Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5X06

DNA replication regulation protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006271	biological_process	DNA strand elongation involved in DNA replication
A	0006974	biological_process	DNA damage response
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009360	cellular_component	DNA polymerase III complex
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0030894	cellular_component	replisome
A	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
A	0042276	biological_process	error-prone translesion synthesis
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044787	biological_process	bacterial-type DNA replication
A	1990078	cellular_component	replication inhibiting complex
A	1990085	cellular_component	Hda-beta clamp complex
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006974	biological_process	DNA damage response
B	0008408	molecular_function	3'-5' exonuclease activity
B	0009360	cellular_component	DNA polymerase III complex
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0030894	cellular_component	replisome
B	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
B	0042276	biological_process	error-prone translesion synthesis
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044787	biological_process	bacterial-type DNA replication
B	1990078	cellular_component	replication inhibiting complex
B	1990085	cellular_component	Hda-beta clamp complex
C	0003677	molecular_function	DNA binding
C	0003887	molecular_function	DNA-directed DNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006271	biological_process	DNA strand elongation involved in DNA replication
C	0006974	biological_process	DNA damage response
C	0008408	molecular_function	3'-5' exonuclease activity
C	0009360	cellular_component	DNA polymerase III complex
C	0030174	biological_process	regulation of DNA-templated DNA replication initiation
C	0030894	cellular_component	replisome
C	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
C	0042276	biological_process	error-prone translesion synthesis
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0044787	biological_process	bacterial-type DNA replication
C	1990078	cellular_component	replication inhibiting complex
C	1990085	cellular_component	Hda-beta clamp complex
D	0003677	molecular_function	DNA binding
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006271	biological_process	DNA strand elongation involved in DNA replication
D	0006974	biological_process	DNA damage response
D	0008408	molecular_function	3'-5' exonuclease activity
D	0009360	cellular_component	DNA polymerase III complex
D	0030174	biological_process	regulation of DNA-templated DNA replication initiation
D	0030894	cellular_component	replisome
D	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
D	0042276	biological_process	error-prone translesion synthesis
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0044787	biological_process	bacterial-type DNA replication
D	1990078	cellular_component	replication inhibiting complex
D	1990085	cellular_component	Hda-beta clamp complex
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006260	biological_process	DNA replication
E	0006270	biological_process	DNA replication initiation
E	0008156	biological_process	negative regulation of DNA replication
E	0016020	cellular_component	membrane
E	0030174	biological_process	regulation of DNA-templated DNA replication initiation
E	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
E	0042802	molecular_function	identical protein binding
E	0043531	molecular_function	ADP binding
E	1990078	cellular_component	replication inhibiting complex
E	1990085	cellular_component	Hda-beta clamp complex
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006260	biological_process	DNA replication
F	0006270	biological_process	DNA replication initiation
F	0008156	biological_process	negative regulation of DNA replication
F	0016020	cellular_component	membrane
F	0030174	biological_process	regulation of DNA-templated DNA replication initiation
F	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
F	0042802	molecular_function	identical protein binding
F	0043531	molecular_function	ADP binding
F	1990078	cellular_component	replication inhibiting complex
F	1990085	cellular_component	Hda-beta clamp complex
G	0000166	molecular_function	nucleotide binding
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006260	biological_process	DNA replication
G	0006270	biological_process	DNA replication initiation
G	0008156	biological_process	negative regulation of DNA replication
G	0016020	cellular_component	membrane
G	0030174	biological_process	regulation of DNA-templated DNA replication initiation
G	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
G	0042802	molecular_function	identical protein binding
G	0043531	molecular_function	ADP binding
G	1990078	cellular_component	replication inhibiting complex
G	1990085	cellular_component	Hda-beta clamp complex
H	0000166	molecular_function	nucleotide binding
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006260	biological_process	DNA replication
H	0006270	biological_process	DNA replication initiation
H	0008156	biological_process	negative regulation of DNA replication
H	0016020	cellular_component	membrane
H	0030174	biological_process	regulation of DNA-templated DNA replication initiation
H	0032297	biological_process	negative regulation of DNA-templated DNA replication initiation
H	0042802	molecular_function	identical protein binding
H	0043531	molecular_function	ADP binding
H	1990078	cellular_component	replication inhibiting complex
H	1990085	cellular_component	Hda-beta clamp complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue GOL C 401

Chain	Residue
C	GLN265

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL D 401

Chain	Residue
D	GLU50
D	LYS198
H	THR83

site_id	AC3
Number of Residues	15
Details	binding site for residue ADP E 1001

Chain	Residue
E	ALA54
E	GLY55
E	ARG56
E	SER57
E	HIS58
E	LEU165
E	ARG177
E	PHE205
E	MG1002
E	HOH1101
E	GLU17
E	SER21
E	PHE22
E	TRP23
E	GLY53

site_id	AC4
Number of Residues	3
Details	binding site for residue MG E 1002

Chain	Residue
E	SER57
E	ADP1001
E	HOH1101

site_id	AC5
Number of Residues	2
Details	binding site for residue GOL E 1003

Chain	Residue
A	GLU50
E	THR83

site_id	AC6
Number of Residues	17
Details	binding site for residue ADP F 1001

Chain	Residue
F	GLU17
F	SER21
F	PHE22
F	TRP23
F	GLY53
F	ALA54
F	GLY55
F	ARG56
F	SER57
F	HIS58
F	LEU165
F	ARG177
F	MET201
F	ARG202
F	PHE205
F	MG1002
F	HOH1102

site_id	AC7
Number of Residues	3
Details	binding site for residue MG F 1002

Chain	Residue
F	SER57
F	ADP1001
F	HOH1102

site_id	AC8
Number of Residues	16
Details	binding site for residue ADP G 1001

Chain	Residue
G	GLU17
G	SER21
G	PHE22
G	TRP23
G	GLY53
G	ALA54
G	GLY55
G	ARG56
G	SER57
G	HIS58
G	ARG177
G	MET201
G	ARG202
G	PHE205
G	MG1002
G	HOH1101

site_id	AC9
Number of Residues	3
Details	binding site for residue MG G 1002

Chain	Residue
G	SER57
G	ADP1001
G	HOH1101

site_id	AD1
Number of Residues	2
Details	binding site for residue GOL G 1003

Chain	Residue
C	GLU50
G	THR83

site_id	AD2
Number of Residues	16
Details	binding site for residue ADP H 1001

Chain	Residue
H	GLU17
H	SER21
H	PHE22
H	TRP23
H	GLY53
H	ALA54
H	GLY55
H	ARG56
H	SER57
H	HIS58
H	LEU165
H	ARG177
H	ARG202
H	PHE205
H	MG1002
H	HOH1101

site_id	AD3
Number of Residues	3
Details	binding site for residue MG H 1002

Chain	Residue
H	SER57
H	ADP1001
H	HOH1101

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305\|PubMed:18191219

Chain	Residue	Details
A	ARG24
D	ARG24
D	GLN149
D	TYR153
A	GLN149
A	TYR153
B	ARG24
B	GLN149
B	TYR153
C	ARG24
C	GLN149
C	TYR153

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:18191219

Chain	Residue	Details
A	ARG73
B	ARG73
C	ARG73
D	ARG73

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)