5X93

Human endothelin receptor type-B in complex with antagonist K-8794

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016998	biological_process	cell wall macromolecule catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue K87 A 1201

Chain	Residue
A	HIS150
A	TRP336
A	LEU339
A	HIS340
A	ARG343
A	ILE372
A	SER376
A	HOH1315
A	HOH1336
A	ASN158
A	VAL177
A	GLN181
A	LYS182
A	VAL185
A	CYS255
A	LYS273
A	TYR281

---

site_id	AC2
Number of Residues	9
Details	binding site for residue OLC A 1202

Chain	Residue
A	CYS109
A	PHE112
A	VAL113
A	ILE117
A	ALA272
A	TRP275
A	SER279
A	TRP404
A	OLC1212

---

site_id	AC3
Number of Residues	4
Details	binding site for residue OLC A 1203

Chain	Residue
A	LYS175
A	OLC1205
A	OLC1207
A	HOH1377

---

site_id	AC4
Number of Residues	1
Details	binding site for residue OLC A 1204

Chain	Residue
A	GLU95

---

site_id	AC5
Number of Residues	3
Details	binding site for residue OLC A 1205

Chain	Residue
A	VAL230
A	OLC1203
A	OLC1211

---

site_id	AC6
Number of Residues	5
Details	binding site for residue OLC A 1206

Chain	Residue
A	VAL231
A	LEU232
A	ILE238
A	THR263
A	TRP276

---

site_id	AC7
Number of Residues	2
Details	binding site for residue OLC A 1207

Chain	Residue
A	GLU172
A	OLC1203

---

site_id	AC8
Number of Residues	5
Details	binding site for residue OLC A 1208

Chain	Residue
A	LEU330
A	VAL331
A	LEU334
A	CYS335
A	OLC1210

---

site_id	AC9
Number of Residues	4
Details	binding site for residue OLC A 1209

Chain	Residue
A	THR99
A	TRP217
A	LEU224
A	OLC1211

---

site_id	AD1
Number of Residues	6
Details	binding site for residue OLC A 1210

Chain	Residue
A	LEU114
A	LYS323
A	ALA381
A	LEU388
A	VAL389
A	OLC1208

---

site_id	AD2
Number of Residues	4
Details	binding site for residue OLC A 1211

Chain	Residue
A	VAL227
A	VAL231
A	OLC1205
A	OLC1209

---

site_id	AD3
Number of Residues	6
Details	binding site for residue OLC A 1212

Chain	Residue
A	VAL152
A	ILE153
A	TYR160
A	TRP275
A	SER279
A	OLC1202

---

site_id	AD4
Number of Residues	6
Details	binding site for residue CLR A 1213

Chain	Residue
A	CYS109
A	LEU110
A	VAL113
A	ALA194
A	GLU221
A	HOH1338

---

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 A 1214

Chain	Residue
A	LYS216
A	THR1099
A	PRO1100
A	ASN1101
A	ARG1102
A	HOH1316

---

site_id	AD6
Number of Residues	2
Details	binding site for residue SO4 A 1215

Chain	Residue
A	ARG1033
A	ARG1037

---

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 A 1216

Chain	Residue
A	PRO136
A	ARG199
A	ARG208
A	LYS210

---

site_id	AD8
Number of Residues	5
Details	binding site for residue SO4 A 1217

Chain	Residue
A	PHE1071
A	THR1072
A	ASN1073
A	SER1074
A	ASN1089

---

site_id	AD9
Number of Residues	6
Details	binding site for residue SO4 A 1218

Chain	Residue
A	HIS314
A	HIS314
A	HOH1302
A	HOH1302
A	HOH1346
A	HOH1346

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ITVlSLCALSIDRYRaV

Chain	Residue	Details
A	ILE187-VAL203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	49
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P28088","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"9261180","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 921

Chain

Residue

Details

---