5WP4
Arabidopsis thaliana phosphoethanolamine N-methyltransferase 1 (AtPMT1, XIOPTL) in complex with SAH and phosphocholine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000234 | molecular_function | phosphoethanolamine N-methyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0009555 | biological_process | pollen development |
| A | 0009826 | biological_process | unidimensional cell growth |
| A | 0009860 | biological_process | pollen tube growth |
| A | 0010183 | biological_process | pollen tube guidance |
| A | 0032259 | biological_process | methylation |
| A | 0042425 | biological_process | choline biosynthetic process |
| A | 0048528 | biological_process | post-embryonic root development |
| A | 0052667 | molecular_function | phosphomethylethanolamine N-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue SAH A 701 |
| Chain | Residue |
| A | ARG9 |
| A | ILE84 |
| A | ALA106 |
| A | ASP107 |
| A | VAL108 |
| A | ASN126 |
| A | TRP127 |
| A | PC704 |
| A | HOH834 |
| A | HOH900 |
| A | HOH923 |
| A | TRP16 |
| A | HOH932 |
| A | HOH984 |
| A | HOH991 |
| A | MET28 |
| A | GLY61 |
| A | GLY63 |
| A | ARG66 |
| A | PHE67 |
| A | ASP82 |
| A | PHE83 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue PC A 702 |
| Chain | Residue |
| A | GLN245 |
| A | TYR246 |
| A | TYR254 |
| A | VAL263 |
| A | ASP356 |
| A | TYR386 |
| A | TYR400 |
| A | ARG404 |
| A | TYR406 |
| A | LYS472 |
| A | SAH703 |
| A | HOH965 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue SAH A 703 |
| Chain | Residue |
| A | LEU241 |
| A | TYR246 |
| A | PHE262 |
| A | VAL263 |
| A | SER264 |
| A | GLY290 |
| A | ASP312 |
| A | LEU313 |
| A | SER314 |
| A | MET317 |
| A | ALA337 |
| A | ASP338 |
| A | CYS339 |
| A | ARG355 |
| A | ASP356 |
| A | THR357 |
| A | HIS360 |
| A | ILE361 |
| A | PC702 |
| A | HOH868 |
| A | HOH933 |
| A | HOH983 |
| A | HOH1029 |
| A | HOH1195 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue PC A 704 |
| Chain | Residue |
| A | MET28 |
| A | MET29 |
| A | LEU30 |
| A | TRP127 |
| A | MET130 |
| A | TYR131 |
| A | SER159 |
| A | GLN163 |
| A | SER164 |
| A | GLY165 |
| A | ARG169 |
| A | TYR176 |
| A | SAH701 |
| A | HOH866 |
| A | HOH905 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29084845, ECO:0007744|PDB:5WP4 |
| Chain | Residue | Details |
| A | TYR254 | |
| A | VAL263 | |
| A | SER264 | |
| A | GLY290 | |
| A | ASP312 | |
| A | ASP338 | |
| A | CYS339 | |
| A | TYR386 | |
| A | TYR400 | |
| A | ARG404 | |
| A | TYR406 | |
| A | LYS472 | |
| A | ARG66 | |
| A | ASP82 | |
| A | ASP107 | |
| A | VAL108 | |
| A | ASN126 | |
| A | SER159 | |
| A | SER164 | |
| A | GLY165 | |
| A | ARG169 | |
| A | TYR176 | |
| A | GLY61 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q22993 |
| Chain | Residue | Details |
| A | ARG355 | |
| A | GLN245 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | ALA2 |
