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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5W92

Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-30049

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MN A 201
ChainResidue
AHIS41
AASP108
AGLU119
AILE120
AKU0203
site_idAC2
Number of Residues5
Detailsbinding site for residue MN A 202
ChainResidue
AHOH304
AGLU80
AASP108
AKU0203
AHOH302
site_idAC3
Number of Residues15
Detailsbinding site for residue KU0 A 203
ChainResidue
ATYR24
ALYS34
AILE38
AHIS41
AGLU80
APHE105
ALEU106
AASP108
AGLU119
AILE120
ALYS134
ALYS137
AMN201
AMN202
AHOH304
site_idAC4
Number of Residues4
Detailsbinding site for residue 9HD A 204
ChainResidue
AMET12
APHE46
AILE78
AGLY81
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"evidences":[{"source":"PubMed","id":"22876177","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27510745","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22876177","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26976575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27510745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29215062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29691337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29941893","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30351002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31536340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36603507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36655124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38190441","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CGV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D2O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D8U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D9J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EGA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VP8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VPT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VPX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W3I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W44","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W9G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WE9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WEF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WEI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WF3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DCZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E3M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E4C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K0W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ML8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MPF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MY5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N68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ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22876177","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26976575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27510745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29215062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29691337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29941893","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30351002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31536340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36603507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36655124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38190441","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D2O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D8U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D9J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EGA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VPT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VPX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W3I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W44","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W9G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WE9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WEF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WEI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WF3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DCZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E3M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E4C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K0W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ML8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MPF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MY5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N68","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CTF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DAL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ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22876177","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27510745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29215062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29691337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29941893","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30351002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31536340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36603507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36655124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38190441","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AVG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AWM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D2O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D8U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D9J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EGA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VPT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VPX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W3I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W44","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W9G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WE9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WEF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WEI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WF3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DCZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E3M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E4C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K0W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LM4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ML8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MPF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MY5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N68","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7V04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CTF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DJV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T5V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T5W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T67","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8T94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VGZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: 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ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: 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ChainResidueDetails

243911

PDB entries from 2025-10-29

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