5W1A

The first X-ray crystal structure of an insect muscle myosin. Drosophila melanogaster, skeletal muscle myosin II, an embryonic isoform, subfragment-1

Replaces:  4QBD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003774	molecular_function	cytoskeletal motor activity
A	0005524	molecular_function	ATP binding
A	0016459	cellular_component	myosin complex
A	0051015	molecular_function	actin filament binding
B	0005509	molecular_function	calcium ion binding
B	0005829	cellular_component	cytosol
B	0005859	cellular_component	muscle myosin complex
B	0006936	biological_process	muscle contraction
B	0007498	biological_process	mesoderm development
B	0016459	cellular_component	myosin complex
B	0030234	molecular_function	enzyme regulator activity
B	0032036	molecular_function	myosin heavy chain binding
B	0050790	biological_process	regulation of catalytic activity
C	0003774	molecular_function	cytoskeletal motor activity
C	0005524	molecular_function	ATP binding
C	0016459	cellular_component	myosin complex
C	0051015	molecular_function	actin filament binding
D	0005509	molecular_function	calcium ion binding
D	0005829	cellular_component	cytosol
D	0005859	cellular_component	muscle myosin complex
D	0006936	biological_process	muscle contraction
D	0007498	biological_process	mesoderm development
D	0016459	cellular_component	myosin complex
D	0030234	molecular_function	enzyme regulator activity
D	0032036	molecular_function	myosin heavy chain binding
D	0050790	biological_process	regulation of catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue FLC A 2000

Chain	Residue
A	SER181
A	HOH2188
A	GLY182
A	ALA183
A	GLY184
A	LYS185
A	THR186
A	GLU187
A	LYS680
A	HOH2119

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 2001

Chain	Residue
A	LEU267
A	LYS269
A	ALA651
A	HOH2161
A	HOH2324
A	HOH2372

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 2002

Chain	Residue
A	GLN486
A	PHE487
A	HIS490
A	ARG664
A	HOH2143
A	HOH2147
A	HOH2174

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 2003

Chain	Residue
A	VAL80
A	ASN81
A	HIS104
A	HOH2370

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 2004

Chain	Residue
A	LYS483
A	GLN486
A	ILE520
A	ARG664
A	HOH2146

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 2005

Chain	Residue
A	TYR500
A	ASP506
A	PHE509
A	PHE710

---

site_id	AC7
Number of Residues	9
Details	binding site for residue FLC C 2000

Chain	Residue
C	GLY182
C	GLY184
C	LYS185
C	THR186
C	GLU187
C	ASN239
C	HOH2102
C	HOH2167
C	HOH2376

---

site_id	AC8
Number of Residues	9
Details	binding site for residue GOL C 2001

Chain	Residue
C	SER241
C	ARG242
C	PHE243
C	GLY244
C	LEU266
C	ILE461
C	ALA462
C	TYR652
C	HOH2121

---

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL C 2002

Chain	Residue
C	TYR135
C	ASN137
C	ALA140
C	PHE156
C	THR198
C	HOH2141

---

site_id	AD1
Number of Residues	1
Details	binding site for residue EDO C 2003

Chain	Residue
C	ARG138

---

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LQHALLALGES

Chain	Residue	Details
B	LEU105-SER115

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	Domain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Region: {"description":"Actin-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00782","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	29
Details	Domain: {"description":"IQ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00116","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	68
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---