5X98
Y162F mutant of thermus thermophilus HB8 thymidylate kinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 201 |
| Chain | Residue |
| B | TYR62 |
| B | SER66 |
| B | ARG69 |
| B | ALA115 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | HOH370 |
| B | THR7 |
| B | GLU9 |
| B | TYR92 |
| B | ASP94 |
| B | THR127 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 203 |
| Chain | Residue |
| B | TYR102 |
| B | ARG112 |
| B | LEU165 |
| B | ASP177 |
| B | THR179 |
| B | HOH404 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 204 |
| Chain | Residue |
| B | GLU160 |
| B | ALA164 |
| B | ARG167 |
| B | HOH411 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 205 |
| Chain | Residue |
| B | GLY13 |
| B | SER14 |
| B | GLY15 |
| B | LYS16 |
| B | THR17 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | TYR62 |
| A | SER66 |
| A | ARG69 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | THR7 |
| A | GLU9 |
| A | TYR92 |
| A | ASP94 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 203 |
| Chain | Residue |
| A | PRO109 |
| A | HOH363 |
| B | PRO170 |
| B | HOH335 |
| B | HOH346 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 204 |
| Chain | Residue |
| A | GLY13 |
| A | SER14 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
| A | HOH322 |
| A | HOH351 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 205 |
| Chain | Residue |
| A | GLU169 |
| A | PRO170 |
| A | GLY171 |
| A | ARG172 |
| B | ALA29 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ISDRYldSSlAYQ |
| Chain | Residue | Details |
| B | ILE88-GLN100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00165 |
| Chain | Residue | Details |
| B | GLY10 | |
| A | GLY10 |
