5WQD

Crystal structure of TRF2 TRFH in complex with an NBS1 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0005634	cellular_component	nucleus
A	0031848	biological_process	protection from non-homologous end joining at telomere
A	0042162	molecular_function	telomeric DNA binding
A	0042803	molecular_function	protein homodimerization activity
B	0000723	biological_process	telomere maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0005634	cellular_component	nucleus
B	0031848	biological_process	protection from non-homologous end joining at telomere
B	0042162	molecular_function	telomeric DNA binding
B	0042803	molecular_function	protein homodimerization activity
C	0000723	biological_process	telomere maintenance
C	0000781	cellular_component	chromosome, telomeric region
C	0005634	cellular_component	nucleus
C	0031848	biological_process	protection from non-homologous end joining at telomere
C	0042162	molecular_function	telomeric DNA binding
C	0042803	molecular_function	protein homodimerization activity
D	0000723	biological_process	telomere maintenance
D	0000781	cellular_component	chromosome, telomeric region
D	0005634	cellular_component	nucleus
D	0031848	biological_process	protection from non-homologous end joining at telomere
D	0042162	molecular_function	telomeric DNA binding
D	0042803	molecular_function	protein homodimerization activity
E	0000723	biological_process	telomere maintenance
E	0000781	cellular_component	chromosome, telomeric region
E	0005634	cellular_component	nucleus
E	0031848	biological_process	protection from non-homologous end joining at telomere
E	0042162	molecular_function	telomeric DNA binding
E	0042803	molecular_function	protein homodimerization activity
F	0000723	biological_process	telomere maintenance
F	0000781	cellular_component	chromosome, telomeric region
F	0005634	cellular_component	nucleus
F	0031848	biological_process	protection from non-homologous end joining at telomere
F	0042162	molecular_function	telomeric DNA binding
F	0042803	molecular_function	protein homodimerization activity
G	0000723	biological_process	telomere maintenance
G	0000781	cellular_component	chromosome, telomeric region
G	0005634	cellular_component	nucleus
G	0031848	biological_process	protection from non-homologous end joining at telomere
G	0042162	molecular_function	telomeric DNA binding
G	0042803	molecular_function	protein homodimerization activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Modified residue: {"description":"Phosphothreonine; by ATM","evidences":[{"source":"PubMed","id":"16223874","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	203
Details	Region: {"description":"TRFH dimerization"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"Phosphoserine; by CDK2","evidences":[{"source":"PubMed","id":"28216226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	14
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23115235","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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