILE373 |
| C | HOH755 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 606 |
| Chain | Residue |
| C | ARG425 |
| C | ASN468 |
| C | VAL469 |
| C | THR525 |
| C | TRP526 |
| C | ARG530 |
| C | TYR531 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 607 |
| Chain | Residue |
| C | ARG254 |
| C | ASP258 |
| C | SER368 |
| C | HOH772 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 608 |
| Chain | Residue |
| B | LYS116 |
| B | THR153 |
| C | GLY264 |
| C | TYR266 |
| C | LEU311 |
| C | GLY312 |
| C | ASP313 |
| C | HOH701 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 601 |
| Chain | Residue |
| D | MET251 |
| D | ASP258 |
| D | SER368 |
| D | HOH832 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 602 |
| Chain | Residue |
| C | PHE415 |
| D | GLU454 |
| D | ASP455 |
| D | SER456 |
| D | ARG457 |
| D | HOH704 |
| site_id | AE7 |
| Number of Residues | 11 |
| Details | binding site for residue GOL D 603 |
| Chain | Residue |
| A | THR269 |
| D | ARG249 |
| D | GLN319 |
| D | GLU334 |
| D | TYR335 |
| D | THR336 |
| D | GLU521 |
| D | CYS537 |
| D | LEU538 |
| D | HOH707 |
| D | HOH819 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 604 |
| Chain | Residue |
| A | LEU210 |
| A | HOH895 |
| D | TYR168 |
| D | ASP481 |
| D | SER482 |
| D | ARG506 |
| D | THR510 |
| D | HOH907 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 605 |
| Chain | Residue |
| A | LEU172 |
| A | ALA211 |
| A | PRO212 |
| A | ALA213 |
| D | LEU172 |
| D | ALA211 |
| D | PRO212 |
| D | ALA213 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8BP47","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8BP47","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
