5X54

Crystal structure of the Keap1 Kelch domain in complex with a tetrapeptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0008134	molecular_function	transcription factor binding
B	0016567	biological_process	protein ubiquitination
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ACT B 901

Chain	Residue
B	TYR491
B	PRO492
B	GLU493
B	ARG494
B	HOH1065

---

site_id	AC2
Number of Residues	2
Details	binding site for residue ACT B 902

Chain	Residue
B	ASP357
B	ARG470

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site_id	AC3
Number of Residues	11
Details	binding site for Di-peptide ACE C 0 and GLU C 1

Chain	Residue
A	SER508
A	ASP587
A	THR588
C	TRP2
C	TRP3
C	TRP4
C	HOH101
C	HOH103
C	HOH104
A	ARG415
A	ARG483

---

site_id	AC4
Number of Residues	7
Details	binding site for Di-peptide ACE D 0 and GLU D 1

Chain	Residue
B	ARG415
B	ARG483
B	SER508
D	TRP2
D	TRP3
D	TRP4
D	HOH101

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	90
Details	Repeat: {"description":"Kelch 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	100
Details	Repeat: {"description":"Kelch 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	92
Details	Repeat: {"description":"Kelch 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	92
Details	Repeat: {"description":"Kelch 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	92
Details	Repeat: {"description":"Kelch 5"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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