5W97
Crystal Structure of CO-bound Cytochrome c Oxidase determined by Serial Femtosecond X-Ray Crystallography at Room Temperature
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| a | 0004129 | molecular_function | cytochrome-c oxidase activity |
| a | 0005739 | cellular_component | mitochondrion |
| a | 0005743 | cellular_component | mitochondrial inner membrane |
| a | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| a | 0006119 | biological_process | oxidative phosphorylation |
| a | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| a | 0009060 | biological_process | aerobic respiration |
| a | 0015990 | biological_process | electron transport coupled proton transport |
| a | 0016020 | cellular_component | membrane |
| a | 0020037 | molecular_function | heme binding |
| a | 0045277 | cellular_component | respiratory chain complex IV |
| a | 0046872 | molecular_function | metal ion binding |
| a | 0070469 | cellular_component | respirasome |
| A | 0004129 | molecular_function | cytochrome-c oxidase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| A | 0006119 | biological_process | oxidative phosphorylation |
| A | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| A | 0009060 | biological_process | aerobic respiration |
| A | 0015990 | biological_process | electron transport coupled proton transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0045277 | cellular_component | respiratory chain complex IV |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070469 | cellular_component | respirasome |
| b | 0004129 | molecular_function | cytochrome-c oxidase activity |
| b | 0005507 | molecular_function | copper ion binding |
| b | 0005739 | cellular_component | mitochondrion |
| b | 0005743 | cellular_component | mitochondrial inner membrane |
| b | 0016020 | cellular_component | membrane |
| b | 0016491 | molecular_function | oxidoreductase activity |
| b | 0022900 | biological_process | electron transport chain |
| b | 0042773 | biological_process | ATP synthesis coupled electron transport |
| b | 0045277 | cellular_component | respiratory chain complex IV |
| b | 0046872 | molecular_function | metal ion binding |
| b | 0070469 | cellular_component | respirasome |
| b | 1902600 | biological_process | proton transmembrane transport |
| B | 0004129 | molecular_function | cytochrome-c oxidase activity |
| B | 0005507 | molecular_function | copper ion binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042773 | biological_process | ATP synthesis coupled electron transport |
| B | 0045277 | cellular_component | respiratory chain complex IV |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070469 | cellular_component | respirasome |
| B | 1902600 | biological_process | proton transmembrane transport |
| c | 0004129 | molecular_function | cytochrome-c oxidase activity |
| c | 0005739 | cellular_component | mitochondrion |
| c | 0005743 | cellular_component | mitochondrial inner membrane |
| c | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| c | 0008535 | biological_process | respiratory chain complex IV assembly |
| c | 0009055 | molecular_function | electron transfer activity |
| c | 0016020 | cellular_component | membrane |
| c | 0019646 | biological_process | aerobic electron transport chain |
| c | 0022904 | biological_process | respiratory electron transport chain |
| c | 0045277 | cellular_component | respiratory chain complex IV |
| c | 1902600 | biological_process | proton transmembrane transport |
| C | 0004129 | molecular_function | cytochrome-c oxidase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| C | 0008535 | biological_process | respiratory chain complex IV assembly |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016020 | cellular_component | membrane |
| C | 0019646 | biological_process | aerobic electron transport chain |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0045277 | cellular_component | respiratory chain complex IV |
| C | 1902600 | biological_process | proton transmembrane transport |
| d | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| d | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| D | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| D | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| e | 0005743 | cellular_component | mitochondrial inner membrane |
| e | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| e | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| E | 0005743 | cellular_component | mitochondrial inner membrane |
| E | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| E | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| f | 0005740 | cellular_component | mitochondrial envelope |
| f | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| f | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| F | 0005740 | cellular_component | mitochondrial envelope |
| F | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| F | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| g | 0005743 | cellular_component | mitochondrial inner membrane |
| g | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| G | 0005743 | cellular_component | mitochondrial inner membrane |
| G | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| h | 0005739 | cellular_component | mitochondrion |
| h | 0005743 | cellular_component | mitochondrial inner membrane |
| h | 0006119 | biological_process | oxidative phosphorylation |
| h | 0045277 | cellular_component | respiratory chain complex IV |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005743 | cellular_component | mitochondrial inner membrane |
| H | 0006119 | biological_process | oxidative phosphorylation |
| H | 0045277 | cellular_component | respiratory chain complex IV |
| i | 0005739 | cellular_component | mitochondrion |
| i | 0005743 | cellular_component | mitochondrial inner membrane |
| i | 0006119 | biological_process | oxidative phosphorylation |
| i | 0045277 | cellular_component | respiratory chain complex IV |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0005743 | cellular_component | mitochondrial inner membrane |
| I | 0006119 | biological_process | oxidative phosphorylation |
| I | 0045277 | cellular_component | respiratory chain complex IV |
| j | 0005746 | cellular_component | mitochondrial respirasome |
| j | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| j | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| J | 0005746 | cellular_component | mitochondrial respirasome |
| J | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| J | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| k | 0005746 | cellular_component | mitochondrial respirasome |
| k | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| K | 0005746 | cellular_component | mitochondrial respirasome |
| K | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| l | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| l | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| L | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| L | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| m | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| m | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| M | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| M | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue HEA A 601 |
| Chain | Residue |
| A | THR31 |
| A | VAL70 |
| A | GLY125 |
| A | TRP126 |
| A | TYR371 |
| A | PHE377 |
| A | HIS378 |
| A | SER382 |
| A | MET390 |
| A | MET417 |
| A | PHE425 |
| A | SER34 |
| A | GLN428 |
| A | ARG438 |
| A | ARG439 |
| A | VAL465 |
| A | MET468 |
| A | HOH724 |
| A | HOH726 |
| A | HOH747 |
| A | ILE37 |
| A | ARG38 |
| A | TYR54 |
| A | HIS61 |
| A | ALA62 |
| A | MET65 |
| A | ILE66 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | binding site for residue HEA A 602 |
| Chain | Residue |
| A | TRP126 |
| A | TRP236 |
| A | VAL243 |
| A | TYR244 |
| A | ILE247 |
| A | HIS290 |
| A | HIS291 |
| A | THR309 |
| A | ILE312 |
| A | GLY317 |
| A | GLY352 |
| A | GLY355 |
| A | LEU358 |
| A | ALA359 |
| A | ASP364 |
| A | HIS368 |
| A | VAL373 |
| A | HIS376 |
| A | PHE377 |
| A | VAL380 |
| A | ARG438 |
| A | CMO609 |
| A | HOH707 |
| A | HOH758 |
| A | HOH785 |
| A | HOH837 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CU A 603 |
| Chain | Residue |
| A | HIS240 |
| A | HIS290 |
| A | HIS291 |
| A | CMO609 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 604 |
| Chain | Residue |
| A | HIS368 |
| A | ASP369 |
| B | GLU198 |
| B | HOH419 |
| B | HOH421 |
| B | HOH486 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 605 |
| Chain | Residue |
| A | GLU40 |
| A | GLY45 |
| A | SER441 |
| A | HOH826 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue PGV A 606 |
| Chain | Residue |
| A | TRP409 |
| A | HOH701 |
| A | HOH765 |
| A | HOH790 |
| D | THR80 |
| M | GLN15 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue PGV A 607 |
| Chain | Residue |
| A | PHE94 |
| A | PRO95 |
| A | ARG96 |
| A | MET97 |
| A | HOH745 |
| C | HIS9 |
| C | ASN50 |
| C | MET54 |
| C | TRP57 |
| C | TRP58 |
| C | GLU64 |
| C | HIS71 |
| C | PHE86 |
| C | PEK302 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue TGL A 608 |
| Chain | Residue |
| A | VAL350 |
| A | ASN422 |
| A | PHE426 |
| A | PHE430 |
| A | LEU433 |
| B | GLY8 |
| B | LEU28 |
| I | ARG43 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue CMO A 609 |
| Chain | Residue |
| A | CU603 |
| A | HIS240 |
| A | VAL243 |
| A | HIS291 |
| A | HEA602 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CUA B 301 |
| Chain | Residue |
| B | HIS161 |
| B | CYS196 |
| B | GLU198 |
| B | CYS200 |
| B | HIS204 |
| B | MET207 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue PSC B 302 |
| Chain | Residue |
| B | HIS52 |
| B | ASP57 |
| B | GLU60 |
| B | HOH467 |
| E | ASP8 |
| E | LEU41 |
| I | ARG18 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue CHD B 303 |
| Chain | Residue |
| A | MET271 |
| B | GLN59 |
| B | GLU62 |
| B | THR63 |
| B | HOH414 |
| B | HOH442 |
| g | ARG14 |
| g | ARG17 |
| g | GLY22 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue CHD C 301 |
| Chain | Residue |
| A | ASP300 |
| A | THR301 |
| A | TYR304 |
| A | HOH845 |
| C | TRP99 |
| C | HIS103 |
| C | HOH453 |
| g | CDL103 |
| site_id | AD5 |
| Number of Residues | 14 |
| Details | binding site for residue PEK C 302 |
| Chain | Residue |
| A | PGV607 |
| C | TYR181 |
| C | TYR182 |
| C | ALA184 |
| C | PHE186 |
| C | THR187 |
| C | ILE188 |
| C | PHE198 |
| G | TRP62 |
| G | THR68 |
| G | PHE69 |
| G | PHE70 |
| G | HIS71 |
| G | ASN76 |
| site_id | AD6 |
| Number of Residues | 15 |
| Details | binding site for residue PGV C 303 |
| Chain | Residue |
| C | MET54 |
| C | VAL61 |
| C | SER65 |
| C | THR66 |
| C | ILE210 |
| C | ARG221 |
| C | HIS226 |
| C | HIS231 |
| C | HIS232 |
| C | PHE233 |
| C | GLY234 |
| C | CDL305 |
| C | HOH423 |
| C | HOH443 |
| F | HOH237 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue PGV C 304 |
| Chain | Residue |
| A | ASP298 |
| C | TYR102 |
| C | HIS103 |
| C | ALA107 |
| H | ASN22 |
| g | ALA1 |
| site_id | AD8 |
| Number of Residues | 12 |
| Details | binding site for residue CDL C 305 |
| Chain | Residue |
| C | MET54 |
| C | TYR55 |
| C | ARG63 |
| C | PHE67 |
| C | VAL217 |
| C | LYS224 |
| C | HIS226 |
| C | PGV303 |
| C | HOH414 |
| C | HOH446 |
| J | PHE12 |
| J | ASP28 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue CHD C 306 |
| Chain | Residue |
| C | ARG156 |
| C | PHE164 |
| J | PHE1 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue DMU C 307 |
| Chain | Residue |
| C | ASN38 |
| C | MET40 |
| C | HOH461 |
| G | TRP62 |
| G | GLY63 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue PEK C 308 |
| Chain | Residue |
| C | LYS157 |
| G | ARG17 |
| G | GLY22 |
| G | CDL101 |
| G | HOH242 |
| b | THR66 |
| b | CHD301 |
| site_id | AE3 |
| Number of Residues | 10 |
| Details | binding site for residue PEK C 309 |
| Chain | Residue |
| C | LYS77 |
| C | ARG80 |
| C | TYR81 |
| C | ILE84 |
| C | VAL91 |
| C | TRP240 |
| C | VAL247 |
| C | PHE251 |
| g | HIS8 |
| g | TPO11 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue TGL D 201 |
| Chain | Residue |
| A | TRP334 |
| A | LYS411 |
| D | TRP78 |
| D | HOH328 |
| I | ARG16 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 101 |
| Chain | Residue |
| F | CYS60 |
| F | CYS62 |
| F | CYS82 |
| F | CYS85 |
| site_id | AE6 |
| Number of Residues | 16 |
| Details | binding site for residue CDL G 101 |
| Chain | Residue |
| C | ASN125 |
| C | LEU127 |
| C | LEU131 |
| C | PEK308 |
| G | SER27 |
| G | CYS31 |
| G | ASN34 |
| G | LEU37 |
| G | HIS38 |
| G | HOH203 |
| a | PHE282 |
| a | ASP300 |
| a | TYR304 |
| a | SER307 |
| b | LEU78 |
| b | TYR85 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue PEK G 102 |
| Chain | Residue |
| G | ALA3 |
| G | TPO11 |
| G | HOH212 |
| c | ARG80 |
| c | GLU236 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue PGV G 103 |
| Chain | Residue |
| C | TRP258 |
| G | ALA1 |
| c | TRP99 |
| c | HIS103 |
| c | LEU106 |
| c | CHD302 |
| c | HOH439 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue CHD J 101 |
| Chain | Residue |
| J | ARG33 |
| J | THR37 |
| J | LEU40 |
| site_id | AF1 |
| Number of Residues | 10 |
| Details | binding site for residue TGL L 101 |
| Chain | Residue |
| A | LEU21 |
| A | TRP25 |
| A | PHE400 |
| A | ILE472 |
| L | ILE11 |
| L | PRO12 |
| L | PHE13 |
| L | ARG20 |
| L | MET25 |
| L | PHE29 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue DMU M 101 |
| Chain | Residue |
| A | PHE459 |
| D | TRP98 |
| M | LEU28 |
| M | GLY31 |
| M | TRP32 |
| M | TYR35 |
| M | HIS36 |
| site_id | AF3 |
| Number of Residues | 22 |
| Details | binding site for residue HEA a 601 |
| Chain | Residue |
| a | MET28 |
| a | THR31 |
| a | SER34 |
| a | ARG38 |
| a | TYR54 |
| a | VAL58 |
| a | HIS61 |
| a | ALA62 |
| a | MET65 |
| a | VAL70 |
| a | GLY125 |
| a | TRP126 |
| a | TYR371 |
| a | PHE377 |
| a | HIS378 |
| a | PHE425 |
| a | GLN428 |
| a | ARG438 |
| a | ARG439 |
| a | VAL465 |
| a | HOH722 |
| a | HOH725 |
| site_id | AF4 |
| Number of Residues | 27 |
| Details | binding site for residue HEA a 602 |
| Chain | Residue |
| a | TRP126 |
| a | TRP236 |
| a | VAL243 |
| a | TYR244 |
| a | HIS290 |
| a | HIS291 |
| a | THR309 |
| a | ILE312 |
| a | THR316 |
| a | GLY317 |
| a | GLY352 |
| a | GLY355 |
| a | ILE356 |
| a | LEU358 |
| a | ALA359 |
| a | ASP364 |
| a | HIS368 |
| a | HIS376 |
| a | PHE377 |
| a | VAL380 |
| a | LEU381 |
| a | ARG438 |
| a | CMO608 |
| a | HOH721 |
| a | HOH748 |
| a | HOH780 |
| a | HOH788 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue CU a 603 |
| Chain | Residue |
| a | HIS240 |
| a | HIS290 |
| a | HIS291 |
| a | CMO608 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue MG a 604 |
| Chain | Residue |
| a | HIS368 |
| a | ASP369 |
| b | GLU198 |
| b | HOH429 |
| b | HOH435 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue NA a 605 |
| Chain | Residue |
| a | GLU40 |
| a | GLY45 |
| a | SER441 |
| a | ASP442 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue TGL a 606 |
| Chain | Residue |
| a | TRP334 |
| b | HOH461 |
| d | THR75 |
| d | TRP78 |
| d | VAL81 |
| site_id | AF9 |
| Number of Residues | 10 |
| Details | binding site for residue PGV a 607 |
| Chain | Residue |
| a | ASN406 |
| a | THR408 |
| a | TRP409 |
| a | HOH705 |
| d | ALA84 |
| k | PHE9 |
| k | HIS10 |
| m | ALA3 |
| m | LYS4 |
| m | GLN15 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue CMO a 608 |
| Chain | Residue |
| a | HIS240 |
| a | VAL243 |
| a | HEA602 |
| a | CU603 |
| site_id | AG2 |
| Number of Residues | 11 |
| Details | binding site for residue CHD b 301 |
| Chain | Residue |
| C | PEK308 |
| G | ARG14 |
| G | ARG17 |
| G | PHE18 |
| G | GLY22 |
| a | MET271 |
| b | GLN59 |
| b | GLU62 |
| b | THR63 |
| b | HOH431 |
| b | HOH440 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue CUA b 302 |
| Chain | Residue |
| b | HIS161 |
| b | CYS196 |
| b | GLU198 |
| b | CYS200 |
| b | HIS204 |
| b | MET207 |
| site_id | AG4 |
| Number of Residues | 14 |
| Details | binding site for residue PGV c 301 |
| Chain | Residue |
| a | PHE94 |
| a | PRO95 |
| a | ARG96 |
| a | MET97 |
| a | HOH709 |
| c | HIS9 |
| c | ASN50 |
| c | MET54 |
| c | TRP57 |
| c | TRP58 |
| c | GLU64 |
| c | HIS71 |
| c | PHE93 |
| g | PEK102 |
| site_id | AG5 |
| Number of Residues | 8 |
| Details | binding site for residue CHD c 302 |
| Chain | Residue |
| G | PGV103 |
| a | HIS233 |
| a | ASP300 |
| a | THR301 |
| a | TYR304 |
| c | TRP99 |
| c | HIS103 |
| c | HOH439 |
| site_id | AG6 |
| Number of Residues | 7 |
| Details | binding site for residue PEK c 303 |
| Chain | Residue |
| A | TRP275 |
| B | GLN59 |
| B | THR66 |
| c | HIS158 |
| c | GLN161 |
| g | ARG17 |
| g | CDL103 |
| site_id | AG7 |
| Number of Residues | 17 |
| Details | binding site for residue PGV c 304 |
| Chain | Residue |
| c | TRP58 |
| c | VAL61 |
| c | SER65 |
| c | THR66 |
| c | THR213 |
| c | PHE214 |
| c | ARG221 |
| c | HIS226 |
| c | PHE227 |
| c | THR228 |
| c | HIS231 |
| c | HIS232 |
| c | PHE233 |
| c | GLY234 |
| c | CDL305 |
| c | HOH432 |
| f | HOH201 |
| site_id | AG8 |
| Number of Residues | 12 |
| Details | binding site for residue CDL c 305 |
| Chain | Residue |
| c | TYR55 |
| c | ARG59 |
| c | ILE62 |
| c | ARG63 |
| c | PHE67 |
| c | VAL217 |
| c | PHE220 |
| c | LYS224 |
| c | HIS226 |
| c | PGV304 |
| j | LYS8 |
| j | THR27 |
| site_id | AG9 |
| Number of Residues | 3 |
| Details | binding site for residue CHD c 306 |
| Chain | Residue |
| c | ARG156 |
| c | PHE164 |
| j | PHE1 |
| site_id | AH1 |
| Number of Residues | 8 |
| Details | binding site for residue DMU m 401 |
| Chain | Residue |
| a | LEU35 |
| d | TRP98 |
| d | TYR102 |
| m | LEU27 |
| m | LEU28 |
| m | TRP32 |
| m | TYR35 |
| m | HIS36 |
| site_id | AH2 |
| Number of Residues | 5 |
| Details | binding site for residue PSC e 201 |
| Chain | Residue |
| b | HIS52 |
| b | VAL61 |
| e | HIS5 |
| e | GLU6 |
| e | ASP8 |
| site_id | AH3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN f 101 |
| Chain | Residue |
| f | CYS60 |
| f | CYS62 |
| f | CYS82 |
| f | CYS85 |
| site_id | AH4 |
| Number of Residues | 3 |
| Details | binding site for residue DMU c 307 |
| Chain | Residue |
| c | MET40 |
| g | GLY63 |
| g | HOH202 |
| site_id | AH5 |
| Number of Residues | 15 |
| Details | binding site for residue PEK g 102 |
| Chain | Residue |
| a | THR207 |
| c | TYR181 |
| c | TYR182 |
| c | ALA184 |
| c | PHE186 |
| c | THR187 |
| c | ILE188 |
| c | PHE198 |
| c | LEU206 |
| c | PGV301 |
| g | THR68 |
| g | PHE69 |
| g | PHE70 |
| g | HIS71 |
| g | ASN76 |
| site_id | AH6 |
| Number of Residues | 18 |
| Details | binding site for residue CDL g 103 |
| Chain | Residue |
| A | ASP300 |
| A | SER307 |
| A | ILE311 |
| B | LEU78 |
| B | LEU81 |
| C | CHD301 |
| c | LEU131 |
| c | PEK303 |
| g | ALA1 |
| g | SER27 |
| g | CYS31 |
| g | ASN34 |
| g | HIS38 |
| g | HOH201 |
| g | HOH208 |
| g | HOH210 |
| g | HOH214 |
| g | HOH215 |
| site_id | AH7 |
| Number of Residues | 5 |
| Details | binding site for residue TGL i 101 |
| Chain | Residue |
| a | ASN422 |
| a | LEU433 |
| b | LEU7 |
| b | LEU28 |
| i | ARG43 |
| site_id | AH8 |
| Number of Residues | 4 |
| Details | binding site for residue CHD j 101 |
| Chain | Residue |
| j | TYR32 |
| j | ARG33 |
| j | MET36 |
| j | THR37 |
| site_id | AH9 |
| Number of Residues | 8 |
| Details | binding site for residue TGL l 101 |
| Chain | Residue |
| a | PHE2 |
| a | LEU18 |
| a | PHE400 |
| l | ILE11 |
| l | PHE13 |
| l | MET24 |
| l | PHE28 |
| l | PHE29 |
| site_id | AI1 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide HIS a 240 and TYR a 244 |
| Chain | Residue |
| a | TRP236 |
| a | PHE238 |
| a | GLY239 |
| a | PRO241 |
| a | GLU242 |
| a | VAL243 |
| a | ILE245 |
| a | LEU246 |
| a | ILE247 |
| a | LEU248 |
| a | ILE280 |
| a | GLY284 |
| a | VAL287 |
| a | HIS290 |
| a | ILE312 |
| a | HEA602 |
| a | CU603 |
| a | CMO608 |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 56 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH |
| Chain | Residue | Details |
| A | TRP236-HIS291 |
| site_id | PS00078 |
| Number of Residues | 49 |
| Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM |
| Chain | Residue | Details |
| B | VAL159-MET207 |
| site_id | PS00848 |
| Number of Residues | 23 |
| Details | COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL |
| Chain | Residue | Details |
| F | VAL69-LEU91 |
| site_id | PS01329 |
| Number of Residues | 18 |
| Details | COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN |
| Chain | Residue | Details |
| G | ILE55-ASN72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 58 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | MET1-PRO15 | |
| a | SER262-GLY269 | |
| a | SER401-ASN406 | |
| a | LYS479-LYS514 | |
| C | PHE67-THR72 | |
| C | GLU153-ASP155 | |
| C | LYS224-HIS232 | |
| c | MET1-PRO15 | |
| c | PHE67-THR72 | |
| c | GLU153-ASP155 | |
| c | LYS224-HIS232 | |
| a | MET171-PRO182 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=I => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | TRP16-TRP34 | |
| c | TRP16-TRP34 | |
| F | LYS90 | |
| f | LYS37 | |
| f | LYS55 | |
| f | LYS90 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 74 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | PHE35-MET40 | |
| C | LEU106-GLU128 | |
| C | ALA184-ASP190 | |
| C | TYR257-SER261 | |
| c | PHE35-MET40 | |
| c | LEU106-GLU128 | |
| c | ALA184-ASP190 | |
| c | TYR257-SER261 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=II => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | THR41-THR66 | |
| c | THR41-THR66 | |
| d | LYS7 | |
| d | LYS38 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 64 |
| Details | TRANSMEM: Helical; Name=III => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | PRO73-SER105 | |
| b | CYS200 | |
| b | HIS204 | |
| b | MET207 | |
| c | PRO73-SER105 | |
| B | GLU198 | |
| B | CYS200 | |
| B | HIS204 | |
| B | MET207 | |
| b | HIS161 | |
| b | CYS196 | |
| b | GLU198 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=IV => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | VAL129-MET152 | |
| c | VAL129-MET152 | |
| A | VAL287-ASP298 | |
| a | VAL118-GLY140 | |
| a | ARG213-ASP227 | |
| a | VAL287-ASP298 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=V => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | ARG156-GLU183 | |
| c | ARG156-GLU183 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 64 |
| Details | TRANSMEM: Helical; Name=VI => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | GLY191-LEU223 | |
| c | GLY191-LEU223 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | PHE233-ILE256 | |
| c | PHE233-ILE256 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | TYR270-ILE286 | |
| a | TYR270-ILE286 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=VIII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | VAL299-LEU327 | |
| a | VAL299-LEU327 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 14 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | HIS328-SER335 | |
| a | HIS328-SER335 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=IX => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | PRO336-VAL357 | |
| a | PRO336-VAL357 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 48 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | LEU358-THR370 | |
| A | SER434-ALA446 | |
| a | LEU358-THR370 | |
| a | SER434-ALA446 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 58 |
| Details | TRANSMEM: Helical; Name=X => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | TYR371-PHE400 | |
| a | TYR371-PHE400 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Name=XI => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | ASP407-LEU433 | |
| a | ASP407-LEU433 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 62 |
| Details | TRANSMEM: Helical; Name=XII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | TYR447-SER478 | |
| a | TYR447-SER478 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27605664, ECO:0000305|PubMed:23537388 |
| Chain | Residue | Details |
| A | GLU40 | |
| A | GLY45 | |
| A | SER441 | |
| a | GLU40 | |
| a | GLY45 | |
| a | SER441 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 6 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
| Chain | Residue | Details |
| A | HIS61 | |
| A | HIS376 | |
| A | HIS378 | |
| a | HIS61 | |
| a | HIS376 | |
| a | HIS378 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
| Chain | Residue | Details |
| A | HIS240 | |
| a | ASP369 | |
| A | HIS290 | |
| A | HIS291 | |
| A | HIS368 | |
| A | ASP369 | |
| a | HIS240 | |
| a | HIS290 | |
| a | HIS291 | |
| a | HIS368 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | TYR244 | |
| a | TYR244 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: N-formylmethionine => ECO:0000269|PubMed:2165784 |
| Chain | Residue | Details |
| A | FME1 | |
| a | FME1 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:10338009 |
| Chain | Residue | Details |
| A | HIS240 | |
| A | TYR244 | |
| a | HIS240 | |
| a | TYR244 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 14 |
| Details | M-CSA 124 |
| Chain | Residue | Details |
| A | HIS61 | metal ligand |
| A | HIS290 | metal ligand |
| A | HIS291 | metal ligand, proton acceptor, proton donor |
| A | THR316 | proton acceptor, proton donor, proton relay |
| A | LYS319 | proton acceptor, proton donor, proton relay |
| A | ARG438 | proton acceptor, proton donor, proton relay |
| A | ASP91 | proton acceptor, proton donor, proton relay |
| A | TRP126 | proton acceptor, proton donor, proton relay |
| A | SER156 | proton acceptor, proton donor, proton relay |
| A | SER157 | proton acceptor, proton donor, proton relay |
| A | HIS240 | covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser |
| A | GLU242 | proton acceptor, proton donor, proton relay |
| A | TYR244 | covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor |
| A | SER255 | proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| Number of Residues | 14 |
| Details | M-CSA 124 |
| Chain | Residue | Details |
| a | HIS61 | metal ligand |
| a | HIS290 | metal ligand |
| a | HIS291 | metal ligand, proton acceptor, proton donor |
| a | THR316 | proton acceptor, proton donor, proton relay |
| a | LYS319 | proton acceptor, proton donor, proton relay |
| a | ARG438 | proton acceptor, proton donor, proton relay |
| a | ASP91 | proton acceptor, proton donor, proton relay |
| a | TRP126 | proton acceptor, proton donor, proton relay |
| a | SER156 | proton acceptor, proton donor, proton relay |
| a | SER157 | proton acceptor, proton donor, proton relay |
| a | HIS240 | covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser |
| a | GLU242 | proton acceptor, proton donor, proton relay |
| a | TYR244 | covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor |
| a | SER255 | proton acceptor, proton donor, proton relay |
