5W2P

Crystal structure of Mycobacterium tuberculosis KasA in complex with 6U5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0019367	biological_process	fatty acid elongation, saturated fatty acid
A	0030497	biological_process	fatty acid elongation
A	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 6U5 A 501

Chain	Residue
A	GLY117
A	ILE347
A	6U5502
A	GLU120
A	GLU199
A	GLY200
A	PRO201
A	GLU203
A	PRO206
A	PHE239
A	HIS345

---

site_id	AC2
Number of Residues	9
Details	binding site for residue 6U5 A 502

Chain	Residue
A	GLY115
A	LEU116
A	ILE145
A	MET146
A	GLU199
A	LEU205
A	PRO206
A	ILE347
A	6U5501

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 503

Chain	Residue
A	ALA18
A	VAL19
A	GLU30
A	SER97

---

site_id	AC4
Number of Residues	5
Details	binding site for residue NA A 504

Chain	Residue
A	ASN309
A	ALA310
A	GLU354
A	ASN399
A	ASN400

---

site_id	AC5
Number of Residues	3
Details	binding site for residue IPA A 505

Chain	Residue
A	VAL278
A	ILE317
A	TYR391

---

site_id	AC6
Number of Residues	4
Details	binding site for residue IPA A 506

Chain	Residue
A	ARG79
A	LEU156
A	MET277
A	HOH659

---

site_id	AC7
Number of Residues	2
Details	binding site for residue IPA A 507

Chain	Residue
A	ASP28
A	HOH617

---

site_id	AC8
Number of Residues	6
Details	binding site for residue TCE A 508

Chain	Residue
A	TRP95
A	PRO101
A	GLU102
A	VAL103
A	GLN157
A	LEU158

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	404
Details	Domain: {"description":"Ketosynthase family 3 (KS3)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19604480","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24108128","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24479625","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19604480","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24108128","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Site: {"description":"Interacts with the inhibitor thiolactomycin","evidences":[{"source":"PubMed","id":"19604480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24108128","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---