5WM0

Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked with peptide (peptide not observed)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004497	molecular_function	monooxygenase activity
A	0005507	molecular_function	copper ion binding
A	0006518	biological_process	peptide metabolic process
A	0016020	cellular_component	membrane
A	0016715	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10504734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15131304","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16100265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20958070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23247335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36880254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PHM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DSJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10504734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15131304","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16100265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20958070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23247335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30271955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36880254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PHM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ALV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DSJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10504734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15131304","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20958070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23247335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30271955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36880254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PHM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ALV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DSJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 135

Chain	Residue	Details
A	HIS107	metal ligand
A	HIS108	hydrogen bond donor, metal ligand, single electron acceptor, single electron donor, single electron relay
A	GLN170	hydrogen bond acceptor, single electron acceptor, single electron donor, single electron relay
A	HIS172	metal ligand
A	HIS242	metal ligand
A	HIS244	metal ligand
A	MET314	metal ligand

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