5WWS
Crystal structure of human NSun6/tRNA/SAM
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0001510 | biological_process | RNA methylation |
| A | 0002946 | biological_process | tRNA C5-cytosine methylation |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006400 | biological_process | tRNA modification |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008173 | molecular_function | RNA methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0016428 | molecular_function | tRNA (cytidine-5-)-methyltransferase activity |
| A | 0030488 | biological_process | tRNA methylation |
| A | 0032259 | biological_process | methylation |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0001510 | biological_process | RNA methylation |
| B | 0002946 | biological_process | tRNA C5-cytosine methylation |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006400 | biological_process | tRNA modification |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008173 | molecular_function | RNA methyltransferase activity |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0016428 | molecular_function | tRNA (cytidine-5-)-methyltransferase activity |
| B | 0030488 | biological_process | tRNA methylation |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue SAM A 501 |
| Chain | Residue |
| A | CYS242 |
| A | ASP323 |
| C | C72 |
| A | ALA243 |
| A | ALA244 |
| A | PRO245 |
| A | GLY247 |
| A | LYS248 |
| A | ASP266 |
| A | LYS271 |
| A | GLY294 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue SAM B 501 |
| Chain | Residue |
| B | LEU241 |
| B | CYS242 |
| B | ALA243 |
| B | ALA244 |
| B | PRO245 |
| B | GLY247 |
| B | LYS248 |
| B | ASP266 |
| B | LYS267 |
| B | LYS271 |
| B | ASP293 |
| B | GLY294 |
| B | ASP323 |
| D | C72 |
Functional Information from PROSITE/UniProt
| site_id | PS01153 |
| Number of Residues | 12 |
| Details | NOL1_NOP2_SUN NOL1/NOP2/sun family signature. FDRILlDAPCSG |
| Chain | Residue | Details |
| A | PHE317-GLY328 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01023, ECO:0000269|PubMed:28531330, ECO:0007744|PDB:5WWS |
| Chain | Residue | Details |
| A | CYS373 | |
| B | CYS373 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01023, ECO:0000269|PubMed:28531330, ECO:0007744|PDB:5WWS |
| Chain | Residue | Details |
| A | CYS242 | |
| A | ASP266 | |
| A | ASP323 | |
| B | CYS242 | |
| B | ASP266 | |
| B | ASP323 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01023 |
| Chain | Residue | Details |
| A | ASP293 | |
| B | ASP293 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS419 | |
| B | LYS419 |
