5WGI

Ultrahigh resolution crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with TSA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0004407	molecular_function	histone deacetylase activity
A	0006325	biological_process	chromatin organization
A	0016575	biological_process	histone deacetylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 801

Chain	Residue
A	ASP612
A	HIS614
A	ASP705
A	TSN802

---

site_id	AC2
Number of Residues	15
Details	binding site for residue TSN A 802

Chain	Residue
A	PHE583
A	ASP612
A	HIS614
A	PHE643
A	ASP705
A	LEU712
A	GLY743
A	TYR745
A	ZN801
A	HOH921
A	HIS463
A	PRO464
A	HIS573
A	HIS574
A	GLY582

---

site_id	AC3
Number of Residues	5
Details	binding site for residue K A 803

Chain	Residue
A	ASP610
A	ASP612
A	HIS614
A	SER633
A	LEU634

---

site_id	AC4
Number of Residues	6
Details	binding site for residue K A 804

Chain	Residue
A	PHE623
A	ASP626
A	VAL629
A	TYR662
A	HOH1036
A	HOH1061

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 805

Chain	Residue
A	ARG451
A	THR540

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CL A 806

Chain	Residue
A	ARG481
A	LEU483
A	SER484
A	HOH1279

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CL A 807

Chain	Residue
A	PRO519
A	ARG520
A	HOH1018
A	HOH1211

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 808

Chain	Residue
A	TYR529
A	SER531
A	HOH928
A	HOH941
A	HOH1123

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 809

Chain	Residue
A	ASP521
A	ARG524
A	LEU525
A	GLU528
A	HOH1196

---

site_id	AD1
Number of Residues	8
Details	binding site for residue EDO A 810

Chain	Residue
A	ASN457
A	SER461
A	LEU466
A	ARG660
A	HOH905
A	HOH1074
A	HOH1162
A	HOH1247

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 811

Chain	Residue
A	ILE622
A	HOH908
A	HOH931
A	HOH938
A	HOH1082

---

site_id	AD3
Number of Residues	9
Details	binding site for residue EDO A 812

Chain	Residue
A	ASN436
A	ALA500
A	HIS503
A	SER504
A	SER505
A	ILE508
A	HOH1097
A	HOH1163
A	HOH1273

---

site_id	AD4
Number of Residues	8
Details	binding site for residue EDO A 813

Chain	Residue
A	ARG594
A	GLN597
A	GLU602
A	MG822
A	HOH906
A	HOH912
A	HOH966
A	HOH1012

---

site_id	AD5
Number of Residues	7
Details	binding site for residue EDO A 814

Chain	Residue
A	ARG492
A	THR495
A	GLU498
A	HOH903
A	HOH944
A	HOH1016
A	HOH1050

---

site_id	AD6
Number of Residues	1
Details	binding site for residue EDO A 815

Chain	Residue
A	HOH944

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO A 816

Chain	Residue
A	THR558
A	GLY559
A	HOH1022

---

site_id	AD8
Number of Residues	7
Details	binding site for residue GOL A 817

Chain	Residue
A	ARG472
A	THR748
A	ALA791
A	PRO792
A	ARG798
A	HOH993
A	HOH1039

---

site_id	AD9
Number of Residues	9
Details	binding site for residue GOL A 818

Chain	Residue
A	SER475
A	PRO792
A	PHE793
A	SER795
A	ARG798
A	GOL819
A	HOH1209
A	HOH1253
A	SER471

---

site_id	AE1
Number of Residues	5
Details	binding site for residue GOL A 819

Chain	Residue
A	ARG660
A	TYR662
A	PHE793
A	TRP794
A	GOL818

---

site_id	AE2
Number of Residues	5
Details	binding site for residue PEG A 820

Chain	Residue
A	TRP459
A	PRO519
A	ASN523
A	HIS683
A	HOH1111

---

site_id	AE3
Number of Residues	6
Details	binding site for residue PEG A 821

Chain	Residue
A	ASN457
A	HIS463
A	SER531
A	ILE532
A	PHE583
A	HOH928

---

site_id	AE4
Number of Residues	7
Details	binding site for residue MG A 822

Chain	Residue
A	EDO813
A	HOH906
A	HOH966
A	HOH1012
A	HOH1041
A	HOH1216
A	HOH1298

---