Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5WEH

Cytochrome c oxidase from Rhodobacter sphaeroides in the reduced state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006119	biological_process	oxidative phosphorylation
A	0009060	biological_process	aerobic respiration
A	0015990	biological_process	electron transport coupled proton transport
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0045277	cellular_component	respiratory chain complex IV
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022900	biological_process	electron transport chain
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005886	cellular_component	plasma membrane
C	0009055	molecular_function	electron transfer activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0019646	biological_process	aerobic electron transport chain
C	0022904	biological_process	respiratory electron transport chain
C	1902600	biological_process	proton transmembrane transport
G	0004129	molecular_function	cytochrome-c oxidase activity
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0006119	biological_process	oxidative phosphorylation
G	0009060	biological_process	aerobic respiration
G	0015990	biological_process	electron transport coupled proton transport
G	0016020	cellular_component	membrane
G	0020037	molecular_function	heme binding
G	0022904	biological_process	respiratory electron transport chain
G	0045277	cellular_component	respiratory chain complex IV
G	0046872	molecular_function	metal ion binding
G	1902600	biological_process	proton transmembrane transport
H	0004129	molecular_function	cytochrome-c oxidase activity
H	0005507	molecular_function	copper ion binding
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0022900	biological_process	electron transport chain
H	0042773	biological_process	ATP synthesis coupled electron transport
H	0046872	molecular_function	metal ion binding
H	1902600	biological_process	proton transmembrane transport
I	0004129	molecular_function	cytochrome-c oxidase activity
I	0005886	cellular_component	plasma membrane
I	0009055	molecular_function	electron transfer activity
I	0009060	biological_process	aerobic respiration
I	0016020	cellular_component	membrane
I	0019646	biological_process	aerobic electron transport chain
I	0022904	biological_process	respiratory electron transport chain
I	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue HEA A 601

Chain	Residue
A	LEU34
A	HIS102
A	GLY103
A	MET106
A	MET107
A	VAL111
A	GLY171
A	TRP172
A	TYR414
A	PHE420
A	HIS421
A	GLY37
A	MET424
A	SER425
A	VAL429
A	PHE468
A	GLN471
A	ARG481
A	ARG482
A	ALA501
A	PHE508
A	GLY38
A	VAL45
A	THR48
A	MET51
A	ARG52
A	TRP95
A	ILE99

site_id	AC2
Number of Residues	24
Details	binding site for residue HEA A 602

Chain	Residue
A	TRP172
A	VAL287
A	VAL291
A	HIS333
A	ALA356
A	GLY360
A	ILE363
A	PHE391
A	THR392
A	GLY395
A	GLY398
A	LEU401
A	SER402
A	ASP407
A	HIS411
A	VAL416
A	HIS419
A	PHE420
A	VAL423
A	MET424
A	ARG481
A	HOH701
B	PRO108
B	ILE111

site_id	AC3
Number of Residues	3
Details	binding site for residue CU1 A 603

Chain	Residue
A	HIS284
A	HIS333
A	HIS334

site_id	AC4
Number of Residues	4
Details	binding site for residue MG A 604

Chain	Residue
A	HIS411
A	ASP412
B	ASP229
B	GLU254

site_id	AC5
Number of Residues	4
Details	binding site for residue CA A 605

Chain	Residue
A	GLU54
A	ALA57
A	GLY59
A	GLN61

site_id	AC6
Number of Residues	13
Details	binding site for residue 3PE A 606

Chain	Residue
A	PHE135
A	PRO136
A	ARG137
A	MET138
C	HIS10
C	LEU12
C	TRP58
C	TRP59
C	VAL62
C	GLU65
C	HIS71
C	GLY82
C	3PE301

site_id	AC7
Number of Residues	13
Details	binding site for residue 3PE A 607

Chain	Residue
A	ARG216
A	THR221
A	MET222
A	HIS223
A	TRP230
A	TRP237
A	VAL321
C	MET88
C	3PE302
D	GLN20
D	THR24
D	MET31
D	3PE101

site_id	AC8
Number of Residues	3
Details	binding site for residue LMU G 601

Chain	Residue
A	TRP451
A	TYR517
G	GLU69

site_id	AC9
Number of Residues	23
Details	binding site for residue HEA G 602

Chain	Residue
G	MET106
G	MET107
G	VAL111
G	GLY171
G	TRP172
G	TYR414
G	HIS421
G	MET424
G	SER425
G	VAL429
G	ILE432
G	MET460
G	PHE468
G	GLN471
G	ARG481
G	ARG482
G	GLY38
G	VAL45
G	THR48
G	MET51
G	ARG52
G	ILE99
G	HIS102

site_id	AD1
Number of Residues	24
Details	binding site for residue HEA G 603

Chain	Residue
G	TRP172
G	TRP280
G	VAL287
G	VAL291
G	HIS333
G	THR352
G	ILE355
G	THR359
G	GLY360
G	PHE391
G	GLY395
G	GLY398
G	ILE399
G	LEU401
G	SER402
G	ASP407
G	HIS411
G	VAL416
G	HIS419
G	PHE420
G	VAL423
G	MET424
G	ARG481
H	PRO108

site_id	AD2
Number of Residues	3
Details	binding site for residue CU1 G 604

Chain	Residue
G	HIS284
G	HIS333
G	HIS334

site_id	AD3
Number of Residues	4
Details	binding site for residue MG G 605

Chain	Residue
G	HIS411
G	ASP412
H	ASP229
H	GLU254

site_id	AD4
Number of Residues	5
Details	binding site for residue CA G 606

Chain	Residue
G	GLU54
G	ALA57
G	PRO58
G	GLY59
G	GLN61

site_id	AD5
Number of Residues	11
Details	binding site for residue 3PE G 607

Chain	Residue
G	PHE135
G	PRO136
G	ARG137
G	MET138
G	LEU196
I	HIS10
I	TRP58
I	TRP59
I	GLU65
I	HIS71
I	GLY82

site_id	AD6
Number of Residues	8
Details	binding site for residue 3PE G 608

Chain	Residue
G	ARG216
G	THR221
G	MET222
G	HIS223
G	TRP237
G	VAL321
J	GLN20
J	THR24

site_id	AD7
Number of Residues	2
Details	binding site for residue LMU G 609

Chain	Residue
G	TRP451
G	TYR517

site_id	AD8
Number of Residues	5
Details	binding site for residue CU1 B 301

Chain	Residue
B	CYS252
B	GLU254
B	CYS256
B	HIS260
B	CU1302

site_id	AD9
Number of Residues	5
Details	binding site for residue CU1 B 302

Chain	Residue
B	HIS217
B	CYS252
B	CYS256
B	MET263
B	CU1301

site_id	AE1
Number of Residues	13
Details	binding site for residue 3PE C 301

Chain	Residue
A	3PE606
C	TRP59
C	VAL62
C	SER66
C	HIS71
C	PHE83
C	PHE219
C	VAL222
C	ARG226
C	LYS236
C	HIS237
C	VAL238
C	GLY239

site_id	AE2
Number of Residues	13
Details	binding site for residue 3PE C 302

Chain	Residue
A	TRP331
A	GLN344
A	3PE607
B	ARG234
C	VAL91
C	PHE98
C	TRP99
C	PHE102
C	LYS103
C	TYR107
C	ASP117
D	ALA36
D	3PE101

site_id	AE3
Number of Residues	8
Details	binding site for residue LMU C 303

Chain	Residue
C	TYR186
C	ALA189
C	ALA190
C	GLY192
C	PHE193
C	PHE203
C	GLY207
C	PHE211

site_id	AE4
Number of Residues	13
Details	binding site for residue 3PE D 101

Chain	Residue
A	PHE328
A	VAL329
A	THR343
A	GLN344
A	TYR347
A	3PE607
C	TYR107
C	3PE302
D	LEU43
D	LEU46
D	ALA47
D	ASN50
D	ALA51

site_id	AE5
Number of Residues	5
Details	binding site for residue CU1 H 301

Chain	Residue
H	HIS217
H	CYS252
H	CYS256
H	MET263
H	CU1302

site_id	AE6
Number of Residues	5
Details	binding site for residue CU1 H 302

Chain	Residue
H	CYS252
H	GLU254
H	CYS256
H	HIS260
H	CU1301

site_id	AE7
Number of Residues	13
Details	binding site for residue 3PE I 301

Chain	Residue
I	TRP59
I	VAL62
I	SER66
I	HIS71
I	LEU79
I	PHE83
I	PHE219
I	ARG226
I	HIS231
I	LYS236
I	HIS237
I	VAL238
I	GLY239

site_id	AE8
Number of Residues	9
Details	binding site for residue 3PE I 302

Chain	Residue
G	TRP331
G	GLN344
H	ARG234
I	PHE98
I	TRP99
I	PHE102
I	LYS103
I	TYR107
J	3PE101

site_id	AE9
Number of Residues	2
Details	binding site for residue 3PE I 303

Chain	Residue
I	TRP245
J	PHE25

site_id	AF1
Number of Residues	11
Details	binding site for residue 3PE J 101

Chain	Residue
G	PHE281
G	VAL329
G	SER341
G	GLN344
G	TYR347
I	LEU106
I	TYR107
I	3PE302
J	ALA47
J	ASN50
J	ALA51

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiivlpafgivshviatfakkpifgylpmvyamvaigvlgfvvwa..HH

Chain	Residue	Details
A	TRP280-HIS334

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHswtvpafgvkqdavpgrlaqlwfraeregiffgq......CselCgisHayM

Chain	Residue	Details
B	VAL215-MET263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
B	PHE60-VAL80
A	PHE420-ILE440
A	LEU455-GLY475
A	LEU499-LEU519
G	ILE29-VAL49
G	VAL97-GLY117
G	LEU141-GLY161
G	LEU189-ILE209
G	LEU227-ALA247
G	ILE278-VAL298
G	ILE310-VAL330
B	TRP104-PHE124
G	PHE348-ALA368
G	MET381-LEU401
G	PHE420-ILE440
G	LEU455-GLY475
G	LEU499-LEU519
H	PHE60-VAL80
H	TRP104-PHE124
A	LEU227-ALA247
A	ILE278-VAL298
A	ILE310-VAL330
A	PHE348-ALA368
A	MET381-LEU401

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
B	HIS217
B	CYS252
B	CYS256
B	HIS260
H	HIS217
H	CYS252
H	CYS256
H	HIS260

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	HIS284
A	TYR288
A	HIS333
A	HIS334
G	HIS284
G	TYR288
G	HIS333
G	HIS334

site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000250

Chain	Residue	Details
A	HIS284
A	TYR288
G	HIS284
G	TYR288

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)