5W7T

STRUCTURE OF PHOSPHORYLATED WNK1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ANP A 501

Chain	Residue
A	GLY230
A	LYS375
A	HOH621
A	HOH671
A	SER231
A	PHE232
A	LYS233
A	VAL235
A	THR301
A	GLU302
A	MET304
A	PHE356

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site_id	AC2
Number of Residues	11
Details	binding site for residue ANP B 501

Chain	Residue
B	GLY230
B	SER231
B	PHE232
B	LYS233
B	VAL235
B	ALA248
B	THR301
B	GLU302
B	HOH624
B	HOH636
B	HOH712

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKcdNIFI

Chain	Residue	Details
A	ILE345-ILE357

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"10828064","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16083423","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9H4A3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24803536","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4Q2A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"12374799","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"12374799","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22544747","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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