5X8V
Y92H mutant of thermus thermophilus HB8 thymidylate kinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 201 |
| Chain | Residue |
| B | ASP131 |
| B | ARG159 |
| B | TYR162 |
| B | HOH320 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 202 |
| Chain | Residue |
| B | GLY13 |
| B | GLY15 |
| B | LYS16 |
| B | THR17 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 201 |
| Chain | Residue |
| A | GLU9 |
| A | ASP94 |
| A | HOH404 |
| A | THR7 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 202 |
| Chain | Residue |
| A | TYR62 |
| A | SER66 |
| A | ARG69 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 203 |
| Chain | Residue |
| A | LEU165 |
| A | GLU169 |
| A | HOH378 |
| A | HOH382 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 204 |
| Chain | Residue |
| A | GLY13 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ISDRHldSSlAYQ |
| Chain | Residue | Details |
| B | ILE88-GLN100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00165 |
| Chain | Residue | Details |
| B | GLY10 | |
| A | GLY10 |
