5X9G

Crystal structure of the cytosolic domain of the Mg2+ channel MgtE in complex with ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0015693	biological_process	magnesium ion transport
A	0016020	cellular_component	membrane
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0015693	biological_process	magnesium ion transport
B	0016020	cellular_component	membrane
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0015693	biological_process	magnesium ion transport
C	0016020	cellular_component	membrane
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0015693	biological_process	magnesium ion transport
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ATP A 301

Chain	Residue
A	TYR170
A	PRO231
D	GLU166
D	TYR169
A	VAL183
A	SER185
A	ARG187
A	ASP188
A	ASN203
A	LYS205
A	VAL207
A	PHE227

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 302

Chain	Residue
A	ASP91
A	GLU166
A	THR244
A	ASP247

---

site_id	AC3
Number of Residues	2
Details	binding site for residue MG A 303

Chain	Residue
A	ASP95
A	GLY136

---

site_id	AC4
Number of Residues	13
Details	binding site for residue ATP B 301

Chain	Residue
B	TYR170
B	VAL183
B	SER185
B	ARG187
B	ASP188
B	ASN203
B	LYS205
B	VAL206
B	VAL207
B	PHE227
B	PRO231
C	GLU166
C	TYR169

---

site_id	AC5
Number of Residues	2
Details	binding site for residue MG B 302

Chain	Residue
B	ASP95
B	GLY136

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG B 303

Chain	Residue
B	ASP91
B	GLU166
B	ASP247

---

site_id	AC7
Number of Residues	11
Details	binding site for residue ATP C 301

Chain	Residue
B	GLU166
B	TYR169
C	TYR170
C	VAL183
C	SER185
C	ARG187
C	ASP188
C	ASN203
C	VAL207
C	PHE227
C	PRO231

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG C 302

Chain	Residue
C	ASP91
C	GLU166
C	THR244
C	ASP247

---

site_id	AC9
Number of Residues	2
Details	binding site for residue MG C 303

Chain	Residue
C	ASP95
C	GLY136

---

site_id	AD1
Number of Residues	11
Details	binding site for residue ATP D 301

Chain	Residue
A	GLU166
D	TYR170
D	VAL183
D	SER185
D	ARG187
D	ASP188
D	ASN203
D	VAL206
D	VAL207
D	PHE227
D	PRO231

---

site_id	AD2
Number of Residues	4
Details	binding site for residue MG D 302

Chain	Residue
D	ASP91
D	GLU166
D	THR244
D	ASP247

---

site_id	AD3
Number of Residues	2
Details	binding site for residue MG D 303

Chain	Residue
D	ASP95
D	GLY136

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:19798051, ECO:0000269|PubMed:28747715

Chain	Residue	Details
A	GLU59
C	GLU216
C	GLU255
C	GLU258
D	GLU59
D	GLU216
D	GLU255
D	GLU258
A	GLU216
A	GLU255
A	GLU258
B	GLU59
B	GLU216
B	GLU255
B	GLU258
C	GLU59

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:19798051, ECO:0000269|PubMed:28747715, ECO:0007744|PDB:2ZY9, ECO:0007744|PDB:5X9G, ECO:0007744|PDB:5X9H

Chain	Residue	Details
A	ASP91
C	ASP95
C	GLY136
C	ASP247
D	ASP91
D	ASP95
D	GLY136
D	ASP247
A	ASP95
A	GLY136
A	ASP247
B	ASP91
B	ASP95
B	GLY136
B	ASP247
C	ASP91

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:28747715, ECO:0007744|PDB:5X9G, ECO:0007744|PDB:5X9H

Chain	Residue	Details
A	TYR170
B	VAL207
C	TYR170
C	SER185
C	ARG187
C	ASP188
C	VAL207
D	TYR170
D	SER185
D	ARG187
D	ASP188
A	SER185
D	VAL207
A	ARG187
A	ASP188
A	VAL207
B	TYR170
B	SER185
B	ARG187
B	ASP188

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:19798051, ECO:0000269|PubMed:28747715, ECO:0007744|PDB:2ZY9, ECO:0007744|PDB:5X9H

Chain	Residue	Details
A	ALA223
D	ALA223
D	ASP226
D	ASP250
A	ASP226
A	ASP250
B	ALA223
B	ASP226
B	ASP250
C	ALA223
C	ASP226
C	ASP250

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:19798051, ECO:0000269|PubMed:28747715, ECO:0007744|PDB:2ZY9

Chain	Residue	Details
A	ASP259
B	ASP259
C	ASP259
D	ASP259

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:25367295, ECO:0007744|PDB:4U9N

Chain	Residue	Details
A	GLU275
B	GLU275
C	GLU275
D	GLU275

---