Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5WC0

katanin hexamer in spiral conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000212	biological_process	meiotic spindle organization
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000785	cellular_component	chromatin
A	0000922	cellular_component	spindle pole
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007019	biological_process	microtubule depolymerization
A	0007143	biological_process	female meiotic nuclear division
A	0008017	molecular_function	microtubule binding
A	0008352	cellular_component	katanin complex
A	0008568	molecular_function	microtubule severing ATPase activity
A	0009792	biological_process	embryo development ending in birth or egg hatching
A	0015630	cellular_component	microtubule cytoskeleton
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0019903	molecular_function	protein phosphatase binding
A	0042802	molecular_function	identical protein binding
A	0051013	biological_process	microtubule severing
A	0051229	biological_process	meiotic spindle disassembly
A	0051301	biological_process	cell division
A	0051321	biological_process	meiotic cell cycle
A	0060090	molecular_function	molecular adaptor activity
A	0071688	biological_process	striated muscle myosin thick filament assembly
A	0072687	cellular_component	meiotic spindle
A	0090619	cellular_component	meiotic spindle pole
A	0090736	molecular_function	MATH domain binding
A	1902120	biological_process	negative regulation of meiotic spindle elongation
B	0000212	biological_process	meiotic spindle organization
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000785	cellular_component	chromatin
B	0000922	cellular_component	spindle pole
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007019	biological_process	microtubule depolymerization
B	0007143	biological_process	female meiotic nuclear division
B	0008017	molecular_function	microtubule binding
B	0008352	cellular_component	katanin complex
B	0008568	molecular_function	microtubule severing ATPase activity
B	0009792	biological_process	embryo development ending in birth or egg hatching
B	0015630	cellular_component	microtubule cytoskeleton
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0019903	molecular_function	protein phosphatase binding
B	0042802	molecular_function	identical protein binding
B	0051013	biological_process	microtubule severing
B	0051229	biological_process	meiotic spindle disassembly
B	0051301	biological_process	cell division
B	0051321	biological_process	meiotic cell cycle
B	0060090	molecular_function	molecular adaptor activity
B	0071688	biological_process	striated muscle myosin thick filament assembly
B	0072687	cellular_component	meiotic spindle
B	0090619	cellular_component	meiotic spindle pole
B	0090736	molecular_function	MATH domain binding
B	1902120	biological_process	negative regulation of meiotic spindle elongation
C	0000212	biological_process	meiotic spindle organization
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000785	cellular_component	chromatin
C	0000922	cellular_component	spindle pole
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007019	biological_process	microtubule depolymerization
C	0007143	biological_process	female meiotic nuclear division
C	0008017	molecular_function	microtubule binding
C	0008352	cellular_component	katanin complex
C	0008568	molecular_function	microtubule severing ATPase activity
C	0009792	biological_process	embryo development ending in birth or egg hatching
C	0015630	cellular_component	microtubule cytoskeleton
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0019903	molecular_function	protein phosphatase binding
C	0042802	molecular_function	identical protein binding
C	0051013	biological_process	microtubule severing
C	0051229	biological_process	meiotic spindle disassembly
C	0051301	biological_process	cell division
C	0051321	biological_process	meiotic cell cycle
C	0060090	molecular_function	molecular adaptor activity
C	0071688	biological_process	striated muscle myosin thick filament assembly
C	0072687	cellular_component	meiotic spindle
C	0090619	cellular_component	meiotic spindle pole
C	0090736	molecular_function	MATH domain binding
C	1902120	biological_process	negative regulation of meiotic spindle elongation
D	0000212	biological_process	meiotic spindle organization
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000785	cellular_component	chromatin
D	0000922	cellular_component	spindle pole
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007019	biological_process	microtubule depolymerization
D	0007143	biological_process	female meiotic nuclear division
D	0008017	molecular_function	microtubule binding
D	0008352	cellular_component	katanin complex
D	0008568	molecular_function	microtubule severing ATPase activity
D	0009792	biological_process	embryo development ending in birth or egg hatching
D	0015630	cellular_component	microtubule cytoskeleton
D	0016853	molecular_function	isomerase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0019903	molecular_function	protein phosphatase binding
D	0042802	molecular_function	identical protein binding
D	0051013	biological_process	microtubule severing
D	0051229	biological_process	meiotic spindle disassembly
D	0051301	biological_process	cell division
D	0051321	biological_process	meiotic cell cycle
D	0060090	molecular_function	molecular adaptor activity
D	0071688	biological_process	striated muscle myosin thick filament assembly
D	0072687	cellular_component	meiotic spindle
D	0090619	cellular_component	meiotic spindle pole
D	0090736	molecular_function	MATH domain binding
D	1902120	biological_process	negative regulation of meiotic spindle elongation
E	0000212	biological_process	meiotic spindle organization
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000785	cellular_component	chromatin
E	0000922	cellular_component	spindle pole
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0007019	biological_process	microtubule depolymerization
E	0007143	biological_process	female meiotic nuclear division
E	0008017	molecular_function	microtubule binding
E	0008352	cellular_component	katanin complex
E	0008568	molecular_function	microtubule severing ATPase activity
E	0009792	biological_process	embryo development ending in birth or egg hatching
E	0015630	cellular_component	microtubule cytoskeleton
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0019903	molecular_function	protein phosphatase binding
E	0042802	molecular_function	identical protein binding
E	0051013	biological_process	microtubule severing
E	0051229	biological_process	meiotic spindle disassembly
E	0051301	biological_process	cell division
E	0051321	biological_process	meiotic cell cycle
E	0060090	molecular_function	molecular adaptor activity
E	0071688	biological_process	striated muscle myosin thick filament assembly
E	0072687	cellular_component	meiotic spindle
E	0090619	cellular_component	meiotic spindle pole
E	0090736	molecular_function	MATH domain binding
E	1902120	biological_process	negative regulation of meiotic spindle elongation
F	0000212	biological_process	meiotic spindle organization
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000785	cellular_component	chromatin
F	0000922	cellular_component	spindle pole
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007019	biological_process	microtubule depolymerization
F	0007143	biological_process	female meiotic nuclear division
F	0008017	molecular_function	microtubule binding
F	0008352	cellular_component	katanin complex
F	0008568	molecular_function	microtubule severing ATPase activity
F	0009792	biological_process	embryo development ending in birth or egg hatching
F	0015630	cellular_component	microtubule cytoskeleton
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0019903	molecular_function	protein phosphatase binding
F	0042802	molecular_function	identical protein binding
F	0051013	biological_process	microtubule severing
F	0051229	biological_process	meiotic spindle disassembly
F	0051301	biological_process	cell division
F	0051321	biological_process	meiotic cell cycle
F	0060090	molecular_function	molecular adaptor activity
F	0071688	biological_process	striated muscle myosin thick filament assembly
F	0072687	cellular_component	meiotic spindle
F	0090619	cellular_component	meiotic spindle pole
F	0090736	molecular_function	MATH domain binding
F	1902120	biological_process	negative regulation of meiotic spindle elongation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue ATP A 501

Chain	Residue
A	ILE195
A	LEU241
A	ASP292
A	LEU370
A	ALA399
B	ARG351
B	ARG352
A	ILE196
A	PRO234
A	PRO235
A	GLY236
A	THR237
A	GLY238
A	LYS239
A	THR240

site_id	AC2
Number of Residues	15
Details	binding site for residue ATP B 501

Chain	Residue
B	ILE195
B	ILE196
B	MET198
B	PRO234
B	PRO235
B	GLY236
B	THR237
B	GLY238
B	LYS239
B	THR240
B	LEU241
B	LEU370
B	ALA399
C	ARG351
C	ARG352

site_id	AC3
Number of Residues	14
Details	binding site for residue ATP C 501

Chain	Residue
C	ILE195
C	ILE196
C	PRO234
C	PRO235
C	GLY236
C	THR237
C	GLY238
C	LYS239
C	THR240
C	LEU241
C	LEU370
C	ALA399
D	ARG351
D	ARG352

site_id	AC4
Number of Residues	14
Details	binding site for residue ATP D 501

Chain	Residue
D	ILE195
D	ILE196
D	PRO235
D	GLY236
D	THR237
D	GLY238
D	LYS239
D	THR240
D	LEU241
D	LEU370
D	GLY398
D	ALA399
E	ARG351
E	ARG352

site_id	AC5
Number of Residues	14
Details	binding site for residue ATP E 501

Chain	Residue
E	ILE196
E	MET198
E	PRO235
E	GLY236
E	THR237
E	GLY238
E	LYS239
E	THR240
E	LEU241
E	ASP292
E	GLY398
E	ALA399
F	ARG351
F	ARG352

site_id	AC6
Number of Residues	12
Details	binding site for residue ATP F 501

Chain	Residue
F	ILE195
F	ILE196
F	PRO235
F	GLY236
F	THR237
F	GLY238
F	LYS239
F	THR240
F	LEU241
F	ASP292
F	GLY398
F	ALA399

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	20
Details	AAA AAA-protein family signature. VfVLaATNipweLDeALrrR

Chain	Residue	Details
A	VAL333-ARG352

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03023, ECO:0000269\|PubMed:28783150, ECO:0007744\|PDB:5WC0, ECO:0007744\|PDB:5WCB

Chain	Residue	Details
A	GLY233
B	GLY233
C	GLY233
D	GLY233
E	GLY233
F	GLY233

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:28783150, ECO:0007744\|PDB:5WC0, ECO:0007744\|PDB:5WCB

Chain	Residue	Details
A	ARG351
B	ARG351
C	ARG351
D	ARG351
E	ARG351
F	ARG351

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine; by mbk-2 => ECO:0000269\|PubMed:16338136

Chain	Residue	Details
A	SER92
B	SER92
C	SER92
D	SER92
E	SER92
F	SER92

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)