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5WIY

Kelch domain of human Keap1 bound to small molecule inhibitor fragment: 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione

Functional Information from GO Data
ChainGOidnamespacecontents
A0008134molecular_functiontranscription factor binding
A0016567biological_processprotein ubiquitination
A0031463cellular_componentCul3-RING ubiquitin ligase complex
B0008134molecular_functiontranscription factor binding
B0016567biological_processprotein ubiquitination
B0031463cellular_componentCul3-RING ubiquitin ligase complex
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue SO4 A 701
ChainResidue
AGLN337
APRO384
AHOH801
BARG380
BASN382
BASN414
BARG415

site_idAC2
Number of Residues4
Detailsbinding site for residue SO4 A 702
ChainResidue
AASN414
AARG415
AARG380
AASN382

site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 A 703
ChainResidue
AHIS437
AASN438
ASER439
AARG459

site_idAC4
Number of Residues5
Detailsbinding site for residue 1XM A 704
ChainResidue
AARG483
ASER508
ATYR525
AGLN530
ASER555

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Sensor for electrophilic agents => ECO:0000250|UniProtKB:Q9Z2X8
ChainResidueDetails
ACYS434
BCYS434

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: S-(2-succinyl)cysteine => ECO:0000250|UniProtKB:Q9Z2X8
ChainResidueDetails
ASER319
ASER613
BSER319
BSER613

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: S-cGMP-cysteine => ECO:0000250|UniProtKB:Q9Z2X8
ChainResidueDetails
ACYS434
BCYS434

226707

PDB entries from 2024-10-30

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