Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | TRP180 |
| A | GLU363 |
| A | PHE475 |
| A | TYR477 |
| A | H4B502 |
| A | 9PM503 |
| A | HOH609 |
| A | HOH627 |
| A | HOH628 |
| A | ALA183 |
| A | ARG185 |
| A | CYS186 |
| A | SER228 |
| A | PHE355 |
| A | SER356 |
| A | TRP358 |
| A | MET360 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue H4B A 502 |
| Chain | Residue |
| A | SER104 |
| A | VAL106 |
| A | ARG367 |
| A | ALA448 |
| A | TRP449 |
| A | HEM501 |
| A | GOL504 |
| A | HOH617 |
| A | HOH628 |
| B | TRP447 |
| B | PHE462 |
| B | HIS463 |
| B | GLN464 |
| B | GLU465 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue 9PM A 503 |
| Chain | Residue |
| A | VAL106 |
| A | LEU107 |
| A | VAL338 |
| A | TRP358 |
| A | GLU363 |
| A | TRP449 |
| A | TYR477 |
| A | HEM501 |
| A | GOL504 |
| B | TRP76 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ARG367 |
| A | HIS373 |
| A | H4B502 |
| A | 9PM503 |
| B | TRP76 |
| B | HIS463 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue HEM B 501 |
| Chain | Residue |
| B | TRP180 |
| B | ARG185 |
| B | CYS186 |
| B | SER228 |
| B | PHE355 |
| B | SER356 |
| B | TRP358 |
| B | MET360 |
| B | GLU363 |
| B | TRP449 |
| B | PHE475 |
| B | TYR477 |
| B | H4B502 |
| B | 9PM503 |
| B | HOH619 |
| B | HOH621 |
| B | HOH689 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue H4B B 502 |
| Chain | Residue |
| A | TRP447 |
| A | PHE462 |
| A | GLU465 |
| B | SER104 |
| B | ARG367 |
| B | ALA448 |
| B | TRP449 |
| B | HEM501 |
| B | GOL504 |
| B | HOH621 |
| B | HOH651 |
| B | HOH674 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue 9PM B 503 |
| Chain | Residue |
| A | TRP76 |
| B | LEU107 |
| B | PRO336 |
| B | VAL338 |
| B | PHE355 |
| B | TRP358 |
| B | GLU363 |
| B | TRP449 |
| B | TYR477 |
| B | HEM501 |
| B | GOL504 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | VAL106 |
| B | ARG367 |
| B | HIS373 |
| B | TRP449 |
| B | H4B502 |
| B | 9PM503 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 505 |
| Chain | Residue |
| A | CYS96 |
| A | CYS101 |
| B | CYS96 |
| B | CYS101 |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
| Chain | Residue | Details |
| A | ARG185-TRP192 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P35228","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by CDK5","evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
