5WFI

X-ray structure of MHV PLP2 (Cys1716Ser) catalytic mutant in complex with free ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 2001

Chain	Residue
A	PHE1641
A	ASP1643
A	GLY1644
A	PHE1662
A	TYR1689

---

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 2002

Chain	Residue
B	ARG1651
A	ARG1623
A	SER1665
A	ASP1666
A	ASP1671

---

site_id	AC3
Number of Residues	8
Details	binding site for residue GOL A 2003

Chain	Residue
A	ARG1822
A	HIS1836
B	VAL1793
B	CYS1794
B	ASN1825
B	SER1832
B	LYS1833
B	LEU1834

---

site_id	AC4
Number of Residues	6
Details	binding site for residue FMT A 2004

Chain	Residue
A	ARG1779
A	GLU1780
A	ALA1781
A	HOH2136
A	HOH2165
A	HOH2206

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 2005

Chain	Residue
A	CYS1794
A	CYS1796
A	CYS1828
A	CYS1830

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL B 2001

Chain	Residue
B	ARG1623
B	SER1665
B	ASP1666
B	LEU1667
B	SER1668
B	ASP1671
B	HOH2144

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL B 2002

Chain	Residue
B	PHE1662
B	TYR1689
B	TYR1690
B	GLN1736
B	HOH2134

---

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL B 2003

Chain	Residue
A	GLY1658
A	HOH2101
B	HOH2122
B	HOH2196

---

site_id	AC9
Number of Residues	4
Details	binding site for residue FMT B 2004

Chain	Residue
A	ARG1623
A	THR1636
A	GLN1663
B	ARG1651

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 2005

Chain	Residue
B	CYS1794
B	CYS1796
B	CYS1828
B	CYS1830

---

site_id	AD2
Number of Residues	9
Details	binding site for residue GOL C 101

Chain	Residue
A	ASP1772
C	LYS27
C	ARG42
C	LEU43
C	GLN49
C	LEU50
C	ARG72
C	HOH202
C	HOH207

---

site_id	AD3
Number of Residues	6
Details	binding site for residue GOL C 102

Chain	Residue
C	THR7
C	LEU8
C	THR9
C	ILE36
C	LEU69
C	HOH227

---

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL D 101

Chain	Residue
D	THR7
D	LEU8
D	ILE36
D	LEU69
D	HOH214
D	HOH229
D	HOH244

---

site_id	AD5
Number of Residues	10
Details	binding site for residue GOL D 102

Chain	Residue
B	ASP1772
D	LYS27
D	ARG42
D	LEU43
D	GLN49
D	LEU50
D	GLU51
D	ARG72
D	HOH213
D	HOH269

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
C	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Zinc finger: {"description":"C4-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"For PL2-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	150
Details	Domain: {"description":"Ubiquitin-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---