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5WZT

Crystal structure of human secreted phospholipase A2 group IIE with Compound 14

Functional Information from GO Data
ChainGOidnamespacecontents
A0004623molecular_functionphospholipase A2 activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0006629biological_processlipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006954biological_processinflammatory response
A0016042biological_processlipid catabolic process
A0016787molecular_functionhydrolase activity
A0034374biological_processlow-density lipoprotein particle remodeling
A0046470biological_processphosphatidylcholine metabolic process
A0046471biological_processphosphatidylglycerol metabolic process
A0046872molecular_functionmetal ion binding
A0047498molecular_functioncalcium-dependent phospholipase A2 activity
A0050482biological_processarachidonate secretion
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue CA A 201
ChainResidue
ATYR26
AGLY28
AGLY30
AASP47
A7W6204

site_idAC2
Number of Residues5
Detailsbinding site for residue GOL A 202
ChainResidue
AHOH315
ACYS49
AARG52
AARG92
AHOH315

site_idAC3
Number of Residues5
Detailsbinding site for residue DMS A 203
ChainResidue
AHIS44
ACYS48
ATHR120
APRO121
ACYS123

site_idAC4
Number of Residues18
Detailsbinding site for residue 7W6 A 204
ChainResidue
ALEU2
APHE5
AGLY6
AILE9
AALA17
ATYR20
AASN21
ATYR26
ACYS27
AGLY28
AILE29
AGLY30
ACYS43
AHIS46
AASP47
ALYS61
APHE97
ACA201

Functional Information from PROSITE/UniProt
site_idPS00118
Number of Residues8
DetailsPA2_HIS Phospholipase A2 histidine active site. CCHaHDcC
ChainResidueDetails
ACYS42-CYS49

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28883454","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WZM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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