5WJ1

Crystal structure of Arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0003984	molecular_function	acetolactate synthase activity
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0030976	molecular_function	thiamine pyrophosphate binding
A	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 701

Chain	Residue
A	ASP538
A	ASN565
A	HIS567
A	TP9706
A	HOH945

---

site_id	AC2
Number of Residues	38
Details	binding site for residue FAD A 702

Chain	Residue
A	GLY309
A	THR331
A	LEU332
A	MET333
A	MET348
A	LEU349
A	GLY350
A	MET351
A	HIS352
A	GLY371
A	VAL372
A	ARG373
A	ARG377
A	VAL378
A	ASP395
A	ILE396
A	ASP397
A	GLU400
A	GLY413
A	ASP414
A	VAL415
A	GLN489
A	MET490
A	GLY508
A	GLY509
A	MET570
A	PXD704
A	HOH801
A	HOH854
A	HOH860
A	HOH864
A	HOH867
A	HOH884
A	HOH1118
A	PHE206
A	ARG246
A	GLY307
A	GLY308

---

site_id	AC3
Number of Residues	4
Details	binding site for residue K A 703

Chain	Residue
A	MET543
A	MET543
A	GLN546
A	GLN546

---

site_id	AC4
Number of Residues	25
Details	binding site for residue PXD A 704

Chain	Residue
A	GLY121
A	ALA122
A	MET124
A	SER168
A	VAL196
A	ARG199
A	MET200
A	PHE206
A	LYS256
A	MET351
A	ASP376
A	ARG377
A	MET570
A	VAL571
A	TRP574
A	SER653
A	GLY654
A	FAD702
A	F50705
A	HOH827
A	HOH1113
A	HOH1178
A	HOH1261
A	HOH1361
A	HOH1387

---

site_id	AC5
Number of Residues	6
Details	binding site for residue F50 A 705

Chain	Residue
A	GLY120
A	GLY121
A	GLN207
A	MET570
A	PXD704
A	TP9706

---

site_id	AC6
Number of Residues	26
Details	binding site for residue TP9 A 706

Chain	Residue
A	VAL571
A	MG701
A	F50705
A	HOH844
A	HOH945
A	PRO119
A	GLY120
A	GLU144
A	PRO170
A	ASN174
A	GLN207
A	VAL485
A	GLY486
A	GLN487
A	HIS488
A	GLY511
A	MET513
A	GLY537
A	ASP538
A	GLY539
A	SER540
A	ASN565
A	HIS567
A	LEU568
A	GLY569
A	MET570

---

Functional Information from PROSITE/UniProt

site_id	PS00187
Number of Residues	20
Details	TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGasvanPdaivVdIdGDGS

Chain	Residue	Details
A	ILE521-SER540

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z8N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YBH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZ8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32640464","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VZ8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Cysteine sulfinic acid (-SO2H)","evidences":[{"source":"PubMed","id":"16407096","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187232","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---