5WKL

1.85 A resolution structure of MERS 3CL protease in complex with piperidine-based peptidomimetic inhibitor 17

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0019082	biological_process	viral protein processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue AVY A 401

Chain	Residue
A	HIS41
A	GLU169
A	HIS175
A	ASP190
A	GLN192
A	B3J402
A	HOH564
A	THR62
A	HIS64
A	PHE143
A	CYS145
A	CYS148
A	HIS166
A	GLN167
A	MET168

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site_id	AC2
Number of Residues	16
Details	binding site for residue B3J A 402

Chain	Residue
A	THR62
A	HIS64
A	PHE143
A	CYS145
A	GLY146
A	SER147
A	CYS148
A	HIS166
A	GLN167
A	MET168
A	GLU169
A	HIS175
A	ASP190
A	GLN192
A	AVY401
A	HOH564

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772

Chain	Residue	Details
A	HIS41
A	CYS148

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000250

Chain	Residue	Details
A	GLN306

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