5WRV
Complex structure of human SRP72/SRP68
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005047 | molecular_function | signal recognition particle binding |
| A | 0005786 | cellular_component | signal recognition particle, endoplasmic reticulum targeting |
| A | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
| A | 0008312 | molecular_function | 7S RNA binding |
| A | 0030942 | molecular_function | endoplasmic reticulum signal peptide binding |
| B | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 701 |
| Chain | Residue |
| A | LYS606 |
| B | ASP44 |
| B | VAL45 |
| B | THR46 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 702 |
| Chain | Residue |
| B | HOH319 |
| A | PHE591 |
| A | ASP592 |
| A | LEU593 |
| A | ASN596 |
| B | ASN24 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | ASN77 |
| B | ASN78 |
| B | SER79 |
| B | LEU80 |
| B | SER81 |
| B | ALA104 |
| B | ASN105 |
| B | GLN106 |
| B | HOH316 |
| B | HOH394 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | SER60 |
| B | PHE61 |
| B | LYS62 |
| B | GLU63 |
| B | HOH305 |
| B | HOH374 |
| B | HOH488 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 203 |
| Chain | Residue |
| A | LEU593 |
| B | GLU113 |
| B | GLN117 |
| B | TYR132 |
| B | ASN150 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 204 |
| Chain | Residue |
| A | LEU595 |
| A | HOH806 |
| B | ASN24 |
| B | GLY25 |
| B | GLN57 |
| B | HOH396 |
| B | HOH457 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 205 |
| Chain | Residue |
| B | ILE101 |
| B | GLN107 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 206 |
| Chain | Residue |
| A | ALA599 |
| A | PHE600 |
| A | HOH803 |
| A | HOH807 |
| B | GLY22 |
| B | GLN23 |
| B | PHE27 |
| B | HOH349 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 207 |
| Chain | Residue |
| B | ARG29 |
| B | LYS32 |
| B | ARG121 |
| B | HOH303 |
| B | HOH346 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 208 |
| Chain | Residue |
| B | SER16 |
| B | ASN19 |
| B | ARG20 |
| B | LYS148 |
| B | THR149 |
| B | SER152 |
| B | HOH368 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"Required for interaction with SRP72","evidences":[{"source":"PubMed","id":"16672232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28369529","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
