5WWV
Crystal structure of porcine kidney D-amino acid oxidase mutant (I230A/R283G)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003884 | molecular_function | D-amino-acid oxidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005782 | cellular_component | peroxisomal matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0006562 | biological_process | proline catabolic process |
| A | 0007586 | biological_process | digestion |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019478 | biological_process | D-amino acid catabolic process |
| A | 0036088 | biological_process | D-serine catabolic process |
| A | 0042416 | biological_process | dopamine biosynthetic process |
| A | 0042995 | cellular_component | cell projection |
| A | 0045202 | cellular_component | synapse |
| A | 0046416 | biological_process | D-amino acid metabolic process |
| A | 0048786 | cellular_component | presynaptic active zone |
| A | 0055130 | biological_process | D-alanine catabolic process |
| A | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| A | 0071949 | molecular_function | FAD binding |
| B | 0003884 | molecular_function | D-amino-acid oxidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005782 | cellular_component | peroxisomal matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0006562 | biological_process | proline catabolic process |
| B | 0007586 | biological_process | digestion |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019478 | biological_process | D-amino acid catabolic process |
| B | 0036088 | biological_process | D-serine catabolic process |
| B | 0042416 | biological_process | dopamine biosynthetic process |
| B | 0042995 | cellular_component | cell projection |
| B | 0045202 | cellular_component | synapse |
| B | 0046416 | biological_process | D-amino acid metabolic process |
| B | 0048786 | cellular_component | presynaptic active zone |
| B | 0055130 | biological_process | D-alanine catabolic process |
| B | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| B | 0071949 | molecular_function | FAD binding |
| C | 0003884 | molecular_function | D-amino-acid oxidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005777 | cellular_component | peroxisome |
| C | 0005782 | cellular_component | peroxisomal matrix |
| C | 0005829 | cellular_component | cytosol |
| C | 0006562 | biological_process | proline catabolic process |
| C | 0007586 | biological_process | digestion |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019478 | biological_process | D-amino acid catabolic process |
| C | 0036088 | biological_process | D-serine catabolic process |
| C | 0042416 | biological_process | dopamine biosynthetic process |
| C | 0042995 | cellular_component | cell projection |
| C | 0045202 | cellular_component | synapse |
| C | 0046416 | biological_process | D-amino acid metabolic process |
| C | 0048786 | cellular_component | presynaptic active zone |
| C | 0055130 | biological_process | D-alanine catabolic process |
| C | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| C | 0071949 | molecular_function | FAD binding |
| D | 0003884 | molecular_function | D-amino-acid oxidase activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005777 | cellular_component | peroxisome |
| D | 0005782 | cellular_component | peroxisomal matrix |
| D | 0005829 | cellular_component | cytosol |
| D | 0006562 | biological_process | proline catabolic process |
| D | 0007586 | biological_process | digestion |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019478 | biological_process | D-amino acid catabolic process |
| D | 0036088 | biological_process | D-serine catabolic process |
| D | 0042416 | biological_process | dopamine biosynthetic process |
| D | 0042995 | cellular_component | cell projection |
| D | 0045202 | cellular_component | synapse |
| D | 0046416 | biological_process | D-amino acid metabolic process |
| D | 0048786 | cellular_component | presynaptic active zone |
| D | 0055130 | biological_process | D-alanine catabolic process |
| D | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| D | 0071949 | molecular_function | FAD binding |
| E | 0003884 | molecular_function | D-amino-acid oxidase activity |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005777 | cellular_component | peroxisome |
| E | 0005782 | cellular_component | peroxisomal matrix |
| E | 0005829 | cellular_component | cytosol |
| E | 0006562 | biological_process | proline catabolic process |
| E | 0007586 | biological_process | digestion |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0019478 | biological_process | D-amino acid catabolic process |
| E | 0036088 | biological_process | D-serine catabolic process |
| E | 0042416 | biological_process | dopamine biosynthetic process |
| E | 0042995 | cellular_component | cell projection |
| E | 0045202 | cellular_component | synapse |
| E | 0046416 | biological_process | D-amino acid metabolic process |
| E | 0048786 | cellular_component | presynaptic active zone |
| E | 0055130 | biological_process | D-alanine catabolic process |
| E | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| E | 0071949 | molecular_function | FAD binding |
| F | 0003884 | molecular_function | D-amino-acid oxidase activity |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005777 | cellular_component | peroxisome |
| F | 0005782 | cellular_component | peroxisomal matrix |
| F | 0005829 | cellular_component | cytosol |
| F | 0006562 | biological_process | proline catabolic process |
| F | 0007586 | biological_process | digestion |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0019478 | biological_process | D-amino acid catabolic process |
| F | 0036088 | biological_process | D-serine catabolic process |
| F | 0042416 | biological_process | dopamine biosynthetic process |
| F | 0042995 | cellular_component | cell projection |
| F | 0045202 | cellular_component | synapse |
| F | 0046416 | biological_process | D-amino acid metabolic process |
| F | 0048786 | cellular_component | presynaptic active zone |
| F | 0055130 | biological_process | D-alanine catabolic process |
| F | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| F | 0071949 | molecular_function | FAD binding |
| G | 0003884 | molecular_function | D-amino-acid oxidase activity |
| G | 0005576 | cellular_component | extracellular region |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005777 | cellular_component | peroxisome |
| G | 0005782 | cellular_component | peroxisomal matrix |
| G | 0005829 | cellular_component | cytosol |
| G | 0006562 | biological_process | proline catabolic process |
| G | 0007586 | biological_process | digestion |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0019478 | biological_process | D-amino acid catabolic process |
| G | 0036088 | biological_process | D-serine catabolic process |
| G | 0042416 | biological_process | dopamine biosynthetic process |
| G | 0042995 | cellular_component | cell projection |
| G | 0045202 | cellular_component | synapse |
| G | 0046416 | biological_process | D-amino acid metabolic process |
| G | 0048786 | cellular_component | presynaptic active zone |
| G | 0055130 | biological_process | D-alanine catabolic process |
| G | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| G | 0071949 | molecular_function | FAD binding |
| H | 0003884 | molecular_function | D-amino-acid oxidase activity |
| H | 0005576 | cellular_component | extracellular region |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005777 | cellular_component | peroxisome |
| H | 0005782 | cellular_component | peroxisomal matrix |
| H | 0005829 | cellular_component | cytosol |
| H | 0006562 | biological_process | proline catabolic process |
| H | 0007586 | biological_process | digestion |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0019478 | biological_process | D-amino acid catabolic process |
| H | 0036088 | biological_process | D-serine catabolic process |
| H | 0042416 | biological_process | dopamine biosynthetic process |
| H | 0042995 | cellular_component | cell projection |
| H | 0045202 | cellular_component | synapse |
| H | 0046416 | biological_process | D-amino acid metabolic process |
| H | 0048786 | cellular_component | presynaptic active zone |
| H | 0055130 | biological_process | D-alanine catabolic process |
| H | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
| H | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue FAD A 401 |
| Chain | Residue |
| A | ILE6 |
| A | THR43 |
| A | THR44 |
| A | THR45 |
| A | ALA48 |
| A | GLY50 |
| A | LEU51 |
| A | ARG162 |
| A | VAL164 |
| A | CYS181 |
| A | THR182 |
| A | GLY7 |
| A | GLY183 |
| A | TRP185 |
| A | ILE202 |
| A | GLY312 |
| A | GLY313 |
| A | TYR314 |
| A | GLY315 |
| A | LEU316 |
| A | THR317 |
| A | 7V3402 |
| A | ALA8 |
| A | GLY9 |
| A | VAL10 |
| A | ILE11 |
| A | ALA36 |
| A | ASP37 |
| A | ARG38 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 7V3 A 402 |
| Chain | Residue |
| A | LEU51 |
| A | ILE215 |
| A | TYR224 |
| A | TYR228 |
| A | ALA230 |
| A | PHE242 |
| A | GLY313 |
| A | FAD401 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MPD A 403 |
| Chain | Residue |
| A | PRO41 |
| A | ASP46 |
| A | ARG142 |
| A | LYS204 |
| A | MPD404 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MPD A 404 |
| Chain | Residue |
| A | PRO41 |
| A | PHE42 |
| A | VAL47 |
| A | TYR279 |
| A | THR280 |
| A | MPD403 |
| B | ASN251 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MPD A 405 |
| Chain | Residue |
| A | PHE39 |
| A | PHE159 |
| A | LEU161 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue MPD A 406 |
| Chain | Residue |
| A | LEU161 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | THR118 |
| A | PRO119 |
| A | ARG120 |
| site_id | AC8 |
| Number of Residues | 28 |
| Details | binding site for residue FAD B 401 |
| Chain | Residue |
| B | ILE6 |
| B | GLY7 |
| B | ALA8 |
| B | GLY9 |
| B | VAL10 |
| B | ILE11 |
| B | ASP37 |
| B | ARG38 |
| B | THR43 |
| B | THR44 |
| B | THR45 |
| B | ALA48 |
| B | GLY50 |
| B | LEU51 |
| B | ARG162 |
| B | VAL164 |
| B | CYS181 |
| B | THR182 |
| B | GLY183 |
| B | TRP185 |
| B | TYR228 |
| B | GLY312 |
| B | GLY313 |
| B | TYR314 |
| B | GLY315 |
| B | LEU316 |
| B | THR317 |
| B | HOH503 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue MPD B 402 |
| Chain | Residue |
| A | ILE253 |
| A | HIS256 |
| B | ARG38 |
| B | PHE42 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue MPD B 403 |
| Chain | Residue |
| A | LYS274 |
| B | ARG142 |
| B | LYS143 |
| site_id | AD2 |
| Number of Residues | 31 |
| Details | binding site for residue FAD C 401 |
| Chain | Residue |
| C | THR43 |
| C | THR44 |
| C | THR45 |
| C | ALA48 |
| C | ALA49 |
| C | GLY50 |
| C | LEU51 |
| C | ARG162 |
| C | VAL164 |
| C | CYS181 |
| C | THR182 |
| C | GLY183 |
| C | TRP185 |
| C | ILE202 |
| C | GLY281 |
| C | HIS311 |
| C | GLY312 |
| C | GLY313 |
| C | TYR314 |
| C | GLY315 |
| C | LEU316 |
| C | THR317 |
| C | 7V3402 |
| C | GLY7 |
| C | ALA8 |
| C | GLY9 |
| C | VAL10 |
| C | ILE11 |
| C | ALA36 |
| C | ASP37 |
| C | ARG38 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue 7V3 C 402 |
| Chain | Residue |
| C | ALA49 |
| C | LEU51 |
| C | ILE215 |
| C | TYR224 |
| C | TYR228 |
| C | ALA230 |
| C | PHE242 |
| C | GLY313 |
| C | FAD401 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue MPD C 403 |
| Chain | Residue |
| C | PRO41 |
| C | PHE42 |
| C | THR280 |
| E | ASN251 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 404 |
| Chain | Residue |
| C | THR118 |
| C | PRO119 |
| C | ARG120 |
| site_id | AD6 |
| Number of Residues | 28 |
| Details | binding site for residue FAD D 401 |
| Chain | Residue |
| D | ALA8 |
| D | GLY9 |
| D | VAL10 |
| D | ILE11 |
| D | ALA36 |
| D | ASP37 |
| D | ARG38 |
| D | THR44 |
| D | THR45 |
| D | ALA48 |
| D | ALA49 |
| D | GLY50 |
| D | LEU51 |
| D | ARG162 |
| D | VAL164 |
| D | CYS181 |
| D | THR182 |
| D | GLY183 |
| D | TRP185 |
| D | ILE202 |
| D | GLY312 |
| D | GLY313 |
| D | TYR314 |
| D | GLY315 |
| D | LEU316 |
| D | THR317 |
| D | 7V3402 |
| D | HOH504 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue 7V3 D 402 |
| Chain | Residue |
| D | LEU51 |
| D | ILE215 |
| D | TYR224 |
| D | TYR228 |
| D | PHE242 |
| D | GLY313 |
| D | FAD401 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue MPD D 403 |
| Chain | Residue |
| C | GLU165 |
| D | ASP37 |
| D | TRP185 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue MPD D 404 |
| Chain | Residue |
| D | PHE159 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 405 |
| Chain | Residue |
| D | THR118 |
| D | PRO119 |
| D | ARG120 |
| site_id | AE2 |
| Number of Residues | 28 |
| Details | binding site for residue FAD E 401 |
| Chain | Residue |
| E | GLY7 |
| E | ALA8 |
| E | GLY9 |
| E | VAL10 |
| E | ILE11 |
| E | ALA36 |
| E | ASP37 |
| E | ARG38 |
| E | THR44 |
| E | THR45 |
| E | ALA48 |
| E | ALA49 |
| E | GLY50 |
| E | LEU51 |
| E | ARG162 |
| E | VAL164 |
| E | THR182 |
| E | GLY183 |
| E | TRP185 |
| E | GLY281 |
| E | PRO284 |
| E | GLY312 |
| E | GLY313 |
| E | TYR314 |
| E | GLY315 |
| E | LEU316 |
| E | THR317 |
| E | MPD402 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue MPD E 402 |
| Chain | Residue |
| E | TYR224 |
| E | TYR228 |
| E | GLY313 |
| E | FAD401 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue MPD E 403 |
| Chain | Residue |
| E | PRO41 |
| E | LYS204 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue MPD E 404 |
| Chain | Residue |
| E | ASP37 |
| E | ARG38 |
| E | LYS163 |
| F | GLU165 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 E 405 |
| Chain | Residue |
| E | THR118 |
| E | PRO119 |
| E | ARG120 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue MPD E 406 |
| Chain | Residue |
| E | LEU161 |
| F | SER166 |
| F | GLU168 |
| F | GLU169 |
| F | ARG172 |
| site_id | AE8 |
| Number of Residues | 30 |
| Details | binding site for residue FAD F 401 |
| Chain | Residue |
| F | GLY7 |
| F | ALA8 |
| F | GLY9 |
| F | VAL10 |
| F | ILE11 |
| F | ALA36 |
| F | ASP37 |
| F | ARG38 |
| F | THR43 |
| F | THR44 |
| F | THR45 |
| F | ALA48 |
| F | ALA49 |
| F | GLY50 |
| F | LEU51 |
| F | ARG162 |
| F | LYS163 |
| F | VAL164 |
| F | CYS181 |
| F | THR182 |
| F | GLY183 |
| F | TRP185 |
| F | HIS311 |
| F | GLY312 |
| F | GLY313 |
| F | TYR314 |
| F | GLY315 |
| F | LEU316 |
| F | THR317 |
| F | 7V3402 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue 7V3 F 402 |
| Chain | Residue |
| F | ALA49 |
| F | ILE215 |
| F | TYR224 |
| F | TYR228 |
| F | ALA230 |
| F | PHE242 |
| F | GLY313 |
| F | FAD401 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue MPD F 403 |
| Chain | Residue |
| D | ARG38 |
| D | PHE42 |
| F | ASN252 |
| F | ILE253 |
| F | HIS256 |
| site_id | AF2 |
| Number of Residues | 1 |
| Details | binding site for residue MPD F 404 |
| Chain | Residue |
| F | ASP46 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue MPD F 405 |
| Chain | Residue |
| D | ASN251 |
| F | PHE42 |
| F | THR280 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 F 406 |
| Chain | Residue |
| F | THR118 |
| F | ARG120 |
| site_id | AF5 |
| Number of Residues | 27 |
| Details | binding site for residue FAD G 401 |
| Chain | Residue |
| G | GLY7 |
| G | ALA8 |
| G | GLY9 |
| G | VAL10 |
| G | ILE11 |
| G | ASP37 |
| G | ARG38 |
| G | THR43 |
| G | THR44 |
| G | THR45 |
| G | ALA48 |
| G | ALA49 |
| G | GLY50 |
| G | LEU51 |
| G | VAL164 |
| G | THR182 |
| G | GLY183 |
| G | TRP185 |
| G | ILE202 |
| G | PRO284 |
| G | GLY312 |
| G | GLY313 |
| G | TYR314 |
| G | GLY315 |
| G | LEU316 |
| G | THR317 |
| G | 7V3402 |
| site_id | AF6 |
| Number of Residues | 8 |
| Details | binding site for residue 7V3 G 402 |
| Chain | Residue |
| G | ALA49 |
| G | LEU51 |
| G | ILE215 |
| G | TYR224 |
| G | TYR228 |
| G | PHE242 |
| G | GLY313 |
| G | FAD401 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue MPD G 403 |
| Chain | Residue |
| G | PRO41 |
| G | LYS204 |
| G | TYR279 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue MPD G 404 |
| Chain | Residue |
| G | ASP37 |
| G | ARG38 |
| G | LYS163 |
| G | TRP185 |
| H | GLU165 |
| site_id | AF9 |
| Number of Residues | 29 |
| Details | binding site for residue FAD H 401 |
| Chain | Residue |
| H | GLY7 |
| H | ALA8 |
| H | GLY9 |
| H | VAL10 |
| H | ILE11 |
| H | ALA36 |
| H | ASP37 |
| H | ARG38 |
| H | THR43 |
| H | THR44 |
| H | THR45 |
| H | ALA48 |
| H | GLY50 |
| H | LEU51 |
| H | ARG162 |
| H | VAL164 |
| H | CYS181 |
| H | THR182 |
| H | GLY183 |
| H | TRP185 |
| H | HIS311 |
| H | GLY312 |
| H | GLY313 |
| H | TYR314 |
| H | GLY315 |
| H | LEU316 |
| H | THR317 |
| H | MPD402 |
| H | HOH502 |
| site_id | AG1 |
| Number of Residues | 3 |
| Details | binding site for residue MPD H 402 |
| Chain | Residue |
| H | TYR224 |
| H | GLY313 |
| H | FAD401 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue MPD H 403 |
| Chain | Residue |
| H | ARG142 |
| H | LYS204 |
| H | TYR279 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue MPD H 404 |
| Chain | Residue |
| G | ASN251 |
| H | PRO41 |
| H | TYR279 |
| H | THR280 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 H 405 |
| Chain | Residue |
| H | THR118 |
| H | PRO119 |
| H | ARG120 |
Functional Information from PROSITE/UniProt
| site_id | PS00677 |
| Number of Residues | 19 |
| Details | DAO D-amino acid oxidases signature. VIHNYGhGGyGltihwGcA |
| Chain | Residue | Details |
| A | VAL305-ALA323 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 64 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10876160, ECO:0000269|PubMed:24644036, ECO:0000269|PubMed:27648606, ECO:0000269|PubMed:30333894, ECO:0000269|PubMed:8755502, ECO:0000269|PubMed:9153426, ECO:0000269|PubMed:9399588, ECO:0007744|PDB:1AN9, ECO:0007744|PDB:1DDO, ECO:0007744|PDB:1EVI, ECO:0007744|PDB:1KIF, ECO:0007744|PDB:1VE9, ECO:0007744|PDB:3WGT, ECO:0007744|PDB:4YJD, ECO:0007744|PDB:4YJF, ECO:0007744|PDB:4YJG, ECO:0007744|PDB:4YJH, ECO:0007744|PDB:5WWV, ECO:0007744|PDB:5WX2 |
| Chain | Residue | Details |
| A | ALA8 | |
| B | ASP37 | |
| B | THR45 | |
| B | LEU51 | |
| B | VAL164 | |
| B | GLY312 | |
| B | GLY315 | |
| B | THR317 | |
| C | ALA8 | |
| C | ASP37 | |
| C | THR45 | |
| A | ASP37 | |
| C | LEU51 | |
| C | VAL164 | |
| C | GLY312 | |
| C | GLY315 | |
| C | THR317 | |
| D | ALA8 | |
| D | ASP37 | |
| D | THR45 | |
| D | LEU51 | |
| D | VAL164 | |
| A | THR45 | |
| D | GLY312 | |
| D | GLY315 | |
| D | THR317 | |
| E | ALA8 | |
| E | ASP37 | |
| E | THR45 | |
| E | LEU51 | |
| E | VAL164 | |
| E | GLY312 | |
| E | GLY315 | |
| A | LEU51 | |
| E | THR317 | |
| F | ALA8 | |
| F | ASP37 | |
| F | THR45 | |
| F | LEU51 | |
| F | VAL164 | |
| F | GLY312 | |
| F | GLY315 | |
| F | THR317 | |
| G | ALA8 | |
| A | VAL164 | |
| G | ASP37 | |
| G | THR45 | |
| G | LEU51 | |
| G | VAL164 | |
| G | GLY312 | |
| G | GLY315 | |
| G | THR317 | |
| H | ALA8 | |
| H | ASP37 | |
| H | THR45 | |
| A | GLY312 | |
| H | LEU51 | |
| H | VAL164 | |
| H | GLY312 | |
| H | GLY315 | |
| H | THR317 | |
| A | GLY315 | |
| A | THR317 | |
| B | ALA8 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P14920 |
| Chain | Residue | Details |
| A | GLY9 | |
| B | GLY283 | |
| C | GLY9 | |
| C | THR43 | |
| C | GLN53 | |
| C | THR182 | |
| C | GLY283 | |
| D | GLY9 | |
| D | THR43 | |
| D | GLN53 | |
| D | THR182 | |
| A | THR43 | |
| D | GLY283 | |
| E | GLY9 | |
| E | THR43 | |
| E | GLN53 | |
| E | THR182 | |
| E | GLY283 | |
| F | GLY9 | |
| F | THR43 | |
| F | GLN53 | |
| F | THR182 | |
| A | GLN53 | |
| F | GLY283 | |
| G | GLY9 | |
| G | THR43 | |
| G | GLN53 | |
| G | THR182 | |
| G | GLY283 | |
| H | GLY9 | |
| H | THR43 | |
| H | GLN53 | |
| H | THR182 | |
| A | THR182 | |
| H | GLY283 | |
| A | GLY283 | |
| B | GLY9 | |
| B | THR43 | |
| B | GLN53 | |
| B | THR182 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27648606, ECO:0007744|PDB:4YJH |
| Chain | Residue | Details |
| A | VAL10 | |
| B | VAL10 | |
| C | VAL10 | |
| D | VAL10 | |
| E | VAL10 | |
| F | VAL10 | |
| G | VAL10 | |
| H | VAL10 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10876160, ECO:0000269|PubMed:24644036, ECO:0000269|PubMed:27648606, ECO:0000269|PubMed:30333894, ECO:0000269|PubMed:8755502, ECO:0000269|PubMed:9399588, ECO:0007744|PDB:1AN9, ECO:0007744|PDB:1EVI, ECO:0007744|PDB:1KIF, ECO:0007744|PDB:3WGT, ECO:0007744|PDB:4YJD, ECO:0007744|PDB:4YJF, ECO:0007744|PDB:4YJG, ECO:0007744|PDB:4YJH, ECO:0007744|PDB:5WX2 |
| Chain | Residue | Details |
| A | ILE11 | |
| B | ILE11 | |
| C | ILE11 | |
| D | ILE11 | |
| E | ILE11 | |
| F | ILE11 | |
| G | ILE11 | |
| H | ILE11 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10876160, ECO:0000269|PubMed:24644036, ECO:0000269|PubMed:27648606, ECO:0000269|PubMed:30333894, ECO:0000269|PubMed:9153426, ECO:0000269|PubMed:9399588, ECO:0007744|PDB:1AN9, ECO:0007744|PDB:1DDO, ECO:0007744|PDB:1EVI, ECO:0007744|PDB:1KIF, ECO:0007744|PDB:1VE9, ECO:0007744|PDB:3WGT, ECO:0007744|PDB:4YJD, ECO:0007744|PDB:4YJF, ECO:0007744|PDB:4YJG, ECO:0007744|PDB:4YJH, ECO:0007744|PDB:5WWV, ECO:0007744|PDB:5WX2 |
| Chain | Residue | Details |
| A | ARG38 | |
| B | ARG38 | |
| C | ARG38 | |
| D | ARG38 | |
| E | ARG38 | |
| F | ARG38 | |
| G | ARG38 | |
| H | ARG38 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10876160, ECO:0000269|PubMed:24644036, ECO:0000269|PubMed:27648606, ECO:0000269|PubMed:30333894, ECO:0000269|PubMed:8755502, ECO:0000269|PubMed:9153426, ECO:0000269|PubMed:9399588, ECO:0007744|PDB:1AN9, ECO:0007744|PDB:1DDO, ECO:0007744|PDB:1EVI, ECO:0007744|PDB:1KIF, ECO:0007744|PDB:1VE9, ECO:0007744|PDB:3WGT, ECO:0007744|PDB:4YJD, ECO:0007744|PDB:4YJF, ECO:0007744|PDB:4YJG, ECO:0007744|PDB:5WWV |
| Chain | Residue | Details |
| A | THR44 | |
| B | THR44 | |
| C | THR44 | |
| D | THR44 | |
| E | THR44 | |
| F | THR44 | |
| G | THR44 | |
| H | THR44 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10876160, ECO:0000269|PubMed:24644036, ECO:0000269|PubMed:27648606, ECO:0000269|PubMed:8755502, ECO:0000269|PubMed:9399588, ECO:0007744|PDB:1AN9, ECO:0007744|PDB:1EVI, ECO:0007744|PDB:1KIF, ECO:0007744|PDB:1VE9, ECO:0007744|PDB:3WGT, ECO:0007744|PDB:4YJD, ECO:0007744|PDB:4YJF, ECO:0007744|PDB:4YJG, ECO:0007744|PDB:4YJH |
| Chain | Residue | Details |
| A | ALA49 | |
| B | ALA49 | |
| C | ALA49 | |
| D | ALA49 | |
| E | ALA49 | |
| F | ALA49 | |
| G | ALA49 | |
| H | ALA49 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10876160, ECO:0000269|PubMed:24644036, ECO:0000269|PubMed:27648606, ECO:0000269|PubMed:30333894, ECO:0000269|PubMed:8755502, ECO:0000269|PubMed:9153426, ECO:0000269|PubMed:9399588, ECO:0007744|PDB:1AN9, ECO:0007744|PDB:1DDO, ECO:0007744|PDB:1EVI, ECO:0007744|PDB:1KIF, ECO:0007744|PDB:1VE9, ECO:0007744|PDB:3WGT, ECO:0007744|PDB:4YJD, ECO:0007744|PDB:4YJF, ECO:0007744|PDB:4YJG, ECO:0007744|PDB:4YJH, ECO:0007744|PDB:5WWV |
| Chain | Residue | Details |
| A | GLY50 | |
| B | GLY50 | |
| C | GLY50 | |
| D | GLY50 | |
| E | GLY50 | |
| F | GLY50 | |
| G | GLY50 | |
| H | GLY50 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10876160, ECO:0007744|PDB:1EVI |
| Chain | Residue | Details |
| A | LYS163 | |
| B | LYS163 | |
| C | LYS163 | |
| D | LYS163 | |
| E | LYS163 | |
| F | LYS163 | |
| G | LYS163 | |
| H | LYS163 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:9399588, ECO:0007744|PDB:1AN9 |
| Chain | Residue | Details |
| A | TYR224 | |
| E | TYR228 | |
| F | TYR224 | |
| F | TYR228 | |
| G | TYR224 | |
| G | TYR228 | |
| H | TYR224 | |
| H | TYR228 | |
| A | TYR228 | |
| B | TYR224 | |
| B | TYR228 | |
| C | TYR224 | |
| C | TYR228 | |
| D | TYR224 | |
| D | TYR228 | |
| E | TYR224 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10876160, ECO:0000269|PubMed:24644036, ECO:0000269|PubMed:27648606, ECO:0000269|PubMed:9153426, ECO:0007744|PDB:1DDO, ECO:0007744|PDB:1EVI, ECO:0007744|PDB:3WGT, ECO:0007744|PDB:4YJD, ECO:0007744|PDB:4YJF, ECO:0007744|PDB:4YJG, ECO:0007744|PDB:4YJH |
| Chain | Residue | Details |
| A | GLY313 | |
| B | GLY313 | |
| C | GLY313 | |
| D | GLY313 | |
| E | GLY313 | |
| F | GLY313 | |
| G | GLY313 | |
| H | GLY313 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10876160, ECO:0000269|PubMed:24644036, ECO:0000269|PubMed:27648606, ECO:0000269|PubMed:30333894, ECO:0000269|PubMed:8755502, ECO:0000269|PubMed:9153426, ECO:0000269|PubMed:9399588, ECO:0007744|PDB:1AN9, ECO:0007744|PDB:1DDO, ECO:0007744|PDB:1EVI, ECO:0007744|PDB:1KIF, ECO:0007744|PDB:1VE9, ECO:0007744|PDB:3WGT, ECO:0007744|PDB:4YJD, ECO:0007744|PDB:4YJF, ECO:0007744|PDB:4YJG, ECO:0007744|PDB:4YJH, ECO:0007744|PDB:5WX2 |
| Chain | Residue | Details |
| A | LEU316 | |
| B | LEU316 | |
| C | LEU316 | |
| D | LEU316 | |
| E | LEU316 | |
| F | LEU316 | |
| G | LEU316 | |
| H | LEU316 |
