5W0I
CREBBP Bromodomain in complex with Cpd8 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 9UA A 1201 |
| Chain | Residue |
| A | PRO1106 |
| A | PHE1177 |
| A | SER1179 |
| A | GLU1186 |
| A | HOH1313 |
| A | HOH1391 |
| A | HOH1407 |
| A | HOH1411 |
| A | HOH1417 |
| A | LEU1109 |
| A | PRO1110 |
| A | VAL1115 |
| A | LEU1120 |
| A | ILE1122 |
| A | ASN1168 |
| A | ARG1173 |
| A | VAL1174 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 1202 |
| Chain | Residue |
| A | TYR1102 |
| A | ARG1112 |
| A | GLN1113 |
| A | HOH1310 |
| A | HOH1321 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 1203 |
| Chain | Residue |
| A | ARG1169 |
| A | LYS1170 |
| A | HOH1309 |
| A | HOH1328 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1204 |
| Chain | Residue |
| A | LEU1109 |
| A | ARG1112 |
| A | TRP1151 |
| A | HOH1303 |
| A | HOH1308 |
| A | HOH1310 |
| A | HOH1324 |
| A | HOH1340 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY |
| Chain | Residue | Details |
| A | SER1108-TYR1167 | |
