5WZO

Crystal structure of human secreted phospholipase A2 group IIE, crystallized with calcium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004623	molecular_function	phospholipase A2 activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006954	biological_process	inflammatory response
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0034374	biological_process	low-density lipoprotein particle remodeling
A	0042130	biological_process	negative regulation of T cell proliferation
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0050482	biological_process	arachidonate secretion

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 201

Chain	Residue
A	GOL212
A	GOL212

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 202

Chain	Residue
A	SER68
A	VAL69
A	GOL213
A	B3P214

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 203

Chain	Residue
A	GLY73
A	ARG98

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 204

Chain	Residue
A	CYS49
A	ARG52
A	ARG92
A	ALA45

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 205

Chain	Residue
A	LYS15
A	ARG106
A	HOH430

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CL A 206

Chain	Residue
A	GLY73
A	ILE74
A	LYS91
A	HOH463

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CL A 207

Chain	Residue
A	ARG106
A	HOH425
A	HOH441
A	HOH460

---

site_id	AC8
Number of Residues	2
Details	binding site for residue CL A 208

Chain	Residue
A	ARG79
A	GLN83

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CL A 209

Chain	Residue
A	THR80
A	THR81
A	THR81
A	CYS82
A	HOH465

---

site_id	AD1
Number of Residues	6
Details	binding site for residue CA A 210

Chain	Residue
A	TYR26
A	GLY28
A	GLY30
A	ASP47
A	HOH341
A	HOH397

---

site_id	AD2
Number of Residues	5
Details	binding site for residue CA A 211

Chain	Residue
A	ASP22
A	TYR23
A	GLY24
A	TYR111
A	HOH358

---

site_id	AD3
Number of Residues	7
Details	binding site for residue GOL A 212

Chain	Residue
A	CYS49
A	ARG52
A	GLU88
A	ARG92
A	CL201
A	CL201
A	HOH313

---

site_id	AD4
Number of Residues	8
Details	binding site for residue GOL A 213

Chain	Residue
A	GLN4
A	LYS64
A	TYR65
A	SER68
A	GLN83
A	CL202
A	B3P214
A	HOH307

---

site_id	AD5
Number of Residues	9
Details	binding site for residue B3P A 214

Chain	Residue
A	GLN4
A	GLN4
A	TYR65
A	LEU66
A	LEU66
A	PHE67
A	PHE67
A	CL202
A	GOL213

---

Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCHaHDcC

Chain	Residue	Details
A	CYS42-CYS49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10035

Chain	Residue	Details
A	HIS46
A	ASP90

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:28883454, ECO:0007744|PDB:5WZM

Chain	Residue	Details
A	ASP22
A	GLY24
A	TYR26
A	GLY28
A	GLY30
A	ASP47
A	TYR111
A	ASN113

---