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5WK3

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CCL17 AND M116 FAB

Functional Information from GO Data
ChainGOidnamespacecontents
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007267biological_processcell-cell signaling
A0008009molecular_functionchemokine activity
A0030335biological_processpositive regulation of cell migration
A0048020molecular_functionCCR chemokine receptor binding
A0060326biological_processcell chemotaxis
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
B0005102molecular_functionsignaling receptor binding
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007267biological_processcell-cell signaling
B0008009molecular_functionchemokine activity
B0030335biological_processpositive regulation of cell migration
B0048020molecular_functionCCR chemokine receptor binding
B0060326biological_processcell chemotaxis
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0070098biological_processchemokine-mediated signaling pathway
C0005102molecular_functionsignaling receptor binding
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006935biological_processchemotaxis
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007267biological_processcell-cell signaling
C0008009molecular_functionchemokine activity
C0030335biological_processpositive regulation of cell migration
C0048020molecular_functionCCR chemokine receptor binding
C0060326biological_processcell chemotaxis
C0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
C0070098biological_processchemokine-mediated signaling pathway
D0005102molecular_functionsignaling receptor binding
D0005125molecular_functioncytokine activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006935biological_processchemotaxis
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0007267biological_processcell-cell signaling
D0008009molecular_functionchemokine activity
D0030335biological_processpositive regulation of cell migration
D0048020molecular_functionCCR chemokine receptor binding
D0060326biological_processcell chemotaxis
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0070098biological_processchemokine-mediated signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue GOL Q 301
ChainResidue
PTYR55
PGLU61
QPRO101
QASP106
QSER107
QASP109

site_idAC2
Number of Residues10
Detailsbinding site for residue GOL S 301
ChainResidue
RTHR184
SPHE174
SPRO175
SVAL177
SSER185
SLEU186
SSER187
RGLN166
RSER168
RSER182

site_idAC3
Number of Residues5
Detailsbinding site for residue GOL U 301
ChainResidue
TTYR55
UPRO101
UASP106
USER107
UHOH403

site_idAC4
Number of Residues11
Detailsbinding site for residue GOL V 1001
ChainResidue
VGLN166
VSER182
VSER183
VTHR184
VHOH1105
WPHE174
WPRO175
WVAL177
WSER185
WLEU186
WSER187

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
PTYR198-HIS204
QTYR202-HIS208

site_idPS00472
Number of Residues42
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLeyfkga..IplrkLktWyqtsed..Csrd.AIVFvtvqgrai.CS
ChainResidueDetails
ACYS10-SER51

224004

PDB entries from 2024-08-21

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