5W1L
Echinococcus granulosus thioredoxin glutathione reductas (egTGR) with Gold
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue FAD A 601 |
| Chain | Residue |
| A | ILE115 |
| A | CYS156 |
| A | GLY160 |
| A | CYS161 |
| A | LYS164 |
| A | LEU227 |
| A | GLY228 |
| A | ALA256 |
| A | THR257 |
| A | GLY258 |
| A | TYR296 |
| A | GLY116 |
| A | ARG393 |
| A | ILE400 |
| A | GLY431 |
| A | ASP432 |
| A | GLN439 |
| A | LEU440 |
| A | THR441 |
| A | PRO442 |
| B | HIS570 |
| B | PRO571 |
| A | GLY118 |
| A | SER119 |
| A | GLY120 |
| A | ASP139 |
| A | PHE140 |
| A | GLY154 |
| A | THR155 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue AU A 602 |
| Chain | Residue |
| A | PHE504 |
| A | PRO506 |
| A | CYS519 |
| A | PRO541 |
| A | CYS573 |
| site_id | AC3 |
| Number of Residues | 31 |
| Details | binding site for residue FAD B 601 |
| Chain | Residue |
| A | HIS570 |
| B | ILE115 |
| B | GLY116 |
| B | GLY118 |
| B | SER119 |
| B | GLY120 |
| B | LEU138 |
| B | ASP139 |
| B | PHE140 |
| B | VAL141 |
| B | GLY154 |
| B | THR155 |
| B | CYS156 |
| B | GLY160 |
| B | CYS161 |
| B | LYS164 |
| B | ALA226 |
| B | LEU227 |
| B | GLY228 |
| B | ALA256 |
| B | THR257 |
| B | GLY258 |
| B | TYR296 |
| B | ARG393 |
| B | ILE400 |
| B | GLY431 |
| B | ASP432 |
| B | GLN439 |
| B | LEU440 |
| B | THR441 |
| B | PRO442 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue AU B 602 |
| Chain | Residue |
| B | PHE504 |
| B | PRO506 |
| B | CYS519 |
| B | PRO541 |
| B | CYS573 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
| Chain | Residue | Details |
| A | GLY153-PRO163 | |
| B | GLY153-PRO163 |
