5W1B
Tryptophan indole-lyase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006568 | biological_process | tryptophan metabolic process |
| A | 0006569 | biological_process | tryptophan catabolic process |
| A | 0009034 | molecular_function | tryptophanase activity |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016830 | molecular_function | carbon-carbon lyase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006568 | biological_process | tryptophan metabolic process |
| B | 0006569 | biological_process | tryptophan catabolic process |
| B | 0009034 | molecular_function | tryptophanase activity |
| B | 0009072 | biological_process | aromatic amino acid metabolic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016830 | molecular_function | carbon-carbon lyase activity |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006568 | biological_process | tryptophan metabolic process |
| C | 0006569 | biological_process | tryptophan catabolic process |
| C | 0009034 | molecular_function | tryptophanase activity |
| C | 0009072 | biological_process | aromatic amino acid metabolic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016830 | molecular_function | carbon-carbon lyase activity |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006568 | biological_process | tryptophan metabolic process |
| D | 0006569 | biological_process | tryptophan catabolic process |
| D | 0009034 | molecular_function | tryptophanase activity |
| D | 0009072 | biological_process | aromatic amino acid metabolic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016830 | molecular_function | carbon-carbon lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue K A 501 |
| Chain | Residue |
| A | GLY53 |
| A | ASN271 |
| A | HOH645 |
| A | HOH649 |
| B | GLU70 |
| B | HOH595 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue K A 502 |
| Chain | Residue |
| B | GLY53 |
| B | ASN271 |
| B | HOH647 |
| A | GLU70 |
| A | HOH640 |
| A | HOH695 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue K C 501 |
| Chain | Residue |
| C | GLU70 |
| C | HOH640 |
| C | HOH728 |
| D | GLY53 |
| D | ASN271 |
| D | HOH571 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue K C 502 |
| Chain | Residue |
| C | GLY53 |
| C | ASN271 |
| C | HOH683 |
| D | GLU70 |
| D | HOH586 |
Functional Information from PROSITE/UniProt
| site_id | PS00853 |
| Number of Residues | 19 |
| Details | BETA_ELIM_LYASE Beta-eliminating lyases pyridoxal-phosphate attachment site. YaDaltMSAKKDpLLnIGG |
| Chain | Residue | Details |
| A | TYR256-GLY274 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| A | LLP266 | |
| B | LLP266 | |
| C | LLP266 | |
| D | LLP266 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 410 |
| Chain | Residue | Details |
| A | TYR72 | proton shuttle (general acid/base) |
| A | PHE132 | steric role |
| A | ASP133 | electrostatic stabiliser, proton shuttle (general acid/base) |
| A | ASP223 | electrostatic stabiliser |
| A | ALA225 | steric role |
| A | LLP266 | covalent catalysis, proton shuttle (general acid/base) |
| A | HIS458 | activator, electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 410 |
| Chain | Residue | Details |
| B | TYR72 | proton shuttle (general acid/base) |
| B | PHE132 | steric role |
| B | ASP133 | electrostatic stabiliser, proton shuttle (general acid/base) |
| B | ASP223 | electrostatic stabiliser |
| B | ALA225 | steric role |
| B | LLP266 | covalent catalysis, proton shuttle (general acid/base) |
| B | HIS458 | activator, electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 7 |
| Details | M-CSA 410 |
| Chain | Residue | Details |
| C | TYR72 | proton shuttle (general acid/base) |
| C | PHE132 | steric role |
| C | ASP133 | electrostatic stabiliser, proton shuttle (general acid/base) |
| C | ASP223 | electrostatic stabiliser |
| C | ALA225 | steric role |
| C | LLP266 | covalent catalysis, proton shuttle (general acid/base) |
| C | HIS458 | activator, electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 7 |
| Details | M-CSA 410 |
| Chain | Residue | Details |
| D | TYR72 | proton shuttle (general acid/base) |
| D | PHE132 | steric role |
| D | ASP133 | electrostatic stabiliser, proton shuttle (general acid/base) |
| D | ASP223 | electrostatic stabiliser |
| D | ALA225 | steric role |
| D | LLP266 | covalent catalysis, proton shuttle (general acid/base) |
| D | HIS458 | activator, electrostatic stabiliser |
