5W1V

Structure of the HLA-E-VMAPRTLIL/GF4 TCR complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
G	0000139	cellular_component	Golgi membrane
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002237	biological_process	response to molecule of bacterial origin
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010977	biological_process	negative regulation of neuron projection development
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0016020	cellular_component	membrane
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031901	cellular_component	early endosome membrane
G	0031902	cellular_component	late endosome membrane
G	0031905	cellular_component	early endosome lumen
G	0032092	biological_process	positive regulation of protein binding
G	0033077	biological_process	T cell differentiation in thymus
G	0034756	biological_process	regulation of iron ion transport
G	0035580	cellular_component	specific granule lumen
G	0042026	biological_process	protein refolding
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0045646	biological_process	regulation of erythrocyte differentiation
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0055038	cellular_component	recycling endosome membrane
G	0060586	biological_process	multicellular organismal-level iron ion homeostasis
G	0070062	cellular_component	extracellular exosome
G	0071281	biological_process	cellular response to iron ion
G	0071283	biological_process	cellular response to iron(III) ion
G	0071316	biological_process	cellular response to nicotine
G	1900121	biological_process	negative regulation of receptor binding
G	1900122	biological_process	positive regulation of receptor binding
G	1904434	biological_process	positive regulation of ferrous iron binding
G	1904437	biological_process	positive regulation of transferrin receptor binding
G	1904724	cellular_component	tertiary granule lumen
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation
L	0000139	cellular_component	Golgi membrane
L	0001913	biological_process	T cell mediated cytotoxicity
L	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
L	0002237	biological_process	response to molecule of bacterial origin
L	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
L	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
L	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
L	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
L	0002726	biological_process	positive regulation of T cell cytokine production
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005765	cellular_component	lysosomal membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005788	cellular_component	endoplasmic reticulum lumen
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005925	cellular_component	focal adhesion
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0007608	biological_process	sensory perception of smell
L	0007611	biological_process	learning or memory
L	0009897	cellular_component	external side of plasma membrane
L	0009986	cellular_component	cell surface
L	0010977	biological_process	negative regulation of neuron projection development
L	0012507	cellular_component	ER to Golgi transport vesicle membrane
L	0016020	cellular_component	membrane
L	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
L	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
L	0023026	molecular_function	MHC class II protein complex binding
L	0030670	cellular_component	phagocytic vesicle membrane
L	0031901	cellular_component	early endosome membrane
L	0031902	cellular_component	late endosome membrane
L	0031905	cellular_component	early endosome lumen
L	0032092	biological_process	positive regulation of protein binding
L	0033077	biological_process	T cell differentiation in thymus
L	0034756	biological_process	regulation of iron ion transport
L	0035580	cellular_component	specific granule lumen
L	0042026	biological_process	protein refolding
L	0042605	molecular_function	peptide antigen binding
L	0042612	cellular_component	MHC class I protein complex
L	0042613	cellular_component	MHC class II protein complex
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0042824	cellular_component	MHC class I peptide loading complex
L	0045646	biological_process	regulation of erythrocyte differentiation
L	0048260	biological_process	positive regulation of receptor-mediated endocytosis
L	0050680	biological_process	negative regulation of epithelial cell proliferation
L	0050768	biological_process	negative regulation of neurogenesis
L	0050778	biological_process	positive regulation of immune response
L	0050870	biological_process	positive regulation of T cell activation
L	0051289	biological_process	protein homotetramerization
L	0055038	cellular_component	recycling endosome membrane
L	0060586	biological_process	multicellular organismal-level iron ion homeostasis
L	0070062	cellular_component	extracellular exosome
L	0071281	biological_process	cellular response to iron ion
L	0071283	biological_process	cellular response to iron(III) ion
L	0071316	biological_process	cellular response to nicotine
L	1900121	biological_process	negative regulation of receptor binding
L	1900122	biological_process	positive regulation of receptor binding
L	1904434	biological_process	positive regulation of ferrous iron binding
L	1904437	biological_process	positive regulation of transferrin receptor binding
L	1904724	cellular_component	tertiary granule lumen
L	1990000	biological_process	amyloid fibril formation
L	1990712	cellular_component	HFE-transferrin receptor complex
L	2000774	biological_process	positive regulation of cellular senescence
L	2000978	biological_process	negative regulation of forebrain neuron differentiation
Q	0000139	cellular_component	Golgi membrane
Q	0001913	biological_process	T cell mediated cytotoxicity
Q	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
Q	0002237	biological_process	response to molecule of bacterial origin
Q	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
Q	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
Q	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
Q	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
Q	0002726	biological_process	positive regulation of T cell cytokine production
Q	0005198	molecular_function	structural molecule activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005765	cellular_component	lysosomal membrane
Q	0005783	cellular_component	endoplasmic reticulum
Q	0005788	cellular_component	endoplasmic reticulum lumen
Q	0005794	cellular_component	Golgi apparatus
Q	0005829	cellular_component	cytosol
Q	0005886	cellular_component	plasma membrane
Q	0005925	cellular_component	focal adhesion
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0006955	biological_process	immune response
Q	0007608	biological_process	sensory perception of smell
Q	0007611	biological_process	learning or memory
Q	0009897	cellular_component	external side of plasma membrane
Q	0009986	cellular_component	cell surface
Q	0010977	biological_process	negative regulation of neuron projection development
Q	0012507	cellular_component	ER to Golgi transport vesicle membrane
Q	0016020	cellular_component	membrane
Q	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
Q	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
Q	0023026	molecular_function	MHC class II protein complex binding
Q	0030670	cellular_component	phagocytic vesicle membrane
Q	0031901	cellular_component	early endosome membrane
Q	0031902	cellular_component	late endosome membrane
Q	0031905	cellular_component	early endosome lumen
Q	0032092	biological_process	positive regulation of protein binding
Q	0033077	biological_process	T cell differentiation in thymus
Q	0034756	biological_process	regulation of iron ion transport
Q	0035580	cellular_component	specific granule lumen
Q	0042026	biological_process	protein refolding
Q	0042605	molecular_function	peptide antigen binding
Q	0042612	cellular_component	MHC class I protein complex
Q	0042613	cellular_component	MHC class II protein complex
Q	0042802	molecular_function	identical protein binding
Q	0042803	molecular_function	protein homodimerization activity
Q	0042824	cellular_component	MHC class I peptide loading complex
Q	0045646	biological_process	regulation of erythrocyte differentiation
Q	0048260	biological_process	positive regulation of receptor-mediated endocytosis
Q	0050680	biological_process	negative regulation of epithelial cell proliferation
Q	0050768	biological_process	negative regulation of neurogenesis
Q	0050778	biological_process	positive regulation of immune response
Q	0050870	biological_process	positive regulation of T cell activation
Q	0051289	biological_process	protein homotetramerization
Q	0055038	cellular_component	recycling endosome membrane
Q	0060586	biological_process	multicellular organismal-level iron ion homeostasis
Q	0070062	cellular_component	extracellular exosome
Q	0071281	biological_process	cellular response to iron ion
Q	0071283	biological_process	cellular response to iron(III) ion
Q	0071316	biological_process	cellular response to nicotine
Q	1900121	biological_process	negative regulation of receptor binding
Q	1900122	biological_process	positive regulation of receptor binding
Q	1904434	biological_process	positive regulation of ferrous iron binding
Q	1904437	biological_process	positive regulation of transferrin receptor binding
Q	1904724	cellular_component	tertiary granule lumen
Q	1990000	biological_process	amyloid fibril formation
Q	1990712	cellular_component	HFE-transferrin receptor complex
Q	2000774	biological_process	positive regulation of cellular senescence
Q	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:30087334, ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P4B

Chain	Residue	Details
A	TYR7
F	TYR7
K	TYR7
P	TYR7

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P49, ECO:0007744|PDB:7P4B

Chain	Residue	Details
K	GLU63
P	GLU63
A	GLU63
F	GLU63

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:35705051, ECO:0007744|PDB:7P4B

Chain	Residue	Details
A	SER66
F	SER66
K	SER66
P	SER66
B	LYS91
B	LYS94
G	LYS19
G	LYS41
G	LYS48
G	LYS58
G	LYS91
G	LYS94
L	LYS19
L	LYS41
L	LYS48
L	LYS58
L	LYS91
L	LYS94
Q	LYS19
Q	LYS41
Q	LYS48
Q	LYS58
Q	LYS91
Q	LYS94

---

site_id	SWS_FT_FI4
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269|PubMed:18339401

Chain	Residue	Details
A	ASN77
A	TYR84
A	SER143
A	LYS146
A	GLN156
A	TYR159
A	TYR171
F	ASN77
F	TYR84
F	SER143
F	LYS146
F	GLN156
F	TYR159
F	TYR171
K	ASN77
K	TYR84
K	SER143
K	LYS146
K	GLN156
K	TYR159
K	TYR171
P	ASN77
P	TYR84
P	SER143
P	LYS146
P	GLN156
P	TYR159
P	TYR171

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN86
F	ASN86
K	ASN86
P	ASN86

---