Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006260 | biological_process | DNA replication |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| A | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0006260 | biological_process | DNA replication |
| B | 0006281 | biological_process | DNA repair |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| B | 0044716 | molecular_function | 8-oxo-GDP phosphatase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue ATP B 401 |
| Chain | Residue |
| B | ARG55 |
| B | ASP148 |
| B | PO4402 |
| B | MG407 |
| B | MG410 |
| B | F411 |
| B | F413 |
| B | HOH578 |
| B | HOH588 |
| B | HOH595 |
| B | HOH612 |
| B | ARG57 |
| B | HOH615 |
| B | HOH626 |
| B | HOH629 |
| B | HOH696 |
| B | HOH699 |
| B | TYR58 |
| B | LYS65 |
| B | LYS67 |
| B | TYR101 |
| B | LYS108 |
| B | GLU127 |
| B | TYR145 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| B | ARG57 |
| B | LYS67 |
| B | HIS249 |
| B | LYS250 |
| B | ARG253 |
| B | ATP401 |
| B | MG410 |
| B | F411 |
| B | F412 |
| B | F413 |
| B | HOH531 |
| B | HOH575 |
| B | HOH653 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | ARG95 |
| B | TRP111 |
| B | LEU316 |
| B | HOH542 |
| B | HOH631 |
| B | HOH687 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | ARG184 |
| B | ASP215 |
| B | ARG216 |
| B | VAL217 |
| B | HIS220 |
| B | HOH507 |
| B | HOH754 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| B | ARG25 |
| B | LEU68 |
| B | ASP69 |
| B | GLN70 |
| B | GLY71 |
| B | GLU72 |
| B | HOH682 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| B | ILE275 |
| B | PRO276 |
| B | GLU280 |
| B | GLY294 |
| B | ASN295 |
| B | TRP301 |
| B | HOH559 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue MG B 407 |
| Chain | Residue |
| B | LYS65 |
| B | GLU85 |
| B | GLU127 |
| B | ATP401 |
| B | MG408 |
| B | MG410 |
| B | F411 |
| B | HOH588 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue MG B 408 |
| Chain | Residue |
| B | GLU81 |
| B | GLU85 |
| B | GLU127 |
| B | MG407 |
| B | MG409 |
| B | MG410 |
| B | F411 |
| B | F412 |
| B | HOH613 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue MG B 409 |
| Chain | Residue |
| B | GLU81 |
| B | MG408 |
| B | MG410 |
| B | F412 |
| B | F413 |
| B | HOH531 |
| B | HOH571 |
| B | HOH606 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue MG B 410 |
| Chain | Residue |
| B | LYS67 |
| B | GLU127 |
| B | ATP401 |
| B | PO4402 |
| B | MG407 |
| B | MG408 |
| B | MG409 |
| B | F411 |
| B | F412 |
| B | F413 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for residue F B 411 |
| Chain | Residue |
| B | LYS65 |
| B | GLY66 |
| B | GLU81 |
| B | GLU85 |
| B | GLU127 |
| B | ATP401 |
| B | PO4402 |
| B | MG407 |
| B | MG408 |
| B | MG410 |
| B | F412 |
| B | F413 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue F B 412 |
| Chain | Residue |
| B | GLU81 |
| B | GLU127 |
| B | LYS250 |
| B | PO4402 |
| B | MG408 |
| B | MG409 |
| B | MG410 |
| B | F411 |
| B | F413 |
| B | HOH531 |
| B | HOH571 |
| B | HOH613 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for residue F B 413 |
| Chain | Residue |
| B | GLY66 |
| B | LYS67 |
| B | GLU81 |
| B | ATP401 |
| B | PO4402 |
| B | MG409 |
| B | MG410 |
| B | F411 |
| B | F412 |
| B | HOH531 |
| B | HOH606 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 414 |
| Chain | Residue |
| B | HIS170 |
| B | ARG186 |
| B | HOH665 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 415 |
| Chain | Residue |
| B | TRP282 |
| B | LEU310 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 416 |
| Chain | Residue |
| B | ARG296 |
| B | LYS297 |
| B | HOH749 |
| site_id | AD8 |
| Number of Residues | 18 |
| Details | binding site for residue ATP A 401 |
| Chain | Residue |
| A | ARG55 |
| A | TYR58 |
| A | LYS65 |
| A | LYS67 |
| A | TYR101 |
| A | LYS108 |
| A | GLU127 |
| A | TYR145 |
| A | MG405 |
| A | MG408 |
| A | F409 |
| A | F411 |
| A | HOH509 |
| A | HOH557 |
| A | HOH564 |
| A | HOH591 |
| A | HOH601 |
| A | HOH603 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | ARG95 |
| A | TRP111 |
| A | TYR315 |
| A | LEU316 |
| A | SER317 |
| A | HOH562 |
| A | HOH588 |
| A | HOH598 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ASP215 |
| A | ARG216 |
| A | HIS220 |
| A | HOH592 |
| site_id | AE2 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 404 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue MG A 405 |
| Chain | Residue |
| A | LYS65 |
| A | GLU85 |
| A | GLU127 |
| A | ATP401 |
| A | MG406 |
| A | MG408 |
| A | F409 |
| A | HOH564 |
| site_id | AE4 |
| Number of Residues | 9 |
| Details | binding site for residue MG A 406 |
| Chain | Residue |
| A | GLU81 |
| A | GLU85 |
| A | GLU127 |
| A | MG405 |
| A | MG407 |
| A | MG408 |
| A | F409 |
| A | F410 |
| A | HOH531 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 407 |
| Chain | Residue |
| A | GLU81 |
| A | MG406 |
| A | MG408 |
| A | F410 |
| A | F411 |
| A | HOH515 |
| A | HOH549 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue MG A 408 |
| Chain | Residue |
| A | LYS67 |
| A | ATP401 |
| A | MG405 |
| A | MG406 |
| A | MG407 |
| A | F409 |
| A | F410 |
| A | F411 |
| site_id | AE7 |
| Number of Residues | 11 |
| Details | binding site for residue F A 409 |
| Chain | Residue |
| A | LYS65 |
| A | GLY66 |
| A | GLU81 |
| A | GLU85 |
| A | GLU127 |
| A | ATP401 |
| A | MG405 |
| A | MG406 |
| A | MG408 |
| A | F410 |
| A | F411 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue F A 410 |
| Chain | Residue |
| A | GLU81 |
| A | GLU127 |
| A | MG406 |
| A | MG407 |
| A | MG408 |
| A | F409 |
| A | F411 |
| A | HOH515 |
| A | HOH531 |
| site_id | AE9 |
| Number of Residues | 9 |
| Details | binding site for residue F A 411 |
| Chain | Residue |
| A | GLY66 |
| A | LYS67 |
| A | GLU81 |
| A | ATP401 |
| A | MG407 |
| A | MG408 |
| A | F409 |
| A | F410 |
| A | HOH549 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 412 |
| Chain | Residue |
| A | HIS170 |
| A | ARG186 |
| A | HOH565 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 413 |
| Chain | Residue |
| A | ARG216 |
| A | GLU242 |
| A | GLU243 |
| A | GLN271 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 414 |
| Chain | Residue |
| A | ARG184 |
| A | ARG216 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 415 |
| Chain | Residue |
| A | ARG296 |
| A | LYS297 |
| A | HOH648 |
| A | HOH657 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GkldqgEtepvAAaREIhEEtG |
| Chain | Residue | Details |
| B | GLY66-GLY87 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Motif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28375146","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28705712","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28375146","evidenceCode":"ECO:0000269"}]} |
