5XAT
Structural insights into the elevator-like mechanism of the sodium/citrate symporter CitS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006101 | biological_process | citrate metabolic process |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0008514 | molecular_function | organic anion transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015711 | biological_process | organic anion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006101 | biological_process | citrate metabolic process |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0008514 | molecular_function | organic anion transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015711 | biological_process | organic anion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006101 | biological_process | citrate metabolic process |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0008514 | molecular_function | organic anion transmembrane transporter activity |
| C | 0015293 | molecular_function | symporter activity |
| C | 0015711 | biological_process | organic anion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006101 | biological_process | citrate metabolic process |
| D | 0006814 | biological_process | sodium ion transport |
| D | 0008514 | molecular_function | organic anion transmembrane transporter activity |
| D | 0015293 | molecular_function | symporter activity |
| D | 0015711 | biological_process | organic anion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 64 |
| Details | TRANSMEM: Helical; Name=TM 1 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | LEU28-TYR44 | |
| B | LEU28-TYR44 | |
| C | LEU28-TYR44 | |
| D | LEU28-TYR44 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 168 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | ASN45-ASP50 | |
| C | ALA96-ASN115 | |
| C | LYS288-HIS299 | |
| C | GLN352-THR359 | |
| D | ASN45-ASP50 | |
| D | ALA96-ASN115 | |
| D | LYS288-HIS299 | |
| D | GLN352-THR359 | |
| A | ALA96-ASN115 | |
| A | LYS288-HIS299 | |
| A | GLN352-THR359 | |
| B | ASN45-ASP50 | |
| B | ALA96-ASN115 | |
| B | LYS288-HIS299 | |
| B | GLN352-THR359 | |
| C | ASN45-ASP50 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=TM 2 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | ILE51-ARG71 | |
| B | ILE51-ARG71 | |
| C | ILE51-ARG71 | |
| D | ILE51-ARG71 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 96 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | LEU72-GLY80 | |
| D | LEU72-GLY80 | |
| D | SER131-LEU136 | |
| D | LEU316-ARG327 | |
| A | SER131-LEU136 | |
| A | LEU316-ARG327 | |
| B | LEU72-GLY80 | |
| B | SER131-LEU136 | |
| B | LEU316-ARG327 | |
| C | LEU72-GLY80 | |
| C | SER131-LEU136 | |
| C | LEU316-ARG327 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=TM 3 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | GLY81-TYR95 | |
| B | GLY81-TYR95 | |
| C | GLY81-TYR95 | |
| D | GLY81-TYR95 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=TM 4 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | PHE116-LEU130 | |
| B | PHE116-LEU130 | |
| C | PHE116-LEU130 | |
| D | PHE116-LEU130 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 116 |
| Details | TRANSMEM: Helical; Name=TM 5 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | LEU137-PHE166 | |
| B | LEU137-PHE166 | |
| C | LEU137-PHE166 | |
| D | LEU137-PHE166 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 144 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:10825453, ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | GLY167-ILE181 | |
| A | ALA190-ALA212 | |
| B | GLY167-ILE181 | |
| B | ALA190-ALA212 | |
| C | GLY167-ILE181 | |
| C | ALA190-ALA212 | |
| D | GLY167-ILE181 | |
| D | ALA190-ALA212 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 28 |
| Details | INTRAMEM: Helical; Name=TM 6 (HP1) => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | MET182-GLY189 | |
| B | MET182-GLY189 | |
| C | MET182-GLY189 | |
| D | MET182-GLY189 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=TM 7 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | ILE213-ILE233 | |
| B | ILE213-ILE233 | |
| C | ILE213-ILE233 | |
| D | ILE213-ILE233 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 220 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10825453, ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | GLY234-THR264 | |
| D | GLY234-THR264 | |
| D | TRP382-CYS398 | |
| D | ASP407-ARG416 | |
| A | TRP382-CYS398 | |
| A | ASP407-ARG416 | |
| B | GLY234-THR264 | |
| B | TRP382-CYS398 | |
| B | ASP407-ARG416 | |
| C | GLY234-THR264 | |
| C | TRP382-CYS398 | |
| C | ASP407-ARG416 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 88 |
| Details | TRANSMEM: Helical; Name=TM 8 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | HIS265-LYS287 | |
| B | HIS265-LYS287 | |
| C | HIS265-LYS287 | |
| D | HIS265-LYS287 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical; Name=TM 9 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | TYR300-GLY315 | |
| B | TYR300-GLY315 | |
| C | TYR300-GLY315 | |
| D | TYR300-GLY315 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 92 |
| Details | TRANSMEM: Helical; Name=TM 10 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | LEU328-LEU351 | |
| B | LEU328-LEU351 | |
| C | LEU328-LEU351 | |
| D | LEU328-LEU351 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Name=TM 11 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | PHE360-GLY381 | |
| B | PHE360-GLY381 | |
| C | PHE360-GLY381 | |
| D | PHE360-GLY381 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 28 |
| Details | INTRAMEM: Helical; Name=TM 12 (HP2) => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | MET399-GLY406 | |
| B | MET399-GLY406 | |
| C | MET399-GLY406 | |
| D | MET399-GLY406 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 84 |
| Details | TRANSMEM: Helical; Name=TM 13 => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | MET417-ALA438 | |
| B | MET417-ALA438 | |
| C | MET417-ALA438 | |
| D | MET417-ALA438 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 28 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:28566738, ECO:0000269|PubMed:8810332, ECO:0007744|PDB:5XAS |
| Chain | Residue | Details |
| A | SER439-ILE446 | |
| B | SER439-ILE446 | |
| C | SER439-ILE446 | |
| D | SER439-ILE446 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5XAR, ECO:0007744|PDB:5XAS, ECO:0007744|PDB:5XAT |
| Chain | Residue | Details |
| A | ILE181 | |
| C | GLY183 | |
| C | MET399 | |
| C | ASN401 | |
| D | ILE181 | |
| D | GLY183 | |
| D | MET399 | |
| D | ASN401 | |
| A | GLY183 | |
| A | MET399 | |
| A | ASN401 | |
| B | ILE181 | |
| B | GLY183 | |
| B | MET399 | |
| B | ASN401 | |
| C | ILE181 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28566738, ECO:0007744|PDB:5X9R, ECO:0007744|PDB:5XAS, ECO:0007744|PDB:5XAT |
| Chain | Residue | Details |
| A | ASN186 | |
| B | GLY404 | |
| B | SER405 | |
| B | ARG428 | |
| C | ASN186 | |
| C | GLY187 | |
| C | ARG402 | |
| C | GLY404 | |
| C | SER405 | |
| C | ARG428 | |
| D | ASN186 | |
| A | GLY187 | |
| D | GLY187 | |
| D | ARG402 | |
| D | GLY404 | |
| D | SER405 | |
| D | ARG428 | |
| A | ARG402 | |
| A | GLY404 | |
| A | SER405 | |
| A | ARG428 | |
| B | ASN186 | |
| B | GLY187 | |
| B | ARG402 |
