5WM8

Structure of the 10R (+)-cis-BP-dG modified Rev1 ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG P 101

Chain	Residue
A	ASP548
A	LEU550
A	VAL553
A	HOH1125
P	DA11
P	HOH209

---

site_id	AC2
Number of Residues	8
Details	binding site for residue BAP T 101

Chain	Residue
A	EDO811
A	PEG817
A	HOH978
A	HOH1008
T	DG5
A	ASP399
A	TRP417
A	LYS681

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 801

Chain	Residue
A	ASP362
A	ASP467
A	GLU468
A	MG802
A	DCP804
P	DDG12

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 802

Chain	Residue
A	ASP362
A	PHE363
A	ASP467
A	MG801
A	MG803
A	DCP804

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 803

Chain	Residue
A	ASP362
A	MG802
A	DCP804
A	HOH1019
A	HOH1091
A	HOH1097

---

site_id	AC6
Number of Residues	26
Details	binding site for residue DCP A 804

Chain	Residue
A	ARG324
A	LEU328
A	ASP362
A	PHE363
A	ASP364
A	CYS365
A	PHE366
A	PHE367
A	ALA401
A	SER402
A	TYR405
A	ARG408
A	ASN414
A	ASP467
A	LYS525
A	MG801
A	MG802
A	MG803
A	GOL807
A	HOH942
A	HOH948
A	HOH1001
A	HOH1049
A	HOH1050
A	HOH1097
P	DDG12

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 805

Chain	Residue
A	TRP331
A	ASN334
A	LEU335
A	GLN442
A	SER445

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL A 806

Chain	Residue
A	LEU335
A	LYS338
A	TYR449
A	ILE461
A	HOH1022

---

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL A 807

Chain	Residue
A	ARG324
A	GLY415
A	DCP804
A	HOH902
A	HOH913
P	DDG12

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 808

Chain	Residue
A	VAL308
A	SER318
A	TYR319
T	DC4

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 809

Chain	Residue
A	ARG488
A	PHE691
A	SER692
A	LEU718
A	HOH1145

---

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO A 810

Chain	Residue
A	ASN527
A	HOH984

---

site_id	AD4
Number of Residues	4
Details	binding site for residue EDO A 811

Chain	Residue
A	MET416
A	TRP417
A	GLN420
T	BAP101

---

site_id	AD5
Number of Residues	8
Details	binding site for residue EDO A 812

Chain	Residue
A	CYS365
A	PHE384
A	LYS385
A	PRO526
A	HOH932
A	HOH988
A	HOH1034
A	HOH1065

---

site_id	AD6
Number of Residues	7
Details	binding site for residue EDO A 813

Chain	Residue
A	TYR649
A	HOH930
A	HOH1144
T	DT7
T	DA8
A	HIS326
A	SER624

---

site_id	AD7
Number of Residues	7
Details	binding site for residue EDO A 814

Chain	Residue
A	SER378
A	PHE379
A	SER380
A	ALA381
A	CYS382
A	GLU678
A	PRO679

---

site_id	AD8
Number of Residues	7
Details	binding site for residue EDO A 815

Chain	Residue
A	SER622
A	GLN731
A	ASN733
A	HOH991
T	DC9
T	HOH201
T	HOH211

---

site_id	AD9
Number of Residues	1
Details	binding site for residue EDO A 816

Chain	Residue
A	ASP352

---

site_id	AE1
Number of Residues	5
Details	binding site for residue PEG A 817

Chain	Residue
A	HOH978
A	HOH998
A	HOH1102
A	HOH1121
T	BAP101

---

site_id	AE2
Number of Residues	2
Details	binding site for residue PEG A 818

Chain	Residue
A	GLN499
A	ASN502

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	196
Details	Domain: {"description":"UmuC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	23
Details	Region: {"description":"Interaction with target DNA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195463","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18275815","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18275815","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Site: {"description":"Interaction with target DNA"}

Chain

Residue

Details

---