5XIS
Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form I
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| C | LYS27-ASP52 | |
| B | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| C | ARG54 | |
| C | ARG72 | |
| F | ARG54 | |
| F | ARG72 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| C | HIS68 | |
| F | HIS68 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P62979 |
| Chain | Residue | Details |
| C | SER65 | |
| F | SER65 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000250|UniProtKB:P62979 |
| Chain | Residue | Details |
| C | GLY76 | |
| F | GLY76 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979 |
| Chain | Residue | Details |
| C | LYS6 | |
| F | LYS27 | |
| F | LYS29 | |
| F | LYS33 | |
| F | LYS48 | |
| F | ARG63 | |
| C | LYS11 | |
| C | LYS27 | |
| C | LYS29 | |
| C | LYS33 | |
| C | LYS48 | |
| C | ARG63 | |
| F | LYS6 | |
| F | LYS11 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 |
| Chain | Residue | Details |
| C | GLY76 | |
| F | GLY76 |
