5WCH
Crystal structure of the catalytic domain of human USP9X
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0016579 | biological_process | protein deubiquitination |
| B | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| B | 0016579 | biological_process | protein deubiquitination |
| C | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| C | 0016579 | biological_process | protein deubiquitination |
| D | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| D | 0016579 | biological_process | protein deubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 2000 |
| Chain | Residue |
| A | CYS1727 |
| A | HIS1729 |
| A | CYS1771 |
| A | CYS1774 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 2000 |
| Chain | Residue |
| B | CYS1727 |
| B | HIS1729 |
| B | CYS1771 |
| B | CYS1774 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 2001 |
| Chain | Residue |
| C | HIS1729 |
| C | CYS1771 |
| C | CYS1774 |
| C | CYS1727 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 2000 |
| Chain | Residue |
| D | CYS1727 |
| D | HIS1729 |
| D | CYS1771 |
| D | CYS1774 |
Functional Information from PROSITE/UniProt
| site_id | PS00972 |
| Number of Residues | 16 |
| Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknaGAtCYMNSvIQ |
| Chain | Residue | Details |
| A | GLY1558-GLN1573 |
| site_id | PS00973 |
| Number of Residues | 18 |
| Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YrLvGVlvHsGqasg..GHY |
| Chain | Residue | Details |
| A | TYR1863-TYR1880 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30914461","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30914461","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WCH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
