5WDQ

H-Ras mutant L120A bound to GMP-PNP at 100K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	34
Details	binding site for residue GNP A 201

Chain	Residue
A	GLY12
A	ASP30
A	GLU31
A	TYR32
A	PRO34
A	THR35
A	GLY60
A	GLN61
A	ASN116
A	LYS117
A	ASP119
A	GLY13
A	SER145
A	ALA146
A	LYS147
A	CA202
A	MG203
A	ACT206
A	HOH321
A	HOH340
A	HOH345
A	HOH389
A	VAL14
A	HOH390
A	HOH403
A	HOH411
A	HOH415
A	HOH425
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 202

Chain	Residue
A	SER17
A	THR35
A	GNP201
A	HOH321
A	HOH340

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 203

Chain	Residue
A	SER17
A	THR35
A	GNP201
A	HOH321
A	HOH340

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 204

Chain	Residue
A	PHE28
A	ASP30
A	GLU31
A	ASP33
A	HOH369
A	HOH426

---

site_id	AC5
Number of Residues	5
Details	binding site for residue NA A 205

Chain	Residue
A	LYS88
A	GLU91
A	ASP92
A	GLN95
A	HOH310

---

site_id	AC6
Number of Residues	8
Details	binding site for residue ACT A 206

Chain	Residue
A	ASN85
A	HIS94
A	ALA120
A	ALA121
A	GNP201
A	HOH314
A	HOH317
A	HOH383

---

site_id	AC7
Number of Residues	3
Details	binding site for residue ACT A 207

Chain	Residue
A	ARG149
A	GLU153
A	TYR157

---

site_id	AC8
Number of Residues	8
Details	binding site for residue MG A 208

Chain	Residue
A	GLY138
A	GLN165
A	HOH334
A	HOH393
A	HOH420
A	HOH441
A	HOH458
A	HOH458

---

site_id	AC9
Number of Residues	6
Details	binding site for residue MG A 209

Chain	Residue
A	ARG102
A	ARG102
A	ASP105
A	ASP105
A	HOH431
A	HOH431

---

site_id	AD1
Number of Residues	6
Details	binding site for residue MG A 210

Chain	Residue
A	HOH332
A	HOH332
A	HOH332
A	HOH335
A	HOH335
A	HOH335

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	17
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---