5W0E

CREBBP bromodomain in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 9U4 A 1201

Chain	Residue
A	PRO1106
A	PHE1177
A	GLU1186
A	HOH1304
A	HOH1326
A	HOH1381
A	LEU1109
A	PRO1110
A	PHE1111
A	VAL1115
A	ILE1122
A	ASN1168
A	ARG1173
A	VAL1174

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY

Chain	Residue	Details
A	SER1108-TYR1167

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	46
Details	Region: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Region: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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