5WMG
N-terminal bromodomain of BRD4 in complex with OTX-015
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 201 |
| Chain | Residue |
| A | 6JF204 |
| A | HOH302 |
| A | HOH308 |
| A | HOH344 |
| A | HOH398 |
| A | HOH512 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 202 |
| Chain | Residue |
| A | ALA122 |
| A | GLU167 |
| A | HOH362 |
| A | HOH382 |
| A | HOH409 |
| A | HOH426 |
| A | GLU49 |
| A | GLN62 |
| A | ASN121 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 203 |
| Chain | Residue |
| A | ILE100 |
| A | ILE101 |
| A | LYS102 |
| A | THR103 |
| A | ASN135 |
| A | ASP145 |
| A | HOH301 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue 6JF A 204 |
| Chain | Residue |
| A | TRP81 |
| A | PRO82 |
| A | PHE83 |
| A | GLN85 |
| A | LYS91 |
| A | LEU92 |
| A | ASN140 |
| A | ASP145 |
| A | MET149 |
| A | EDO201 |
| A | HOH310 |
| A | HOH314 |
| A | HOH316 |
| A | HOH321 |
| A | HOH420 |
| A | HOH529 |
| A | HOH564 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
