5WR6

Thermolysin, liganded form with cryo condition 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue NX6 A 401

Chain	Residue
A	ASN112
A	ZN402
A	HOH533
A	HOH576
A	HOH664
A	ALA113
A	HIS142
A	GLU143
A	TYR157
A	GLU166
A	ILE188
A	LEU202
A	HIS231

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 402

Chain	Residue
A	HIS142
A	HIS146
A	GLU166
A	NX6401

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 403

Chain	Residue
A	ASP57
A	ASP59
A	GLN61
A	HOH549
A	HOH584
A	HOH744

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 404

Chain	Residue
A	ASP138
A	GLU177
A	ASP185
A	GLU187
A	GLU190
A	HOH567

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CA A 405

Chain	Residue
A	GLU177
A	ASN183
A	ASP185
A	GLU190
A	HOH602
A	HOH666

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA A 406

Chain	Residue
A	TYR193
A	THR194
A	ILE197
A	ASP200
A	HOH511
A	HOH731

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV

Chain	Residue	Details
A	VAL139-VAL148

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	GLU143

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	HIS231

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP57
A	THR194
A	ILE197
A	ASP200
A	ASP59
A	GLN61
A	ASP138
A	GLU177
A	ASN183
A	ASP185
A	GLU187
A	GLU190

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	HIS142
A	HIS146
A	GLU166

---