5WQC
Crystal structure of human orexin 2 receptor bound to the selective antagonist EMPA determined by the synchrotron light source at SPring-8.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 7MA A 2001 |
| Chain | Residue |
| A | PRO131 |
| A | VAL353 |
| A | TYR354 |
| A | HOH4022 |
| A | HOH4031 |
| A | HOH4092 |
| A | GLN187 |
| A | HIS224 |
| A | PHE227 |
| A | TYR317 |
| A | ILE320 |
| A | SER321 |
| A | ASN324 |
| A | HIS350 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue OLA A 3001 |
| Chain | Residue |
| A | PHE366 |
| A | OLA3003 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue OLA A 3002 |
| Chain | Residue |
| A | LEU150 |
| A | LEU229 |
| A | VAL230 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue OLA A 3003 |
| Chain | Residue |
| A | ILE315 |
| A | CYS316 |
| A | ALA355 |
| A | OLA3001 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue OLA A 3004 |
| Chain | Residue |
| A | GLU52 |
| A | TYR53 |
| A | VAL56 |
| A | LEU57 |
| A | GLY60 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue OLA A 3005 |
| Chain | Residue |
| A | TYR219 |
| A | ASN365 |
| A | PHE366 |
| A | ARG372 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE A 3501 |
| Chain | Residue |
| A | ASP211 |
| A | LYS327 |
| A | PHE346 |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSVlTLSCIALDRWYaI |
| Chain | Residue | Details |
| A | VAL140-ILE156 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 31 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 31 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31860301","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4S0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6TPJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for responses to orexin","evidences":[{"source":"PubMed","id":"26950369","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
