5VWU
Crystal structure of oxidized Aspergillus fumigatus UDP-galactopyranose mutase complexed with NADH
Replaces: 4GDDFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0008767 | molecular_function | UDP-galactopyranose mutase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0071555 | biological_process | cell wall organization |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0008767 | molecular_function | UDP-galactopyranose mutase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0071555 | biological_process | cell wall organization |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0008767 | molecular_function | UDP-galactopyranose mutase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0071555 | biological_process | cell wall organization |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0008767 | molecular_function | UDP-galactopyranose mutase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | binding site for residue FAD A 601 |
| Chain | Residue |
| A | GLY14 |
| A | GLY61 |
| A | GLY62 |
| A | HIS63 |
| A | GLY240 |
| A | VAL242 |
| A | MET269 |
| A | THR295 |
| A | ARG327 |
| A | GLU373 |
| A | GLY418 |
| A | GLY16 |
| A | TYR419 |
| A | GLY446 |
| A | ARG447 |
| A | GLY456 |
| A | ASN457 |
| A | GLN458 |
| A | SER461 |
| A | NAI602 |
| A | HOH702 |
| A | PRO17 |
| A | THR18 |
| A | ASP38 |
| A | SER39 |
| A | GLY45 |
| A | LEU46 |
| A | ALA47 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue NAI A 602 |
| Chain | Residue |
| A | ILE65 |
| A | HIS68 |
| A | ARG91 |
| A | SER93 |
| A | TYR317 |
| A | ARG327 |
| A | TYR419 |
| A | ARG447 |
| A | TYR453 |
| A | ASN457 |
| A | HIS460 |
| A | FAD601 |
| A | SO4604 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | THR88 |
| A | HIS89 |
| A | GLN90 |
| A | LYS313 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | TYR317 |
| A | ARG327 |
| A | NAI602 |
| site_id | AC5 |
| Number of Residues | 28 |
| Details | binding site for residue FAD B 601 |
| Chain | Residue |
| B | GLY14 |
| B | GLY16 |
| B | PRO17 |
| B | THR18 |
| B | ASP38 |
| B | SER39 |
| B | GLY45 |
| B | LEU46 |
| B | ALA47 |
| B | GLY61 |
| B | GLY62 |
| B | HIS63 |
| B | GLY240 |
| B | VAL242 |
| B | MET269 |
| B | THR295 |
| B | ARG327 |
| B | GLU373 |
| B | GLY418 |
| B | TYR419 |
| B | GLY446 |
| B | ARG447 |
| B | GLY456 |
| B | ASN457 |
| B | GLN458 |
| B | SER461 |
| B | NAI602 |
| B | HOH703 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue NAI B 602 |
| Chain | Residue |
| B | ILE65 |
| B | HIS68 |
| B | ARG91 |
| B | SER93 |
| B | TYR104 |
| B | TYR317 |
| B | TYR419 |
| B | ARG447 |
| B | TYR453 |
| B | ASN457 |
| B | HIS460 |
| B | FAD601 |
| B | SO4605 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| B | LYS70 |
| B | ARG496 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| B | HIS89 |
| B | GLN90 |
| B | LYS313 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 605 |
| Chain | Residue |
| B | TRP315 |
| B | TYR317 |
| B | ARG327 |
| B | NAI602 |
| site_id | AD1 |
| Number of Residues | 26 |
| Details | binding site for residue FAD C 601 |
| Chain | Residue |
| C | GLY16 |
| C | PRO17 |
| C | THR18 |
| C | ASP38 |
| C | SER39 |
| C | GLY45 |
| C | LEU46 |
| C | ALA47 |
| C | VAL60 |
| C | GLY61 |
| C | GLY62 |
| C | HIS63 |
| C | GLY240 |
| C | VAL242 |
| C | THR268 |
| C | MET269 |
| C | HIS417 |
| C | GLY418 |
| C | GLY446 |
| C | ARG447 |
| C | GLY456 |
| C | ASN457 |
| C | GLN458 |
| C | SER461 |
| C | SO4605 |
| C | GLY14 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 602 |
| Chain | Residue |
| C | PRO307 |
| C | GLU308 |
| C | ARG309 |
| C | LYS402 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 603 |
| Chain | Residue |
| C | PRO114 |
| C | LYS115 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 604 |
| Chain | Residue |
| C | HIS89 |
| C | GLN90 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 605 |
| Chain | Residue |
| C | HIS63 |
| C | TYR419 |
| C | ARG447 |
| C | TYR453 |
| C | ASN457 |
| C | FAD601 |
| site_id | AD6 |
| Number of Residues | 26 |
| Details | binding site for residue FAD D 601 |
| Chain | Residue |
| D | GLY14 |
| D | GLY16 |
| D | PRO17 |
| D | THR18 |
| D | ASP38 |
| D | SER39 |
| D | GLY45 |
| D | LEU46 |
| D | ALA47 |
| D | VAL60 |
| D | GLY61 |
| D | GLY62 |
| D | HIS63 |
| D | GLY240 |
| D | VAL242 |
| D | THR268 |
| D | MET269 |
| D | HIS417 |
| D | GLY418 |
| D | GLY446 |
| D | ARG447 |
| D | GLY456 |
| D | ASN457 |
| D | GLN458 |
| D | SER461 |
| D | SO4605 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 602 |
| Chain | Residue |
| D | THR137 |
| D | LYS138 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 603 |
| Chain | Residue |
| D | PRO307 |
| D | GLU308 |
| D | ARG309 |
| D | LYS402 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 D 604 |
| Chain | Residue |
| D | LYS115 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 605 |
| Chain | Residue |
| D | HIS63 |
| D | TYR419 |
| D | ARG447 |
| D | TYR453 |
| D | ASN457 |
| D | FAD601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22294687, ECO:0000269|PubMed:22334662, ECO:0007744|PDB:3UKA, ECO:0007744|PDB:3UKH, ECO:0007744|PDB:3UKK, ECO:0007744|PDB:3UKL, ECO:0007744|PDB:3UKP, ECO:0007744|PDB:3UTE |
| Chain | Residue | Details |
| A | THR18 | |
| B | ASP38 | |
| B | LEU46 | |
| B | HIS63 | |
| B | VAL242 | |
| B | GLY456 | |
| B | GLN458 | |
| B | SER461 | |
| C | THR18 | |
| C | ASP38 | |
| C | LEU46 | |
| A | ASP38 | |
| C | HIS63 | |
| C | VAL242 | |
| C | GLY456 | |
| C | GLN458 | |
| C | SER461 | |
| D | THR18 | |
| D | ASP38 | |
| D | LEU46 | |
| D | HIS63 | |
| D | VAL242 | |
| A | LEU46 | |
| D | GLY456 | |
| D | GLN458 | |
| D | SER461 | |
| A | HIS63 | |
| A | VAL242 | |
| A | GLY456 | |
| A | GLN458 | |
| A | SER461 | |
| B | THR18 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22334662, ECO:0007744|PDB:3UKP |
| Chain | Residue | Details |
| A | GLY61 | |
| B | GLY61 | |
| C | GLY61 | |
| D | GLY61 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22334662, ECO:0007744|PDB:3UKF, ECO:0007744|PDB:3UKP, ECO:0007744|PDB:3UKQ |
| Chain | Residue | Details |
| A | GLY62 | |
| B | GLY62 | |
| C | GLY62 | |
| D | GLY62 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23036087, ECO:0007744|PDB:5VWT |
| Chain | Residue | Details |
| A | HIS68 | |
| B | SER93 | |
| B | ASN203 | |
| B | TRP315 | |
| B | ARG447 | |
| B | HIS460 | |
| C | HIS68 | |
| C | ARG91 | |
| C | SER93 | |
| C | ASN203 | |
| C | TRP315 | |
| A | ARG91 | |
| C | ARG447 | |
| C | HIS460 | |
| D | HIS68 | |
| D | ARG91 | |
| D | SER93 | |
| D | ASN203 | |
| D | TRP315 | |
| D | ARG447 | |
| D | HIS460 | |
| A | SER93 | |
| A | ASN203 | |
| A | TRP315 | |
| A | ARG447 | |
| A | HIS460 | |
| B | HIS68 | |
| B | ARG91 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22294687, ECO:0000269|PubMed:22334662, ECO:0007744|PDB:3UKF, ECO:0007744|PDB:3UKH, ECO:0007744|PDB:3UKP, ECO:0007744|PDB:3UKQ, ECO:0007744|PDB:3UTH |
| Chain | Residue | Details |
| A | TYR104 | |
| B | GLN107 | |
| B | ASN163 | |
| B | TRP167 | |
| B | ARG182 | |
| B | ASN207 | |
| B | TYR419 | |
| B | TYR453 | |
| C | TYR104 | |
| C | GLN107 | |
| C | ASN163 | |
| A | GLN107 | |
| C | TRP167 | |
| C | ARG182 | |
| C | ASN207 | |
| C | TYR419 | |
| C | TYR453 | |
| D | TYR104 | |
| D | GLN107 | |
| D | ASN163 | |
| D | TRP167 | |
| D | ARG182 | |
| A | ASN163 | |
| D | ASN207 | |
| D | TYR419 | |
| D | TYR453 | |
| A | TRP167 | |
| A | ARG182 | |
| A | ASN207 | |
| A | TYR419 | |
| A | TYR453 | |
| B | TYR104 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22334662, ECO:0007744|PDB:3UKH, ECO:0007744|PDB:3UKP |
| Chain | Residue | Details |
| A | MET159 | |
| A | TYR162 | |
| B | MET159 | |
| B | TYR162 | |
| C | MET159 | |
| C | TYR162 | |
| D | MET159 | |
| D | TYR162 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22294687, ECO:0000269|PubMed:22334662, ECO:0007744|PDB:3UKH, ECO:0007744|PDB:3UKQ, ECO:0007744|PDB:3UTH |
| Chain | Residue | Details |
| A | TYR317 | |
| B | TYR317 | |
| C | TYR317 | |
| D | TYR317 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22294687, ECO:0000269|PubMed:22334662, ECO:0007744|PDB:3UKF, ECO:0007744|PDB:3UKH, ECO:0007744|PDB:3UTH |
| Chain | Residue | Details |
| A | ARG327 | |
| B | ARG327 | |
| C | ARG327 | |
| D | ARG327 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22334662, ECO:0007744|PDB:3UKH |
| Chain | Residue | Details |
| A | ASN457 | |
| B | ASN457 | |
| C | ASN457 | |
| D | ASN457 |
