5WCH

Crystal structure of the catalytic domain of human USP9X

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0016579	biological_process	protein deubiquitination
C	0004843	molecular_function	cysteine-type deubiquitinase activity
C	0016579	biological_process	protein deubiquitination
D	0004843	molecular_function	cysteine-type deubiquitinase activity
D	0016579	biological_process	protein deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 2000

Chain	Residue
A	CYS1727
A	HIS1729
A	CYS1771
A	CYS1774

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 2000

Chain	Residue
B	CYS1727
B	HIS1729
B	CYS1771
B	CYS1774

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 2001

Chain	Residue
C	HIS1729
C	CYS1771
C	CYS1774
C	CYS1727

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN D 2000

Chain	Residue
D	CYS1727
D	HIS1729
D	CYS1771
D	CYS1774

---

Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknaGAtCYMNSvIQ

Chain	Residue	Details
A	GLY1558-GLN1573

---

site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YrLvGVlvHsGqasg..GHY

Chain	Residue	Details
A	TYR1863-TYR1880

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093, ECO:0000305|PubMed:30914461

Chain	Residue	Details
A	CYS1566
B	CYS1566
C	CYS1566
D	CYS1566

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093

Chain	Residue	Details
A	HIS1879
B	HIS1879
C	HIS1879
D	HIS1879

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:30914461, ECO:0007744|PDB:5WCH

Chain	Residue	Details
A	CYS1727
C	HIS1729
C	CYS1771
C	CYS1774
D	CYS1727
D	HIS1729
D	CYS1771
D	CYS1774
A	HIS1729
A	CYS1771
A	CYS1774
B	CYS1727
B	HIS1729
B	CYS1771
B	CYS1774
C	CYS1727

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1600
B	SER1600
C	SER1600
D	SER1600

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