5XF8

Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state

Replaces:  5H7I
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Functional Information from GO Data

ChainGOidnamespacecontents
C0005737cellular_componentcytoplasm
C0005656cellular_componentnuclear pre-replicative complex
C0005634cellular_componentnucleus
C0003688molecular_functionDNA replication origin binding
C0051301biological_processcell division
C0000727biological_processdouble-strand break repair via break-induced replication
C0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
C0030174biological_processregulation of DNA-dependent DNA replication initiation
20071162cellular_componentCMG complex
20005737cellular_componentcytoplasm
20031261cellular_componentDNA replication preinitiation complex
20042555cellular_componentMCM complex
20005656cellular_componentnuclear pre-replicative complex
20005654cellular_componentnucleoplasm
20005634cellular_componentnucleus
20031298cellular_componentreplication fork protection complex
20005524molecular_functionATP binding
20003682molecular_functionchromatin binding
20003688molecular_functionDNA replication origin binding
20004386molecular_functionhelicase activity
20046872molecular_functionmetal ion binding
20006974biological_processcellular response to DNA damage stimulus
20032508biological_processDNA duplex unwinding
20006271biological_processDNA strand elongation involved in DNA replication
20000727biological_processdouble-strand break repair via break-induced replication
21902975biological_processmitotic DNA replication initiation
21902450biological_processnegative regulation of ATP-dependent DNA helicase activity
20006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
30000781cellular_componentchromosome, telomeric region
30071162cellular_componentCMG complex
30005737cellular_componentcytoplasm
30031261cellular_componentDNA replication preinitiation complex
30042555cellular_componentMCM complex
30005656cellular_componentnuclear pre-replicative complex
30005654cellular_componentnucleoplasm
30005634cellular_componentnucleus
30031298cellular_componentreplication fork protection complex
30005524molecular_functionATP binding
30003682molecular_functionchromatin binding
30003688molecular_functionDNA replication origin binding
30004386molecular_functionhelicase activity
31904931molecular_functionMCM complex binding
30030466biological_processchromatin silencing at silent mating-type cassette
30006348biological_processchromatin silencing at telomere
30032508biological_processDNA duplex unwinding
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30000727biological_processdouble-strand break repair via break-induced replication
31902975biological_processmitotic DNA replication initiation
30006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
40071162cellular_componentCMG complex
40005737cellular_componentcytoplasm
40031261cellular_componentDNA replication preinitiation complex
40042555cellular_componentMCM complex
40097373cellular_componentMCM core complex
40005656cellular_componentnuclear pre-replicative complex
40043596cellular_componentnuclear replication fork
40005654cellular_componentnucleoplasm
40005634cellular_componentnucleus
40031298cellular_componentreplication fork protection complex
40005524molecular_functionATP binding
40003678molecular_functionDNA helicase activity
40003688molecular_functionDNA replication origin binding
40003697molecular_functionsingle-stranded DNA binding
40006270biological_processDNA replication initiation
40006271biological_processDNA strand elongation involved in DNA replication
40006268biological_processDNA unwinding involved in DNA replication
40000727biological_processdouble-strand break repair via break-induced replication
40033260biological_processnuclear DNA replication
40006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
50071162cellular_componentCMG complex
50005737cellular_componentcytoplasm
50031261cellular_componentDNA replication preinitiation complex
50042555cellular_componentMCM complex
50000784cellular_componentnuclear chromosome, telomeric region
50005656cellular_componentnuclear pre-replicative complex
50005654cellular_componentnucleoplasm
50005634cellular_componentnucleus
50031298cellular_componentreplication fork protection complex
50005524molecular_functionATP binding
50003682molecular_functionchromatin binding
50003688molecular_functionDNA replication origin binding
50004386molecular_functionhelicase activity
50006348biological_processchromatin silencing at telomere
50032508biological_processDNA duplex unwinding
50006270biological_processDNA replication initiation
50000727biological_processdouble-strand break repair via break-induced replication
50006343biological_processestablishment of chromatin silencing
50031939biological_processnegative regulation of chromatin silencing at telomere
50033260biological_processnuclear DNA replication
50006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
50030174biological_processregulation of DNA-dependent DNA replication initiation
60071162cellular_componentCMG complex
60005737cellular_componentcytoplasm
60031261cellular_componentDNA replication preinitiation complex
60042555cellular_componentMCM complex
60097373cellular_componentMCM core complex
60005656cellular_componentnuclear pre-replicative complex
60005654cellular_componentnucleoplasm
60005634cellular_componentnucleus
60031298cellular_componentreplication fork protection complex
60005524molecular_functionATP binding
60003678molecular_functionDNA helicase activity
60003688molecular_functionDNA replication origin binding
60043142molecular_functionsingle-stranded DNA-dependent ATPase activity
60006270biological_processDNA replication initiation
60006271biological_processDNA strand elongation involved in DNA replication
60006268biological_processDNA unwinding involved in DNA replication
60000727biological_processdouble-strand break repair via break-induced replication
60006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
70000781cellular_componentchromosome, telomeric region
70071162cellular_componentCMG complex
70005737cellular_componentcytoplasm
70031261cellular_componentDNA replication preinitiation complex
70042555cellular_componentMCM complex
70097373cellular_componentMCM core complex
70005656cellular_componentnuclear pre-replicative complex
70005654cellular_componentnucleoplasm
70005634cellular_componentnucleus
70031298cellular_componentreplication fork protection complex
70005524molecular_functionATP binding
70003682molecular_functionchromatin binding
70003678molecular_functionDNA helicase activity
70003688molecular_functionDNA replication origin binding
71904931molecular_functionMCM complex binding
70043142molecular_functionsingle-stranded DNA-dependent ATPase activity
70030466biological_processchromatin silencing at silent mating-type cassette
70006348biological_processchromatin silencing at telomere
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006268biological_processDNA unwinding involved in DNA replication
70000727biological_processdouble-strand break repair via break-induced replication
70033260biological_processnuclear DNA replication
70006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI18ATP. {ECO:0000255}.
ChainResidueDetails
2GLY543-SER550

SWS_FT_FI28ATP. {ECO:0000255}.
ChainResidueDetails
3GLY435-SER442

SWS_FT_FI38ATP. {ECO:0000255}.
ChainResidueDetails
4GLY568-SER575

SWS_FT_FI48ATP. {ECO:0000255}.
ChainResidueDetails
5GLY416-SER423

SWS_FT_FI58ATP. {ECO:0000255}.
ChainResidueDetails
6GLY575-SER582

SWS_FT_FI68ATP. {ECO:0000255}.
ChainResidueDetails
7GLY460-SER467

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Catalytic Information from CSA

site_idNumber of ResiduesDetails