5WZ1
Crystal structure of Zika virus NS5 methyltransferase bound to S-adenosyl-L-methionine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | methyltransferase cap1 activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | methyltransferase cap1 activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| C | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| C | 0004483 | molecular_function | methyltransferase cap1 activity |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0032259 | biological_process | methylation |
| D | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| D | 0004483 | molecular_function | methyltransferase cap1 activity |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0032259 | biological_process | methylation |
| E | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| E | 0004483 | molecular_function | methyltransferase cap1 activity |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0032259 | biological_process | methylation |
| F | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| F | 0004483 | molecular_function | methyltransferase cap1 activity |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0032259 | biological_process | methylation |
| G | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| G | 0004483 | molecular_function | methyltransferase cap1 activity |
| G | 0008168 | molecular_function | methyltransferase activity |
| G | 0032259 | biological_process | methylation |
| H | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| H | 0004483 | molecular_function | methyltransferase cap1 activity |
| H | 0008168 | molecular_function | methyltransferase activity |
| H | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue SAM A 601 |
| Chain | Residue |
| A | SER58 |
| A | GLU113 |
| A | VAL132 |
| A | ASP133 |
| A | VAL134 |
| A | PHE135 |
| A | ASP148 |
| A | ILE149 |
| A | GLY60 |
| A | GLY83 |
| A | CYS84 |
| A | GLY88 |
| A | TRP89 |
| A | THR106 |
| A | LYS107 |
| A | HIS112 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue SAM B 601 |
| Chain | Residue |
| B | SER58 |
| B | GLY60 |
| B | GLY83 |
| B | CYS84 |
| B | GLY88 |
| B | TRP89 |
| B | THR106 |
| B | LYS107 |
| B | HIS112 |
| B | GLU113 |
| B | VAL132 |
| B | ASP133 |
| B | VAL134 |
| B | PHE135 |
| B | ASP148 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue SAM C 601 |
| Chain | Residue |
| C | SER58 |
| C | GLY60 |
| C | GLY83 |
| C | CYS84 |
| C | GLY88 |
| C | TRP89 |
| C | THR106 |
| C | LYS107 |
| C | HIS112 |
| C | GLU113 |
| C | VAL132 |
| C | ASP133 |
| C | VAL134 |
| C | PHE135 |
| C | ASP148 |
| C | ILE149 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue SAM D 601 |
| Chain | Residue |
| D | SER58 |
| D | GLY60 |
| D | GLY83 |
| D | CYS84 |
| D | GLY88 |
| D | TRP89 |
| D | THR106 |
| D | LYS107 |
| D | HIS112 |
| D | GLU113 |
| D | VAL132 |
| D | ASP133 |
| D | VAL134 |
| D | PHE135 |
| D | ASP148 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue SAM E 601 |
| Chain | Residue |
| E | SER58 |
| E | GLY60 |
| E | GLY83 |
| E | CYS84 |
| E | GLY88 |
| E | TRP89 |
| E | THR106 |
| E | LYS107 |
| E | HIS112 |
| E | GLU113 |
| E | VAL132 |
| E | ASP133 |
| E | VAL134 |
| E | PHE135 |
| E | ASP148 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue SAM F 601 |
| Chain | Residue |
| F | SER58 |
| F | GLY60 |
| F | GLY83 |
| F | CYS84 |
| F | GLY88 |
| F | TRP89 |
| F | THR106 |
| F | LYS107 |
| F | HIS112 |
| F | GLU113 |
| F | VAL132 |
| F | ASP133 |
| F | VAL134 |
| F | PHE135 |
| F | ASP148 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue SAM G 601 |
| Chain | Residue |
| G | LYS107 |
| G | HIS112 |
| G | GLU113 |
| G | VAL132 |
| G | ASP133 |
| G | VAL134 |
| G | PHE135 |
| G | ASP148 |
| G | ILE149 |
| G | SER58 |
| G | GLY60 |
| G | GLY83 |
| G | CYS84 |
| G | GLY88 |
| G | TRP89 |
| G | THR106 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue SAM H 601 |
| Chain | Residue |
| H | SER58 |
| H | GLY60 |
| H | GLY83 |
| H | CYS84 |
| H | GLY88 |
| H | TRP89 |
| H | THR106 |
| H | LYS107 |
| H | HIS112 |
| H | GLU113 |
| H | VAL132 |
| H | ASP133 |
| H | VAL134 |
| H | PHE135 |
| H | ASP148 |
