5X8J

K16M mutant of thermus thermophilus HB8 thymidylate kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004798	molecular_function	thymidylate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006227	biological_process	dUDP biosynthetic process
A	0006233	biological_process	dTDP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0004798	molecular_function	thymidylate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006227	biological_process	dUDP biosynthetic process
B	0006233	biological_process	dTDP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue FMT A 201

Chain	Residue
A	GLY13
A	SER14
A	GLY15
A	MET16
A	THR17
A	HOH302
A	HOH327
A	HOH341

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site_id	AC2
Number of Residues	6
Details	binding site for residue FMT B 201

Chain	Residue
B	GLY13
B	SER14
B	GLY15
B	MET16
B	THR17
B	LEU11

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site_id	AC3
Number of Residues	5
Details	binding site for residue FMT B 202

Chain	Residue
B	GLU39
B	PRO40
B	PHE65
B	ASP68
B	ARG69

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Functional Information from PROSITE/UniProt

site_id	PS01331
Number of Residues	13
Details	THYMIDYLATE_KINASE Thymidylate kinase signature. ISDRYldSSlAYQ

Chain	Residue	Details
A	ILE88-GLN100

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00165

Chain	Residue	Details
A	GLY10
B	GLY10

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