5WHB

KRas G12V, bound to GDP and miniprotein 225-11(A30R)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
J	0003924	molecular_function	GTPase activity
J	0005525	molecular_function	GTP binding
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue GDP A 201

Chain	Residue
A	GLY13
A	ASP119
A	LEU120
A	SER145
A	ALA146
A	LYS147
A	MG202
A	VAL14
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	ASN116
A	LYS117

---

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 202

Chain	Residue
A	SER17
A	GDP201

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CA A 203

Chain	Residue
A	GLU63
B	ALA32
L	ASP16

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CA A 204

Chain	Residue
A	GLU63
A	TYR64
B	HOH101
L	ASP16
L	GLU19

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CA C 101

Chain	Residue
C	ASP16
C	HOH205
J	GLU63
K	ALA32

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CA C 102

Chain	Residue
C	ASP16
C	GLU19
J	GLU63
J	TYR64

---

site_id	AC7
Number of Residues	17
Details	binding site for residue GDP D 201

Chain	Residue
D	VAL12
D	GLY13
D	VAL14
D	GLY15
D	LYS16
D	SER17
D	ALA18
D	ASN116
D	LYS117
D	ASP119
D	LEU120
D	SER145
D	ALA146
D	LYS147
D	MG202
D	HOH301
D	HOH310

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG D 202

Chain	Residue
D	SER17
D	GDP201
D	HOH301
D	HOH310

---

site_id	AC9
Number of Residues	3
Details	binding site for residue CA D 203

Chain	Residue
D	GLU63
E	ALA32
I	ASP16

---

site_id	AD1
Number of Residues	6
Details	binding site for residue CA D 204

Chain	Residue
D	GLU63
D	TYR64
D	HOH318
E	HOH109
I	ASP16
I	GLU19

---

site_id	AD2
Number of Residues	6
Details	binding site for residue CA F 101

Chain	Residue
F	ASP16
F	GLU19
F	HOH203
G	GLU63
G	TYR64
G	HOH330

---

site_id	AD3
Number of Residues	3
Details	binding site for residue CA F 102

Chain	Residue
F	ASP16
G	GLU63
H	ALA32

---

site_id	AD4
Number of Residues	19
Details	binding site for residue GDP G 201

Chain	Residue
G	VAL12
G	GLY13
G	VAL14
G	GLY15
G	LYS16
G	SER17
G	ALA18
G	PHE28
G	ASN116
G	LYS117
G	ASP119
G	LEU120
G	SER145
G	ALA146
G	LYS147
G	MG202
G	HOH304
G	HOH315
G	HOH320

---

site_id	AD5
Number of Residues	4
Details	binding site for residue MG G 202

Chain	Residue
G	SER17
G	ASP57
G	GDP201
G	HOH315

---

site_id	AD6
Number of Residues	14
Details	binding site for residue GDP J 201

Chain	Residue
J	SER17
J	ALA18
J	ASN116
J	LYS117
J	ASP119
J	LEU120
J	SER145
J	ALA146
J	LYS147
J	MG202
J	VAL12
J	GLY13
J	GLY15
J	LYS16

---

site_id	AD7
Number of Residues	4
Details	binding site for residue MG J 202

Chain	Residue
J	SER17
J	GDP201
J	HOH319
J	HOH328

---

site_id	AD8
Number of Residues	2
Details	binding site for residue CA J 203

Chain	Residue
J	LYS5
L	TRP25

---

site_id	AD9
Number of Residues	4
Details	binding site for residue CA J 204

Chain	Residue
J	GLU3
J	ASP54
K	HIS18
K	TRP21

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---